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Synthesis and Conformation Analysis of δ-Amino Acid Related Peptides

Research Project

Project/Area Number 20550112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionOsaka Prefecture University

Principal Investigator

OKA Masahito  Osaka Prefecture University, 総合教育研究機構, 教授 (70203966)

Co-Investigator(Kenkyū-buntansha) HIRANO Yoshiaki  関西大学, 化学生命工学部, 教授 (80247874)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体関連高分子 / 高分子構造・物性 / 生体分子 / 理論化学
Research Abstract

From a new viewpoint recognizing peptide nucleic acid monomers are recognized as δ-amino acids, conformation study was carried out for the peptides ofδ -amino acids and of their related non-native amino-acids. It was shown that the most fundamental δ-amino acid residue have very interesting conformation properties caused by favorable intra-residue hydrogen bond, and also that theoretical results correspond to the experimental ones.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (26 results)

  • [Journal Article] Theoretical conformation analysis of 4-amino-4-S-methyl-2-butenoic acid residue and its peptides2011

    • Author(s)
      T. Kawaguchi, K. Inai, Y.Hirano, M.Oka
    • Journal Title

      Peptides Science 2010巻

      Pages: 155-155

    • NAID

      10028237656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural prediction of PNA double strands by ab initio calculations2011

    • Author(s)
      K. Inai, M.Oka
    • Journal Title

      Peptides Science 2010巻

      Pages: 157-157

    • NAID

      10028237662

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combination of RGDS and β-strand peptide for tissue engineering scaffold2011

    • Author(s)
      M. Wada, Y.Hirano
    • Journal Title

      Peptides Science 2010巻

      Pages: 271-271

    • NAID

      10028238146

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-peptides as a cross-linker for alginate hydrogel2011

    • Author(s)
      N. Nishimura, Y.Hirano
    • Journal Title

      Peptides Science 2010巻

      Pages: 274-274

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural prediction of PNA double strands by ab initio calculations2011

    • Author(s)
      K.Inai, M.Oka
    • Journal Title

      Peptide Science

      Volume: 2010(印刷中)

    • NAID

      10028237662

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical conformation analysis of 4-amino-4-s-methyl-2-butenoic acid residue and its peptides2011

    • Author(s)
      T.Kawaguchi, K.Inai, Y.Hirano, M.Oka
    • Journal Title

      Peptide Science

      Volume: 2010(印刷中)

    • NAID

      10028237656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of new type alginate hydrogel using self-assembly β-strand peptides2010

    • Author(s)
      Y.Hirano, N. Nishimura, H. Kimura
    • Journal Title

      Peptide Science 2009巻

      Pages: 399-402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical conformation analysis of peptides having double bond in main-chain2010

    • Author(s)
      T. Kawaguchi, Y.Hirano, M.Oka
    • Journal Title

      Peptides Science 2009巻

      Pages: 443-446

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 分岐型β-シートペプチドを用いた生体超分子の設計2010

    • Author(s)
      平野義明、田宮伸剛、岡勝仁
    • Journal Title

      高分子論文集 67巻

      Pages: 596-604

    • NAID

      10027448160

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical conformation analysis of peptides having double bonds in main-chain2010

    • Author(s)
      T.Kawaguchi, Y.Hirano, M.Oka
    • Journal Title

      Peptide Science 2009

      Pages: 443-446

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Built up of stimulus-responsive hydrogels using self-assembling・-hairpin peptides2009

    • Author(s)
      岡勝仁, 平野義明
    • Journal Title

      Peptide Science(N. Nishishita, Y. Morimoto) 2008巻

      Pages: 445-448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical design of new conjugated systems in main-chain2009

    • Author(s)
      T. Kawaguchi, Y.Hirano, M.Oka
    • Journal Title

      Peptides Science 2008巻

      Pages: 493-496

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular dynamic simulations of α-hairpin structures in aqueous solution system2009

    • Author(s)
      T. Kawaguchi, Y.Hirano, M.Oka
    • Journal Title

      Peptide Science 2008巻

      Pages: 497-500

    • NAID

      10027166768

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion behavior of human adipo-stromal cells on self-assembled monolayers with different surface densities or gradients of RGD peptide2009

    • Author(s)
      S. Inoue, Y. Iida, Y. Otani, Y. Tabata, Y.Hirano
    • Journal Title

      J.Biomater.Sci.Polym.Ed. 20巻

      Pages: 495-510

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion and proliferation of human adipo-stromal cells for two-or three-dimensional poly (ethylene terephthalate) substrates with or without RGD immobilization2009

    • Author(s)
      S. Inoue, M. Imamura, Y.Hirano, Y. Tabata
    • Journal Title

      J.Biomater.Sci.Polym.Ed. 20巻

      Pages: 721-736

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical Design of New Conjugated Systems in Main-Chain of Peptides2009

    • Author(s)
      T. Kawaguchi, Y. Hirano, M. Oka
    • Journal Title

      Pepetide Science 2008

      Pages: 493-496

    • NAID

      10027166766

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Structural prediction of PNA double strands by ab initio calculations2010

    • Author(s)
      K. Inai, M.Oka
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      Kyoto international conference center
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Theoretical conformation analysis of 4-amino-4-S-methyl-2-butenoic acid residue and its peptides2010

    • Author(s)
      川口拓也, K. Inai, Y.Hirano, M.Oka
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      Kyoto international conference center
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Combination of RGDS and β-strand peptide for tissue engineering scaffold2010

    • Author(s)
      M. Wada, Y.Hirano
    • Organizer
      5^<th> International Peptide Symposium
    • Place of Presentation
      Kyoto international conference center
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Structural prediction of PNA double strands by ab initio calculations2010

    • Author(s)
      K.Inai, M.Oka
    • Organizer
      5^<th> International Prptide symposium
    • Place of Presentation
      Kyoto international conference center
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Theoretical conformation analysis of 4-amino-4-s-methyl-2-butenoic acid residue and its peptides2010

    • Author(s)
      T.Kawaguchi, K.Inai, Y.Hirano, M.Oka
    • Organizer
      5^<th> International Prptide symposium
    • Place of Presentation
      Kyoto international conference center
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 量子化学計算による主鎖部分 に二重結合を有するペプチドの構造特性の解析2010

    • Author(s)
      岡勝仁
    • Organizer
      日本コンピュータ化学会2010秋季年会
    • Place of Presentation
      長岡技術科学大学
    • Year and Date
      2010-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 量子化学計算による主鎖部分に二重結合を有するペプチドの構造特性の解析2010

    • Author(s)
      岡勝仁
    • Organizer
      日本コンピュータ化学会2010秋季年会
    • Place of Presentation
      長岡技術科学大学
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 延伸構造が安定となるペプチドの理論的設計2010

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 自己組織化β-ヘアピンペプチドを用いたハイドロゲルの設計2010

    • Author(s)
      大田真平、平野義明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞接着配列とβ-シート構造を組み合わせたペプチドの機能評価2010

    • Author(s)
      和田全展、山本雅哉、田端泰彦、平野義明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] β-スとランドペプチドを架橋点に利用したアルギン酸ハイドロゲルの設計2010

    • Author(s)
      西村直剛、平野義明
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 4-アミノ-4-S-メチル-2-ブテン酸残基の構造特性の解析2010

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヘアピン基部にジスルフィド結合を有するα-ヘアピン構造の動的挙動2010

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第59回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 量子化学計算による主鎖共役性ペプチドの理論的設計2009

    • Author(s)
      岡勝仁
    • Organizer
      日本コンピュータ化学会2009秋季年会
    • Place of Presentation
      東北大学
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Theoretical design of new artificial polypeptides having conjugated characters2009

    • Author(s)
      川口拓也, 平野義明, 岡勝仁
    • Organizer
      1^<st> FAPS polymer congress
    • Place of Presentation
      Nagoya international conference center
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Conformation study of repetitive polypeptides having L-Pro-D-Pro sequence2009

    • Author(s)
      川口拓也, 平野義明, 岡勝仁
    • Organizer
      1^<st> FAPS polymer congress
    • Place of Presentation
      Nagoya international conference center
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Theoretical design of new artificial polypeptides having conjugated characters2009

    • Author(s)
      T.Kawaguchi, Y.Hirano, M.Oka
    • Organizer
      The 1^<st> FAPS Polymer Congress
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 4-アミノ-2-ブテン酸残基からなるペプチドのコンホメーション特性の理論的解析2009

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第58回高分子討論会
    • Place of Presentation
      熊本大学
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 理論化学による主鎖共役性ペプチドの分子設計2009

    • Author(s)
      岡勝仁
    • Organizer
      第24回生体機能関連化学シンポジウム
    • Place of Presentation
      九州大学
    • Year and Date
      2009-09-15
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヘリックスの中央部にジスルフィド結合を有するα0-ヘアピン構造の安定性2009

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第55回高分子研究発表会
    • Place of Presentation
      兵庫県民会館
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 4-アミノ-2-ブテン酸残基の構造特性の解析2009

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第58回高分子学会年次会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 二つのヘリックス間にジスルフィド結合を有するα-ヘアピン構造の動的挙動2009

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第58回高分子学会年次会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 量子化学計算による主鎖共役性ペプチドの理論的設計2008

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 主鎖に二重結合を有するアミノ酸残基の分子特性2008

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪市立大学
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] abinitio計算による3-アミノプロペン酸残基の構造特性の解析2008

    • Author(s)
      川口拓也、平野義明、岡勝仁
    • Organizer
      第54回高分子研究発表会
    • Place of Presentation
      兵庫県中央労働センター
    • Year and Date
      2008-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] ab initio計算による3-アミノプロペン酸残基の構造特性の解析2008

    • Author(s)
      川口拓也, 平野義明, 岡 勝仁
    • Organizer
      第54回高分子研究発表会
    • Place of Presentation
      兵庫県中央労働センター
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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