Functional difference between Notch ligands Dll1 and Dll3 in mouse somitogenesis
Project/Area Number |
20570215
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Developmental biology
|
Research Institution | National Institute of Health Sciences |
Principal Investigator |
TAKAHASHI Yu National Institute of Health Sciences, 毒性部, 室長 (60321858)
|
Co-Investigator(Renkei-kenkyūsha) |
KITAJIMA Satoshi 国立医薬品食品衛生研究所, 毒性部, 室長 (30270622)
YASUHIKO Yukuto 国立医薬品食品衛生研究所, 毒性部, 主任研究官 (40370944)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 体節形成 / Notchシグナル / マウス / 遺伝学 / 分子時計 / Delta |
Research Abstract |
We generated a Dll3-knockin mouse, which express Dll3 instead of Dll1, and analyzed effects on somitogenesis and molecular clock mechanism. Our results suggested that Dll3 is not a Notch ligand but acts as a suppressive modulator. In addition, these mice showed segmentation of vertebral body without Notch signal oscillation, implying presence of another mechanism.
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Report
(4 results)
Research Products
(17 results)
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[Book] 生物学辞典2010
Author(s)
石川統, 他編
Total Pages
1600
Publisher
東京化学同人
Related Report
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