| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Research Abstract |
Anti-conformational disease effects of naturally-occurring phenolic compounds and their glycosyl and lipophilic derivatives were investigated by using amyloidogenic proteins containing cystatin C L68Q variant and A β which are responsible for hereditary cystatin C amyloid angiopathy and Alzheimer's disease, respectively. As the result, it was revealed that lyophilization was more effective than glycosylation for improving anti-amyloidgenicity of the tested phenolic compounds. These observations regarding conformation-functional relationship can be useful for novel inhibitors' design as therapeutic agents for amyloid-associated diseases.
|
