Elucidation of a novel anti-allergic mechanism of pulverized dietary fiber and its application
| Project/Area Number |
20580134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAWAMOTO Seiji Hiroshima University, 大学院・先端物質科学研究科, 准教授 (90294537)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 微粉砕食物繊維 / グルコマンナン / アトピー性皮膚炎 / 機能性食品 / アレルギー性鼻炎 / 肥満細胞 / 免疫抑制作用 / NC / Ngaマウス / 自己免疫疾患 |
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| Research Abstract |
In the present study, I analyzed the mode of anti-allergic mechanism of pulverized dietary fiber, especially focused on konjac glucomannan (KGM) as a model diet. I found that dietary pulverized KGM (PKGM) had beneficial effect on the prevention of atopy-associated autoimmune response as well as on the suppression of nasal mast cell infiltration in the allergic rhinitis. I also found that PKGM supplementation induced T cell tolerance against excessive antigen-specific proliferative response. These results suggest that PKGM acts on multiple immune targets to fulfill its anti-inflammatory potency. I also determined optimal particle size of PKGM to achieve its anti-allergic effect, and generated a trial product of PKGM-supplemented food.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.2011
Author(s)
Kawamoto S., Kaneoke M., Ohkouchi K., Amano Y., Takaoka Y., Kume K., Aki T., Watanabe K., Kadowaki M., Hirata D., Ono K.
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Journal Title
Biosci. Biotechnol. Biochem. 75
Pages: 140-144
Related Report
Peer Reviewed
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[Journal Article] Immunological aspects and therapeutic significance of an auto-Ab against histone H1 in a rat model of Con A-induced hepatitis.2010
Author(s)
Nakano T., Goto S., Lai C.Y., Hsu L.W., Takaoka Y., Kawamoto S., Chiang K.C., Shimada Y., Ohmori N., Goto T., Sato S., Ono K., Cheng Y.F., Chen C.L.
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Journal Title
Immunology 129
Pages: 547-555
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and immunochemical characterization of a novel major Japanese cedar pollen allergen belonging to the aspartic protease family.2010
Author(s)
Ibrahim A.R.N., Kawamoto S., Aki T., Shimada Y., Rikimaru S., Onishi N., Babiker E.E., Oiso I., Hashimoto K., Hayashi T., Ono K.
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Journal Title
Int.Arch.Allergy Immunol. 152
Pages: 207-218
Related Report
Peer Reviewed
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