Study on molecular mechanisms by which sweet constituents of Siraitia grosvenori exert anti-diabetes and anti-arteriosclerosis effects

• Project/Area Number: 20580140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Osaka Prefecture University
• Principal Investigator: INUI Hiroshi Osaka Prefecture University, 生命環境科学研究科, 教授 (20193568)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ラカンカ / モグロシド / 抗糖尿病作用 / 動脈硬化予防作用 / インスリン膵臓β細胞 / 抗酸化作用 / 体内動態 / 非糖質系甘味料 / 動脈硬化症予防 / 消化・吸収 / アグリコン / インスリン / 膵臓β細胞 / 糖尿病 / 動脈硬化症

Research Abstract

Siraitia grosvenori, a traditional Chinese fruit used for a folk medicine, contains mogroside V, one of triterpene glycosides, and has been commercially available as a low-calorie sweetener for over-weight people and diabetic patients. In this study, the anti-diabetic effect of this fruit was examined, and it was found that mogrol, which is the aglycon of mogroside V, stimulated insulin secretion from pancreatic β-cells in vitro. From the aspect of anti-arteriosclerosis effect, it was elucidated that the extract of this fruit prevented oxidative stress induced by cholesterol loading in rats. In addition, the digestion, absorption, and disposition of mogroside V and its aglycon were also examined.

Research Products

• [Journal Article] Digestion and absorption of Siraitia grosvenori triterpenoids in the rat. (2010)
  • Author(s): Murata, Y., Ogawa, T., Suzuki, Y. A., Yoshikawa, S., Inui, H., Sugiura, M., Nakano, Y.
  • Journal Title: Biosci. Biotechnol. Biochem 74(有) Pages: 673-676
  • NAID: 10027553264
• [Journal Article] Digestion and absorption of Siraitia grosvenori triterpenoids in the rat (2010)
  • Author(s): Murata, et al.
  • Journal Title: Biosci.Biotechnol.Biochem. Volume: 73 Pages: 673-676
  • Peer Reviewed
• [Journal Article] Digestion and Absorption of Siraitia grosvenori Triterpenoids in the Rat (2010)
  • Author(s): Murata Y.Inui H, et al.
  • Journal Title: Biosci.Biotechnol. Biochem. 74(in press)
  • NAID: 10027553264
  • Peer Reviewed
• [Presentation] 羅漢果甘味配糖体の体内動態について (2010)
  • Author(s): 恒川直哉、竹内基世、小川貴央、鈴木靖志、吉川慎一、村田雄司、原田直樹、山地亮一、乾博
  • Organizer: 日本栄養・食糧学会第64回大会
  • Place of Presentation: (徳島)
  • Year and Date: 2010-05-23
• [Presentation] 羅漢果甘味配糖体の体内動態について (2010)
  • Author(s): 恒川直哉, 他
  • Organizer: 日本栄養・食糧学会第64回大会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-23
• [Presentation] 羅漢果甘味配糖体の抗糖尿病作用 (2008)
  • Author(s): 竹内基世、鈴木靖志、村田雄司、山地亮一、中野長久、乾博
  • Organizer: 日本栄養・食糧学会第47回近畿支部大会
  • Place of Presentation: 奈良
  • Year and Date: 2008-10-25
• [Presentation] 羅漢果甘味配糖体の抗糖尿病作用 (2008)
  • Author(s): 竹内基世, 乾博, 他
  • Organizer: 日本栄養・食糧学会近畿支部大会
  • Place of Presentation: 奈良女子大学
  • Year and Date: 2008-10-25