Antiparasitic components newly isolated from red algae for parasitic copepodes of cultured pufferfish

• Project/Area Number: 20580220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Fisheries chemistry
• Research Institution: Hiroshima University
• Principal Investigator: ASAKAWA Manabu Hiroshima University, 大学院・生物圏科学研究科, 准教授 (60243606)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: フグ / カイアシ類 / 寄生虫 / 興奮性アミノ酸 / 紅藻類 / カイニン酸 / 海人草 / ハナヤナギ / NMR / LC-MS / Copepoda / Pseudocaligus fugu / Takifugu rubripes / ドウモイ酸

Research Abstract

In aquaculture industry, caligid copepods are well known as pests causing heavy mortality or acting as disease inducers by creating a portal for entry of bacteria or other pathogens. The caligid Pseudocaligus fugu has been causing serious damages on cultured tiger puffer in western Japan. Hence we have tried to search for some antiparasitic agents which cause no damage on the host. Two compounds isolated from crude H_2O extract of "makuri", a red alga Digenea simplex showed effects on the parasite. One was kainic acid(C_<10>H_<15>NO_4, MW=213), and the other one showing the same molecular weight of it.

Research Products

• [Journal Article] Toxicity Assessment of the Xanthid Crab Demania cultripes from Cebu Island, Philippines, Journal of Toxicology (2010)
  • Author(s): Asakawa Manabu, Gomez-Delan Gloria, Tsuruda Shintaro, Shimomura Michitaka, Shida Yasuo, Taniyama Shigeto, Barte-Quilantang Mercy, Shindo Jo
  • Journal Title: Article ID 172367,電子投稿 Pages: 7-7
• [Journal Article] Toxicity Assessment of the Xanthid Crab Demania cultripes from Cebu Island, Philippines (2010)
  • Author(s): Manabu Asakawa
  • Journal Title: Journal of Toxicology Volume: 2010
  • Peer Reviewed
• [Journal Article] Developemental stages and growth of Pseudocaligus fugu Yamaguchi, 1936 (Copepods : Siphonostomatoida : Caligidae) host-specific to puffer (2009)
  • Author(s): Ohtsuka Susumu, Takami Ikuo, Venmathi Maran B.A., Ogawa kazoo, Shimono Takaki, Fujita Yusuke, Asakawa Manabu, Boxshall G.A.
  • Journal Title: Journal of Natural History 43 Pages: 1779-1804
  • Peer Reviewed
• [Journal Article] ハコフグ類の喫食による食中毒の実態と同魚類の毒性調査 (2009)
  • Author(s): 谷山茂人, 相良剛史, 西尾幸郎, 黒木亮一, 浅川学, 野口玉雄, 山崎脩平, 高谷智裕, 荒川修
  • Journal Title: 食品衛生学雑誌 50 Pages: 270-277
  • NAID: 130000135400
  • Peer Reviewed
• [Journal Article] 魚類の毒(3):コイ毒およびその他の毒 (2009)
  • Author(s): 浅川学
  • Journal Title: 食品衛生研究 59 Pages: 35-40
  • Peer Reviewed
• [Journal Article] 自然毒中毒(動物毒,植物毒) (2009)
  • Author(s): 中野宏幸, 浅川学
  • Journal Title: 生態影響と予防,臨床検査 53 Pages: 673-681
  • Peer Reviewed
• [Journal Article] Developemental stages and growth of Pseudocaligus fugu Yamaguchi, 1936 (Copepoda : Siphonostomatoida : Caligidae) host-specifis to Puffer (2009)
  • Author(s): Susumu Ohtsuka
  • Journal Title: Journal of Natural History 43 Pages: 1779-1804
  • Peer Reviewed
• [Journal Article] ハコフグ類の喫食による食中毒の実態と同魚類の毒性調査 (2009)
  • Author(s): 谷山茂人
  • Journal Title: 食品衛生学雑誌 50 Pages: 270-277
  • Peer Reviewed
• [Presentation] Toxicity of ribbon worm Cephalothrix species on the surface of the shell of cultured oysters in Hiroshima Bay,, Hiroshima prefecture, Japan (2011)
  • Author(s): Manabu Asakawa
  • Organizer: 50^<th> Anniversary Annual Meeting and ToxExpo
  • Place of Presentation: Washington, D.C., USA
  • Year and Date: 2011-03-09
• [Presentation] Toxicity of excitatory amino acids in red algae for parasitic copepods of cultured pufferfish (2011)
  • Author(s): 安井かおり, 浅川学
  • Organizer: 50^<th> Anniversary Annual Meeting and ToxExpo
  • Place of Presentation: Washington, D.C., USA.
  • Year and Date: 2011-03-08
• [Presentation] Toxicity of ribbon worm Cephalothrix species on the surface of the shell of cultured oysters in Hiroshima Bay, Hiroshima Prefecture, Japan (2011)
  • Author(s): 浅川学
  • Organizer: 50^<th> Anniversary Annual Meeting and ToxExpo
  • Place of Presentation: USA.
  • Year and Date: 2011-03-08
• [Presentation] Toxicity of excitatory amino acids in red algae for parasitic copepods of cultured pufferfish (2011)
  • Author(s): Manabu Asakawa
  • Organizer: 50^<th> Anniversary Annual Meeting and ToxExpo
  • Place of Presentation: Washington, D.C., USA
  • Year and Date: 2011-03-08
• [Presentation] 日本沿岸に生息する数種紐形動物の毒性 (2010)
  • Author(s): 安井かおり, 藤田雄介, 石本泰之, 金田拓磨, 日比野由衣, 志田保夫, 孫世春, 柁原宏, 浅川学
  • Organizer: 平成22年度日本水産学会秋季大会
  • Place of Presentation: 京都大学総合人間学部
  • Year and Date: 2010-09-24
• [Presentation] Occurrence of PSP-producing dinoflagellate Alexandrium tamiyavanichii in Bingo-Nada, the eastern coastal water of Hiroshima Prefecture, Japan (2008)
  • Author(s): 浅川 学
  • Organizer: 第5回世界水産学会議
  • Place of Presentation: パシフィコ横浜(横浜市)