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Antiparasitic components newly isolated from red algae for parasitic copepodes of cultured pufferfish

Research Project

Project/Area Number 20580220
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionHiroshima University

Principal Investigator

ASAKAWA Manabu  Hiroshima University, 大学院・生物圏科学研究科, 准教授 (60243606)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsフグ / カイアシ類 / 寄生虫 / 興奮性アミノ酸 / 紅藻類 / カイニン酸 / 海人草 / ハナヤナギ / NMR / LC-MS / Copepoda / Pseudocaligus fugu / Takifugu rubripes / ドウモイ酸
Research Abstract

In aquaculture industry, caligid copepods are well known as pests causing heavy mortality or acting as disease inducers by creating a portal for entry of bacteria or other pathogens. The caligid Pseudocaligus fugu has been causing serious damages on cultured tiger puffer in western Japan. Hence we have tried to search for some antiparasitic agents which cause no damage on the host. Two compounds isolated from crude H_2O extract of "makuri", a red alga Digenea simplex showed effects on the parasite. One was kainic acid(C_<10>H_<15>NO_4, MW=213), and the other one showing the same molecular weight of it.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Toxicity Assessment of the Xanthid Crab Demania cultripes from Cebu Island, Philippines, Journal of Toxicology2010

    • Author(s)
      Asakawa Manabu, Gomez-Delan Gloria, Tsuruda Shintaro, Shimomura Michitaka, Shida Yasuo, Taniyama Shigeto, Barte-Quilantang Mercy, Shindo Jo
    • Journal Title

      Article ID 172367,電子投稿

      Pages: 7-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Toxicity Assessment of the Xanthid Crab Demania cultripes from Cebu Island, Philippines2010

    • Author(s)
      Manabu Asakawa
    • Journal Title

      Journal of Toxicology

      Volume: 2010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developemental stages and growth of Pseudocaligus fugu Yamaguchi, 1936 (Copepods : Siphonostomatoida : Caligidae) host-specific to puffer2009

    • Author(s)
      Ohtsuka Susumu, Takami Ikuo, Venmathi Maran B.A., Ogawa kazoo, Shimono Takaki, Fujita Yusuke, Asakawa Manabu, Boxshall G.A.
    • Journal Title

      Journal of Natural History 43

      Pages: 1779-1804

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ハコフグ類の喫食による食中毒の実態と同魚類の毒性調査2009

    • Author(s)
      谷山茂人, 相良剛史, 西尾幸郎, 黒木亮一, 浅川学, 野口玉雄, 山崎脩平, 高谷智裕, 荒川修
    • Journal Title

      食品衛生学雑誌 50

      Pages: 270-277

    • NAID

      130000135400

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 魚類の毒(3):コイ毒およびその他の毒2009

    • Author(s)
      浅川学
    • Journal Title

      食品衛生研究 59

      Pages: 35-40

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自然毒中毒(動物毒,植物毒)2009

    • Author(s)
      中野宏幸, 浅川学
    • Journal Title

      生態影響と予防,臨床検査 53

      Pages: 673-681

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developemental stages and growth of Pseudocaligus fugu Yamaguchi, 1936 (Copepoda : Siphonostomatoida : Caligidae) host-specifis to Puffer2009

    • Author(s)
      Susumu Ohtsuka
    • Journal Title

      Journal of Natural History 43

      Pages: 1779-1804

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ハコフグ類の喫食による食中毒の実態と同魚類の毒性調査2009

    • Author(s)
      谷山茂人
    • Journal Title

      食品衛生学雑誌 50

      Pages: 270-277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Toxicity of ribbon worm Cephalothrix species on the surface of the shell of cultured oysters in Hiroshima Bay,, Hiroshima prefecture, Japan2011

    • Author(s)
      Manabu Asakawa
    • Organizer
      50^<th> Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2011-03-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Toxicity of excitatory amino acids in red algae for parasitic copepods of cultured pufferfish2011

    • Author(s)
      安井かおり, 浅川学
    • Organizer
      50^<th> Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA.
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Toxicity of ribbon worm Cephalothrix species on the surface of the shell of cultured oysters in Hiroshima Bay, Hiroshima Prefecture, Japan2011

    • Author(s)
      浅川学
    • Organizer
      50^<th> Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      USA.
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Toxicity of excitatory amino acids in red algae for parasitic copepods of cultured pufferfish2011

    • Author(s)
      Manabu Asakawa
    • Organizer
      50^<th> Anniversary Annual Meeting and ToxExpo
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本沿岸に生息する数種紐形動物の毒性2010

    • Author(s)
      安井かおり, 藤田雄介, 石本泰之, 金田拓磨, 日比野由衣, 志田保夫, 孫世春, 柁原宏, 浅川学
    • Organizer
      平成22年度日本水産学会秋季大会
    • Place of Presentation
      京都大学総合人間学部
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Occurrence of PSP-producing dinoflagellate Alexandrium tamiyavanichii in Bingo-Nada, the eastern coastal water of Hiroshima Prefecture, Japan2008

    • Author(s)
      浅川 学
    • Organizer
      第5回世界水産学会議
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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