Study of environmental pollution by pharmaceuticals and effect of environmental factors on the toxicity.
| Project/Area Number |
20590122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUGIHARA Kazumi Hiroshima University, 薬学部, 准教授 (20271067)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Shigeru 広島大学, 大学院・医歯薬学総合研究科, 教授 (60160503)
KITAMURA Shigeyuki 日本薬科大学, 薬学部, 教授 (40136057)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIJIMA Wataru 広島大学, 環境安全センター, 教授 (20243602)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 医薬品 / 環境汚染 / 太陽光 / 紫外線 / 生態毒性 / 環境因子 / 変異原性 |
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| Research Abstract |
In this study, we detected pharmaceuticals in Kurose river, a rural river located in Higashihiroshima city, Hiroshima, Japan. We observed their concentrations were higher than those of reported. Photodegradation of pharmaceuticals caused by sun irradiation may be of major elimination process in natural. In this study, we carried out the ultraviolet (UV) irradiation experiments for nine pharmaceuticals. The toxicity of pharmaceuticals was changed by UV irradiation.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells2009
Author(s)
Kojima, Hiroyuki, Takeuchi, Shinji, Uramaru, Naoto, Sugihara, Kazumi, Yoshida, Takahiko, Kitamura, Shigeyuki
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Journal Title
Environmental Health Perspectives 17(8)
Pages: 1210-1218
Related Report
Peer Reviewed
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[Journal Article] Disruption of thyroid hormone function by environmental Pollutants2009
Author(s)
Kashiwagi, Keiko, Furuno, Nobuaki, Kitamura, Shigeyuki, Ohta, Shigeru, Sugihara, Kazumi, Utsumi, Kozo, Hanada, Hideki, Taniguchi Kikuyo, Suzuki, Ken-ichi, Kashiwagi, Akihiko
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Journal Title
Journal of Health Science 55(2)
Pages: 147-160
NAID
Related Report
Peer Reviewed
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[Book] Endocrine Disruption in Toxic Responses. In Ballantyne Bryan(ed), the 3rd Edition of General and Applied Toxicology2009
Author(s)
Kitamura, Shigeyuki, Sugihara, Kazumi, Nakamura, Kazuo, Yaichiro Kotake, Kashiwagi, Akihiko, Fujimoto, Nariaki
Total Pages
15
Publisher
Johan Wiley and Sons Ltd
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