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Responses of neurotransmitter release in the brain to somatosensory stimulation, and its relation with emotion and autonomic responses

Research Project

Project/Area Number 20590216
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionInternational University of Health and Welfare

Principal Investigator

KUROSAWA Mieko  国際医療福祉大学, 薬学部, 教授 (30178131)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords触刺激 / 神経伝達物質 / ドーパミン / 側坐核 / セロトニン / 扁桃体 / 侵害性刺激 / コルチコトロピン放出因子 / 自律反応 / 腹側被蓋野 / 情動
Research Abstract

Tactile stimulation produces psychological effects such as relaxation, the alleviation of anxiety and depression, and the reduction of lassitude. That the psychological effects evoked by touch therapy involve stimulation of dopamine or serotonin release is suggested by their increased levels in the urine following tactile skin stimulation ; however, there is no direct evidence of their increased release in the brain. In the present study, we have shown that the tactile stimulation increases dopamine release in the nucleus accumbens, the nucleus known to play a key role for producing a pleasant feeling, whereas the same stimulation decreases serotonin release in the central nucleus of amygdala, the nucleus known to participate in the anxiety.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (29 results) Book (2 results)

  • [Journal Article] Tactile skin stimulation increases dopamine release in the nucleus accumbens in rats2012

    • Author(s)
      Maruyama K, Shimoju R, Ohkubo M, Maruyama H, Kurosawa M
    • Journal Title

      Journal of Physiological Sciences

      Volume: 62 Pages: 259-266

    • NAID

      10030742523

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚への触刺激による側坐核ドーパミン放出2012

    • Author(s)
      黒澤美枝子, 丸山貴美子, 下重里江
    • Journal Title

      自律神経

      Volume: 49(2) Pages: 92-94

    • NAID

      10030800177

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] Electro-acupuncture improves responsiveness to insulin via excitation of somatic afferent fibers in diabetic rats2009

    • Author(s)
      Higashimura Yukie
    • Journal Title

      Autonomic Neurosciences Basic & Clinical 150

      Pages: 100-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β3アドレナリン受容体作動薬投与時のラット血糖反応におよぼす骨格筋鍼通電刺激の影響2009

    • Author(s)
      三田裕一
    • Journal Title

      自律神経 46

      Pages: 327-332

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Responses of dorsal spinal cord blood flow to noxious mechanical stimulation of the skin in anesthetized rats2008

    • Author(s)
      Hiroko Toda
    • Journal Title

      Journal of Physiological Sciences 58

      Pages: 263-270

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympatho-adrenal medullary function in response to somatosensory stimulation2008

    • Author(s)
      Mieko Kurosawa
    • Journal Title

      Journal of the Japan Society of Neurovegetative Research 45

      Pages: 32-42

    • NAID

      10024485809

    • Related Report
      2008 Annual Research Report
  • [Presentation] 体性感覚刺激時の扁桃体中心核セロトニン放出反応におけるコルチコトロピン放出因子の関与2012

    • Author(s)
      徳永亮太, 下重里江, 大久保真人, 丸山仁司, 黒澤美枝子
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館,長野県/松本市
    • Year and Date
      2012-03-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 体性感覚刺激時の扁桃体中心核セロトニン放出反応におけるコルチコトロピン放出因子の関与2012

    • Author(s)
      徳永亮太
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館(松本市)
    • Year and Date
      2012-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 側坐核ドーパミン放出におよぼす皮膚触刺激の影響2011

    • Author(s)
      黒澤美枝子, 丸山貴美子, 徳永亮太, 下重里江
    • Organizer
      第22回マイクロダイアリシス研究
    • Place of Presentation
      お茶の水女子大学,東京/文京区
    • Year and Date
      2011-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 側坐核ドーパミン放出におよぼす皮膚触刺激の影響2011

    • Author(s)
      黒澤美枝子
    • Organizer
      第22回マイクロダイアリシス研究会
    • Place of Presentation
      お茶の水女子大学(文京区)
    • Year and Date
      2011-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 皮膚への触刺激による側坐核ドーパミン放出2011

    • Author(s)
      黒澤美枝子
    • Organizer
      第64回日本自律神経学会総会シンポジウム
    • Place of Presentation
      秋田ビューホテル,秋田県/秋田市
    • Year and Date
      2011-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 皮膚への触刺激による側坐核ドーパミン放出2011

    • Author(s)
      黒澤美枝子
    • Organizer
      第64回日本自律神経学会総会
    • Place of Presentation
      秋田ビューホテル(秋田市)
    • Year and Date
      2011-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット扁桃体セロトニン放出におよぼす皮膚触刺激の影響2011

    • Author(s)
      黒澤美枝子, 下重里江, 徳永亮太, 大久保真人
    • Organizer
      第1回国際医療福祉大学学会
    • Place of Presentation
      国際医療福祉大学,栃木県/大田原市
    • Year and Date
      2011-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット扁桃体セロトニン放出におよぼす皮膚触刺激の影響2011

    • Author(s)
      黒澤美枝子
    • Organizer
      国際医療福祉大学学会
    • Place of Presentation
      国際医療福祉大学(大田原市)
    • Year and Date
      2011-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体性感覚刺激によるラット扁桃体セロトニン放出の変化2011

    • Author(s)
      徳永亮太, 下重里江, 大久保真人, 黒澤美枝子
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2011-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 体性感覚刺激によるラット扁桃体セロトニン放出の変化2011

    • Author(s)
      徳永亮太
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      (東日本大震災のため)(誌上開催)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] タッチケアの自律神経系に及ぼす影響2010

    • Author(s)
      黒澤美枝子
    • Organizer
      第32回日本疼痛学会シンポジウム
    • Place of Presentation
      国立京都国際会館,京都府/京都市
    • Year and Date
      2010-07-03
    • Related Report
      2010 Final Research Report
  • [Presentation] タッチケアの自律神経系に及ぼす影響2010

    • Author(s)
      黒澤美枝子
    • Organizer
      第32回日本疼痛学会シンポジウム
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 皮膚への触刺激によるラット側坐核でのドーパミン放出増加反応2010

    • Author(s)
      黒澤美枝子, 丸山貴美子, 下重里江
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール,岩手県/盛岡市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 皮膚への触刺激によるラット側坐核でのドーパミン放出増加反応2010

    • Author(s)
      黒澤美枝子
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(盛岡市)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体性感覚刺激によるラットの側坐核ドーパミン放出反応2009

    • Author(s)
      黒澤美枝子, 丸山貴美子, 下重里江
    • Organizer
      第37回自律神経生理研究会
    • Place of Presentation
      日本光電工業本社研修センター,東京
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 骨格筋鍼通電刺激がI型糖尿病モデルラットの循環機能におよぼす影響 ―血糖値の高さによる反応の違いについて―2009

    • Author(s)
      東村幸枝
    • Organizer
      第62回日本自律神経学会総会
    • Place of Presentation
      ダイワロイヤルネット和歌山(和歌山市)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体性感覚刺激によるラットの側坐核ドーパミン放出反応2009

    • Author(s)
      黒澤美枝子
    • Organizer
      第37回自律神経生理研究会
    • Place of Presentation
      日本光電工業本社研修センター(東京都)
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cutaneous tactile stimulation increases dopamine release in the nucleus accumbens via excitation of the ventral tegmental area in rats2009

    • Author(s)
      Shimoju R, Maruyama K, Ohkubo M, Maruyama H, Kurosawa M
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場,名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Cutaneous tactile stimulation increases dopamine release in the nucleus accumbens via excitation of the ventral tegmental area in rats2009

    • Author(s)
      黒澤美枝子
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of cutaneous noxious mechanical stimulation on dorsal spinal cord blood flow in anesthetized rats2009

    • Author(s)
      黒澤美枝子
    • Organizer
      6th Congress of International Society for Autonomic Neuroscience
    • Place of Presentation
      Sydney Manly Pacific Hotel(Sydney, Australia)
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Circulatory responses to electro-acupuncture of the hindlimb in diabetic rats2009

    • Author(s)
      東村幸枝
    • Organizer
      36th International Congress for Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Responses of spinal cord blood flow to various types of somatosensory stimulation in anesthetized rats2009

    • Author(s)
      黒澤美枝子
    • Organizer
      36th International Congress for Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Electro-acupuncture modulates responsiveness of plasma glucose to beta3-adrenoceptor stimulation in rats2009

    • Author(s)
      Mita Yuichi
    • Organizer
      36th International Congress for Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tactile stimulation and dopamine release in the rat nucleus accumbens2009

    • Author(s)
      Shimoju R, Maruyama K, Kurosawa M
    • Organizer
      36th International Congress for Physiological Sciences
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2009-07-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Tactile stimulation and dopamine release in the rat nucleus accumbens2009

    • Author(s)
      Shimoju Rie
    • Organizer
      36th International Congress for Physiological Sciences
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脊髄血流におよぼす種々の体性感覚刺激の影響2008

    • Author(s)
      黒澤美枝子
    • Organizer
      第36回自律神経生理研究会
    • Place of Presentation
      日本光電本社研修センター
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨格筋刺激時のラット肝グルコース放出反応ーマイクロダイアリシス法を用いた検討2008

    • Author(s)
      下重里江
    • Organizer
      第19回マイクロダイアリシス研究会
    • Place of Presentation
      昭和女子大学研究館
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットの脊髄血流におよぼす後肢足蹠鍼通電刺激の影響-体性感覚神経の関与2008

    • Author(s)
      黒澤美枝子
    • Organizer
      第61回日本自律神経学会総会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラツト血糖におよぼすβ_3アドレナリン受容体作動薬の影響2008

    • Author(s)
      三田裕一
    • Organizer
      第61回日本自律神経学会総会
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Book] トートラ人体の構造と機能-泌尿器系, 第3版2010

    • Author(s)
      黒澤美枝子(分担訳)
    • Total Pages
      45
    • Publisher
      丸善出版
    • Related Report
      2009 Annual Research Report
  • [Book] ストレス百科事典-血圧2009

    • Author(s)
      黒澤美枝子(分担訳)
    • Total Pages
      5
    • Publisher
      丸善出版
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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