| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We previously reported that mutations in TGFB1 and TGFBR2 caused autosomal dominant disorders (Cammurati-Engelmann disease and Marfansyndrome type II). To reveal the relationship between unregulated production/adoption of extracellular matrix proteins andaberrant TGF signaling, I tried to establish model mice harboring mutant allelesofTgfb1orTgfbr2. However, all of chimera mice were infertile, and I could not accomplish this investigation program.
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