Analysis for carcinogenesis of lung cancer in idiopathic pulmonary fibrosis by inflammation and precancerous change

• Project/Area Number: 20590336
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: The University of Tokyo
• Principal Investigator: OTA Satoshi The University of Tokyo, 大学院・医学系研究科, 講師 (90324342)
• Co-Investigator(Kenkyū-buntansha): FUKAYAMA Masashi 東京大学, 大学院・医学系研究科, 教授 (70281293) ; ISHIKAWA Shunpei 東京大学, 大学院・医学系研究科, 准教授 (50418638)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺がん / 肺癌 / 炎症 / 前癌状態 / 特発性肺線維症

Research Abstract

Idiopathic pulmonary fibrosis is the interstitial pneumonia of unknown cause and refractory lesion, with a high risk for lung cancer. To study the difference of squamous cell carcinoma with or without idiopathic pulmonary fibrosis, the transcriptome expression level of each squamous cell carcinoma sample were compared. Famous oncogene MYCN, cytoskeleton protein MYH11, unknown function protein ARMC4 were upregulated. One of downregulated protein was MTSS-1 which supposed to be the role as disassembling the actin fibers.

Research Products

• [Journal Article] Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. (2010)
  • Author(s): Kusakabe M, Ota S, Fukayama M, Takai D., et.al.
  • Journal Title: International Journal of Cancer 126 Pages: 1895-1902
  • Peer Reviewed
• [Journal Article] AKR1B10 in usual interstitial pneumonia : expression in squamous metaplasia in association with smoking and lung cancer. (2008)
  • Author(s): Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M
  • Journal Title: Pathol.Res.Pract. 204(5) Pages: 295-304
  • Peer Reviewed