Studies of pathophysiological role of Adrenomedullin-RAMP system using genetically modified RAMP mice
| Project/Area Number |
20590395
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
SAKURAI Takayuki Shinshu University, 医学系研究科, 准教授 (80317825)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDO Takayuki 信州大学, 医学系研究科, 教授 (90345215)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アドレノメデュリン / 受容体修飾因子 / Receptor activity modifying protein (RAMP) / 血管作動性ペプチド / 心血管系 / 疾患モデル動物 / 発生工学 / Receptor activity modifying protein / 血管新生 / リンパ管形成 |
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| Research Abstract |
Adrenomedullin (AM) is a vasoactive peptide which is secreted by many tissues, and plays an important role in anti-inflammation, vasodilation and angiogenesis. AM receptor is composed of two proteins ; calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP) 2 or 3. The space- and time-dependent use of RAMPs became suggested to be important for unique AM function in several organs. However, the mechanisms and roles of RAMPs in the AM-RAMPs system remain obscure. In this study, we investigated the pathophysiological role of RAMP2/3 using vascular endothelial cell-specific and cardiac cell-specific RAMP2 KO mice because of the embryonic lethal of RAMP2KO at mid-gestation, and RAMP3KO including RAMP2/RAMP3 and RAMP3-Tg mice. We have found that (1) RAMP2 is essential for vascular and cardiac homeostasis based on the vaso- and organ-protective effects of AM (2) RAMP3 is involved in inflammatory response.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver2010
Author(s)
Iinuma, N, Sakurai, T, Kamiyoshi, A, Ichikawa-Shindo, Y, Arai, T, Yoshizawa, T, Koyama T, Uetake, R, Kawate, H, Muto, S, Tagawa, Y Miyagawa, S, Shindo, T
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Journal Title
PEPTIDES 31(5)
Pages: 865-871
NAID
Related Report
Peer Reviewed
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[Journal Article] Endogenous alpha-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin2009
Author(s)
Kamiyoshi,A, Sakurai,T, Ichikawa Y, Iinuma N Kawate, H, Yoshizawa T, Koyama T, Muto, S, Shindo,T
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Journal Title
A.Liver Int 29(5)
Pages: 642-649
Related Report
Peer Reviewed
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[Presentation] in development and senescence Teruhide Koyama2010
Author(s)
Takayuki Sakurai, Akiko Koyama, Takuma Arai, Yuka Shindo, Takahiro Yoshizawa, Takahiro Yoshizawa, Ryuichi Uetake, Yang Lei, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Takayuki Shindo
Organizer
Asian Aging Core for Longevity Research and Education 2010 Jeju Conference Regulation of vascular homeostasis by adrenomedullin-Ramp2 system
Place of Presentation
ジェジュ 韓国
Related Report
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[Presentation] as a Novel Regulator of Cardiac Homeostasis Takahiro Yoshizawa2010
Author(s)
Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate, Teruhide Koyama, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Takayuki Shindo
Organizer
The 14^<th> Scientific Session of the Society of Cardiovascular Endocrinology and Metabolism (CVEM) AM-RAMP2 System
Place of Presentation
NARA JAPAN
Related Report
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[Presentation] Determinant of the Vascular Functionsof Adrenomedullin2009
Author(s)
T Shindo, T Sakurai, A Kamiyoshi, Y Shindo, H Kawate, N Iinuma, T Arai, T Yoshizawa, T Koyama, N Shimoyama, R Uetake, A Yamauchi
Organizer
10th International Symposium on Mechanisms of Vasodilatation RANP2 is the Key
Place of Presentation
宮城
Year and Date
2009-06-01
Related Report
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[Presentation] RAMP2, a novel regulator of angiogenesis, vascular integrity, and homeostasis.2009
Author(s)
Shindo T, Koyama T, Sakurai T, Kamiyoshi A, Shindo Y, Iinuma N, Arai T, Yoshizawa T, Shimoyama N, Uetake R, Kawate H.
Organizer
第73回日本循環器学会学術集会総会
Place of Presentation
大阪
Year and Date
2009-03-21
Related Report
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