Imaging analysis of the brain in a primate model of cerebral malaria
| Project/Area Number |
20590427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
KAWAI Satoru Dokkyo Medical University, 医学部, 准教授 (70275733)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUTOMI Yasuhiro 独立行政法人医薬基盤研究所筑波霊長類医科学研究センター, センター長 (90281724)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MRI / 脳マラリア / Plasmodium coatneyi / マラリア疾患モデル / ニホンザル / 磁気共鳴画像 |
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| Research Abstract |
To elucidate the clinical features of cerebral malaria, we performed magnetic resonance imaging (MRI) of the brain in Japanese macaques (Macaca fuscata) infected with Plasmodium coatneyi, a primate model of severe human malaria with cerebral involvement. Although the monkey exhibited severe clinical signs, MR imaging did not reveal any significant changes during the course of infection. Histopathologic examination frequently revealed preferential sequestration of PRBCs in the cerebral and cerebellum capillaries, but neither parenchymal injury nor neuronal necrosis was found in the tissues. These results suggest that heterogeneous metabolic reduction and lack of abnormalities on MRI in the acute phase of CM may be due to may be due to any avoidance mechanisms from ischemia caused by sequestration. This may be one reason why more than half of CM patients have no neurological sequelae following recovery.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol.2011
Author(s)
Sato A., Hiramoto A., Morita M., Matsumoto M., Komichi Y., Nakase Y., Tanigawa N., Hiraoka O., Hiramoto K., Hayatsu H., Higaki K., Kawai S., Masuyama A., Nojima M., Wataya Y., Kim, H.-S.
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Journal Title
Parasitol.Int.
Volume: (In press)
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Peer Reviewed
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[Journal Article] Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites.2010
Author(s)
Sawai H., Otani H., Arisue N., Palacpac N., Martins LO., Pathirana S., Handunnetti S., Kawai S., Kishino H., Horii T., Tanabe K.
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Journal Title
BMC Evol.Biol. 10
Pages: 52-52
Related Report
Peer Reviewed
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[Journal Article] Lineage-specific positive selection at the merozoite surface protein 1(msp1)locus of Plasmodium vivax and related simian malaria parasites2010
Author(s)
Sawai H., Otani H., Arisue N., Palacpac N., Martins LO., Pathirana S., Handunnetti S., Kawai S., Kishino H., Horii T., Tanabe.
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Journal Title
BMC Evol.Biol. 10
Pages: 52-52
Related Report
Peer Reviewed
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[Presentation] 次世代シーケンサーによるサルマラリア原虫 Plasmodium cynomolgi のゲノム解読2010
Author(s)
橘真一郎, 川合覚, 後藤直久, 中村昇太, 片貝祐子, 澤井裕美, 東岸任弘, 北潔, 保富康宏, 堀井俊宏, 安永照雄, 田邉和裄
Organizer
第8回感染症沖縄フォーラム
Place of Presentation
沖縄県那覇市
Year and Date
2010-02-11
Related Report
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[Presentation] Genome sequencing of a P.vivax-related monkey malaria parasite P.cynomolgi2010
Author(s)
Tachibana S-I, Kawai S, Goto N, Nakamura S, Arisue N, Katakai, Honma H, Palacpac N, Sawai H, Tougan T, Kita K, Yasutomi Y, Horii T, Yasunaga T, Tanabe K.
Organizer
The 10^<th> Awaji international forum on infection and immunity. Awaji Yumebutai International Conference Center
Place of Presentation
Hyogo, Japan 海外学会およびシンポジウム
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[Presentation] Genome sequencing of a P.vivax-related monkey malaria parasite P.cynomolgi2010
Author(s)
Tachibana S-I, Kawai S, Goto N, Nakamura S, Arisue N, Katakai, Honma H, Palacpac N, Sawai H, Tougan T, Kita K, Yasutomi Y, Horii T, Yasunaga T, Tanabe K.
Organizer
The 10^<th> Awaji international forum on infection and immunity.
Place of Presentation
Hyogo, Japan
Related Report
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[Presentation] 次世代シーケンサーによる新規マラリア原虫ゲノムの解読2010
Author(s)
橘真一郎, 川合覚, 後藤直久, 中村昇太, 片貝祐子, 澤井裕美, 東岸任弘, 北潔, 保富康宏, 堀井俊宏, 安永照雄, 田邉和裄
Organizer
第4回日本ゲノム微生物学会年会
Place of Presentation
福岡県福岡市
Related Report
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[Presentation] 新規抗マラリア薬の開発研究-環状過酸化化合物の抗マラリア活性と体内動態-2009
Author(s)
松本雅弘, 岡田和朗, 脇本達也, 笹岡健二, 森田将之, 小山貴彦, 益山新樹, 野島正明, 川合覚, 平岡修, 平本一幸, 平本晃子, 佐藤聡, 金恵淑, 綿矢有佑
Organizer
第8回分子寄生虫・マラリア研究フォーラム
Place of Presentation
大阪府吹田市
Related Report
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[Presentation] アジアマカクマラリア原虫Plasmodium cynomolgiのゲノム解読2009
Author(s)
橘真一郎, 川合 覚, 後藤直久, 中村昇太, 片貝祐子, 澤井裕美, 東岸任弘, 北 潔, 保富康宏, 堀井俊宏, 安永照雄, 田邉和裄
Organizer
第78回日本寄生虫学会
Place of Presentation
東京都
Related Report
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[Presentation] 新規抗マラリア薬の開発 -抗マラリア活性を有する新規環状過酸化化合物の体内動態-2008
Author(s)
小道由香, 中瀬由佳里, 犀川優, 佐伯真希, 益山新樹, 野島正朋, 川合 覚, 片岡 洋行, 三谷公里栄, 金 惠淑, 綿矢有佑
Organizer
第77回日本寄生虫学会
Place of Presentation
長崎市
Related Report
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