Analysis of regulatory mechanism of motility essential for Entamoeba encystation and excystation
| Project/Area Number |
20590432
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MAKIOKA Asao Jikei University School of Medicine, 医学部, 准教授 (90119850)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Entamoeba / 嚢子形成 / 脱嚢 / コフィリン / プロフィリン / アクチン細胞骨格 / cytochalasin D / Arp2 / 3 |
|---|
| Research Abstract |
The encystation and excystation of Entamoeba are important processes for formation of the infective form and establishment of the infection. The present study focused on an actin depolymerizing factor cofilin and profilin, which are essential for reorganization of actin cytoskeleton, and investigated their identification, gene cloning, phylogeny, preparation of recombinant proteins, localization and expression analysis and found different expression of each molecules.
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Report
(4 results)
Research Products
(9 results)
