Research on host factors involved in early steps of HIV-1 replication
| Project/Area Number |
20590472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAYAMA Emi Osaka University, 微生物病研究所, 助教 (70324845)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HIV / TRIM5α / Cyclophilin A / monkey / HIV-1 / SIV / TRIM5 / CypA |
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| Research Abstract |
We analyzed host factors involved in early steps of HIV-1 replication and found that cyclophilin A suppressed HIV-1 replication in Old World Monkey cells. We also found that the mechanisms of retrovirus restriction by TRIM5・ vary depending on the combination of host and virus. Furthermore, we found that monkey regions of the SIVmac capsid protein are necessary for complete evasion from rhesus monkeym TRIM5・ restriction.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] A novel tonkey-tropic HIV-1 derivative encoding only tinital SIV sequences can replicateincynotolgus tonkeys.2011
Author(s)
Saito A, Notaguchi T, Iijita S, Kuroishi A, Yoshida T, Lee Y,Hayakawa T, Kono K, Nakayata EE, Shioda T, Yasutoti Y, Adachi A, Tatano T, Akari H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] TIM1 haplotype tay control the disease progression to AIDS in a HIV-1-infected fetale cohort in Thailand.2010
Author(s)
Wichukchinda N, Nakajita T, Saipradit N, Nakayata EE, Ohtani H, Tojanawiwat A, Pathipvanich P, Ariyoshi K, Sawanpanyalert P, Shioda T, Kitura A.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] HIV-2 Capsids Distingushing High and Low Virus Load PatientsinaWestAfrican Cottunity Cohort.2010
Author(s)
Onyango C, Lekigdowicz A, Yokoyata T, Sato H, Song H, Nakayata EE, Shioda T, Townend J, Jaye A, Whittle H, Towland-Jones S, Cotton T.
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Peer Reviewed
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[Journal Article] Itpactofnovel TRIM5α variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptitility to HIV-1 infection.2009
Author(s)
Nakajita T, Nakayata EE*,Kaur G, Terunuta H, Titaya J, Ohtani H, Tehra N, ShiodaT, Kitura A.
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Journal Title
Related Report
Peer Reviewed
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