Research Project
Grant-in-Aid for Scientific Research (C)
In order to clarify a role of HIV-1 Nef on the AIDS pathogenesis, we analyzed the innate immune function of macrophages through the stimulation of TLR5 and IL-10 receptor beta, expressions of which were suppressed by Nef. A cytokine production profile of macrophages via these signaling was disturbed by Nef expression. Unfortunately, immunodeficient mice reconstituted with human cord blood stem cells were poor in the macrophage development and, therefore, not a good model to study Nef function in vivo.
All 2011 2010 2009 2008 Other
All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (16 results) Book (3 results) Remarks (1 results)
Biochem.Biophy.Res.Comm.
Volume: 404 Pages: 822-828
Frontiers in Microbiology 1
Pages: 1-9
Frontiers in Microbiology
Volume: 1 Pages: 1-9
Volume: 401 Pages: 40-45
AIDS 23
Pages: 2265-2275
J.Virol. 83
Pages: 5514-5524
PLoS Pathogen 5
Microbes Infect. 11
Pages: 191-197
PLoS Pathogen. 5
BBRC 383
Pages: 340-346
Microbes Infect 11
PNAS 105
Pages: 12509-12514