Role of intestinal macrophages in the pathogenesis of intestinal lesions induced by non-steroidal anti-inflammatory drugs.
| Project/Area Number |
20590550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
KATO Shinichi Kyoto Pharmaceutical University, 薬学部, 准教授 (90281500)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非ステロイド性抗炎症薬(NSAID) / マクロファージ / 消化管傷害 / α7ニコチン性アセチルコリン受容体 / 内皮型NO合成酵素 / 一酸化窒素(NO) / 消化管マクロファージ / 内皮型NO合成酵素(eNOS) / 一酸化窒素 / α7ニコチンアセチルコリン受容体 / 腸管マクロファージ / 小腸障害傷害 / 誘導型NO合成酵素(iNOS) |
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| Research Abstract |
In the present study, we investigated the role intestinal macrophages in the pathogenesis of gastrointestinal diseases.
1. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) suppresses the severity of intestinal lesions induced by non-steroidal anti-inflammatory drugs (NSAID).
2. Dopamine D2 receptor antagonists significantly prevent NSAID-induced intestinal lesions through activation ofα7nAChR.
3. The aggravation of NSAID-induced gastric damage during arthritis is attributable to the upregulation of iNOS and eNOS.
4. Lansoprazole, a proton pump inhibitor, protects NSAID-induced intestinal lesions through induction of heme oxygenase (HO)-1.
5. Macrophages play a beneficial role in the healing of chronic gastric ulcers mediated by increase in neovascularization through upregulation of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF).
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats.2010
Author(s)
Yoda Y, Amagase K, Kato S, Tokioka S, Murano M, Kakimoto K, Nishio H, Umegaki E, Takeuchi K, Higuchi K.
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Journal Title
Journal of Physiology and Pharmacology 61
Pages: 287-294
Related Report
Peer Reviewed
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[Journal Article] Prevention by lansoprazole, a proton pump inhibitor, of indomethacin-induced small intestinal ulceration in rats through induction of heme oxygenase-1.2010
Author(s)
Yoda Y, Amagase K, Kato S, Tokita S, Murano K, Kakimoto H, Nishio H, Umegaki E, Takeuchi K, Higuchi K.
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Journal Title
Journal of Physiology and Pharmacology (in press)
Related Report
Peer Reviewed
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