Studies on the pathogenic mechanisms of anti-phospholipid antibodies responsible for the thrombotic formation and cell activation.
| Project/Area Number |
20590568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NOJIMA Junzo Yamaguchi University, 大学院・医学系研究科, 教授 (30448071)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIHARA Kiyoshi 山口大学, 大学院・医学系研究科, 教授 (10144495)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 全身性エリテマトーデス / 抗リン脂質抗体症候群 / 動脈血栓塞栓症 / 組織因子 / 単球 / 炎症性サイトカイン / 抗リン脂質抗体 / 全身性エリテマーデス / 炎症性サイトカント / 動脈硬化症 / 血栓症 / 血小板 |
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| Research Abstract |
The main objective of this study was to clarify the role of anti-phospholipid antibodies (aPL) in the pathogenesis of arterial thromboembolic complications in patients with systemic lupus erythematosus (SLE). Our study demonstrated that aPL cause persistently high TF expression and inflammatory cytokine production in the interaction of monocytes and lymphocytes, which may be an important mechanism for the pathogenesis of arterial thromboembolic complications in SLE patients with APS.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Molecular typing of Bartonella henselae DNA extracted from human clinical specimens and cat isolates in Japan.2010
Author(s)
Yanagihara M, Tsuneoka H, Hoshide S, Ishido E, Umeda A, Tsukahara M, Nojima J, Ichihara K, Hino K, Hirai I, Yamamoto Y.
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Journal Title
FEMS Immunol Med Microbiol. 60
Pages: 44-48
Related Report
Peer Reviewed
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