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Proteomic investigation of oxidized proteins in cerebrospinal fluid for developing novel biomarkers of Alzheimer's disease.

Research Project

Project/Area Number 20590594
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2009-2012)
Tokyo Metropolitan Institute of Gerontology (2008)

Principal Investigator

TODA Tosifusa  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80133635)

Co-Investigator(Renkei-kenkyūsha) NAKAMURA Magumi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究助手 (10159072)
SHIBASAKI Futoshi  財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (90300954)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords病態検査医学 / バイオマーカー / 神経変性疾患 / 髄液マーカー / 酸化タンパク質 / 認知症 / 髄液バイオマーカー / プロテオーム解析 / 臨床検査医学 / 軽度認知障害 / カルボニル化タンパク質
Research Abstract

Proteomic analysis of oxidatively modified proteins was performed on spinal fluid of Alzheimer's disease patients. As a consequence of in-gel digestion and mass spectrometric identification, it has been clarified that transthyretin is preferentially oxidized in spinal fluid of Alzheimer's disease patients. Oxidative modification of transthyretin might be involved in incidence of Alzheimer's disease.

Report

(7 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (70 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (26 results) (of which Peer Reviewed: 24 results) Presentation (42 results) Remarks (2 results)

  • [Journal Article] Differential responses of white adipose tissue and brown adipose tissue to caloric restriction in rats.2012

    • Author(s)
      Okita N, Hayashida Y, Kojima Y, Fukushima M, Yuguchi K, Mikami K, Yamauchi A, Watanabe K, Noguchi M, Nakamura M, Toda T, Higami Y.
    • Journal Title

      Mech Ageing Dev.

      Volume: 133(5) Issue: 5 Pages: 255-266

    • DOI

      10.1016/j.mad.2012.02.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging2012

    • Author(s)
      Toda T, Nakamura M, Morisawa H, Hirota M, Nishigaki R, Yoshimi Y.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 10(Suppl.1)

    • NAID

      10027272777

    • Related Report
      2012 Final Research Report
  • [Journal Article] Galectin-7 as a marker of cholesteatoma residue and its detection during surgery by an immunofluorescent methodva preliminary study2012

    • Author(s)
      高木大樹
    • Journal Title

      Ontology and Neurotology

      Volume: 33 Issue: 3 Pages: 396

    • DOI

      10.1097/mao.0b013e3182488021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of differentially expressed genes during differentiation of cynomolgus monkey (Macaca fascicularis) embryonic stem cells to astrocyte progenitor cells in vitro.2012

    • Author(s)
      赤間邦子
    • Journal Title

      Biochimimica et Biophysica Acta

      Volume: 1834 Issue: 2 Pages: 601-610

    • DOI

      10.1016/j.bbapap.2012.12.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus2011

    • Author(s)
      Kuramitsu Y, Takashima M, Yokoyama Y, Iizuka N, Tamesa T, Akada JK, Wang Y, Toda T, Sakaida I, Okita K, Oka M, Nakamura K.
    • Journal Title

      Anticancer Res.

      Volume: 31(10) Pages: 3331-3336

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including alpha-actinin 42011

    • Author(s)
      Akimoto Y, Miura Y, Toda T, Wolfert MA, Wells L, Boons G-J, Hart GW, Endo T, Kawakami H
    • Journal Title

      Clin Proteomics.

      Volume: 8(15) Issue: 1 Pages: 1-16

    • DOI

      10.1186/1559-0275-8-15

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative evaluation of lectin-reactive glycoforms of alpha1-acid glycoprotein using lectin affinity capillary electrophoresis with fluorescence detection2011

    • Author(s)
      Shimura K, Tamura M, Toda T, Yazawa S, Kassai K
    • Journal Title

      Electrophoresis

      Volume: 32(16) Issue: 16 Pages: 2188-2193

    • DOI

      10.1002/elps.201100146

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of two types of exosomes in human whole saliva2011

    • Author(s)
      Ogawa Y, Miura Y, Harazono A, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamaguchi T, Toda T, Endo T, Tsubuki M., Yanoshita R.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 34(1) Pages: 13-23

    • NAID

      130000402256

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] proteomic identification of differentially expressed genes in neural stem cells and neurons differentiated from embryonic stem cells of cynomolgus monkey (Macaca fascicularis) in vitro2011

    • Author(s)
      Akama K, Horikoshi T, Nakayama T, Otsu M, Imaizumi N, Nakamura M, Toda T, Inuma M, Hirano H, Kondo Y, Suzuki Y, Inoue N.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1814 Issue: 2 Pages: 265-276

    • DOI

      10.1016/j.bbapap.2010.10.009

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of plasma proteins in Japanese semisuper centenarians2011

    • Author(s)
      Miura Y, Sato Y, Arai Y, Abe Y, Takayama M, Toda T, Hirose N, Endo T.
    • Journal Title

      Exp Gerontol.

      Volume: 46 Issue: 1 Pages: 81-85

    • DOI

      10.1016/j.exger.2010.10.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including alpha-actinin 42011

    • Author(s)
      秋元義弘
    • Journal Title

      Clinical Proteomics

      Volume: 8 Pages: 1-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of plasma proteins in Japanese semisuper centenarians2011

    • Author(s)
      Miura Y, Sato Y, Arai Y, Abe Y, Takayama M, Toda T, Hirose N, Endo T.
    • Journal Title

      Experimental Gerontology. 46

      Pages: 81-85

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of plasma proteins in Japanese semisuper centenarians2011

    • Author(s)
      Miura Y, Sato Y, Arai Y, Abe Y, Takayama M, Toda T, Hirose N, Endo T
    • Journal Title

      Experimental Gerontology

      Volume: 46 Pages: 801-885

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme.2010

    • Author(s)
      Akama K, Horikoshi T, Sugiyama A, Nakahata S, Akitsu A, Niwa N, Intoh A, Kakui Y, Sugaya M, Takei K, Imaizumi N, Sato T, Matsumoto R, Iwahashi H, Kashiwabara SI, Baba T, Nakamura M, Toda T.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1804(6) Issue: 6 Pages: 1272-1284

    • DOI

      10.1016/j.bbapap.2010.02.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging2010

    • Author(s)
      Toda T, Nakamura M, Morisawa H, Hirota M, Nishigaki R, Yoshimi Y.
    • Journal Title

      Geriatrics Gerontology International 10(Supplement 1)

    • NAID

      10027272777

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Protein disulfide isomerase-P5, down-regulated in the final stage of boar epididymal sperm maturation, catalyzes disulfide formation to inhibit protein function in oxidative refolding of reduced denatured lysozyme2010

    • Author(s)
      Akama K, Horikoshi T, Sugiyama A, Nakahata S, Akitsu A, Niwa N, Intoh A, Kakui Y, Sugaya M, Takei K, Imaizumi N, Sato T, Matsumoto R, Iwahashi H, Kashiwabara SI,Baba T, Nakamura M, Toda T.
    • Journal Title

      Biochimica et Biophysics Acta

      Volume: 1804 Pages: 1272-1284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging2010

    • Author(s)
      Toda T, Nakamura M, Morisawa H, Hirota M, Nishigaki R, Yoshimi Y.
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 10(Supp1.1)

    • NAID

      10027272777

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis : An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress2009

    • Author(s)
      Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T.
    • Journal Title

      Exp. Gerontol.

      Volume: 44(6-7) Pages: 375-382

    • URL

      http://dx.doi.org/10.1016/j.exger.2009.02.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocryst alglobulin in a patient of multiple myeloma2009

    • Author(s)
      Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Mori M.
    • Journal Title

      J. Electrophoresis

      Volume: 53 Pages: 1-6

    • NAID

      10025191936

    • URL

      http://dx.doi.org/10.2198/jelectroph.53.7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis : An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress2009

    • Author(s)
      Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T
    • Journal Title

      Experimental.Gerontology 44(6-7)

      Pages: 375-382

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis : An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress2009

    • Author(s)
      Nakamura M, Morisawa H, Imajoh-Ohmi S, Takamura C, Fukuda H, Toda T
    • Journal Title

      Experimental Gerontology 44

      Pages: 375-382

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Galectin-3 with Vacular Cell Adhesion Molecule-1 in Growth Regulation of Mouse BALB/3T3 cells2009

    • Author(s)
      Tadokoro T, Ikekita M, Toda T, Ito H, Sato T, Nakatani R, Hamaguchi Y, Furukawa K
    • Journal Title

      Journal of Biological Chemistry 284

      Pages: 35556-35563

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラミンA-その多彩な機能と老化-2009

    • Author(s)
      中村愛、森澤拓、戸田年総
    • Journal Title

      基礎老化研究 33

      Pages: 3-10

    • NAID

      10026103704

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycoproteomic analysis of abnormal N-glycosylation on the kappa chain of cryocryst alglobulin in a patient of multiple myeloma2009

    • Author(s)
      Toda T, Nakamura M, Yamada M, Nishine T, Torii T, Ikenaka K, Mori M.
    • Journal Title

      J. Electrophoresis 53

      Pages: 1-6

    • NAID

      10025191936

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic identification of differentially expressed genes in ouse neural stem cells and neurons differentiated from embryonic stem cells in vitro2008

    • Author(s)
      Akama K, Tatsuno R. Otsu M, Horikoshi T, Nakamura M, Toda T, Inoue N
    • Journal Title

      Biochim. Biophys. Acta. 1784

      Pages: 773-782

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Glycopetides Using Lectin Affinity Chromatography with MALDI-TOF Mass Spectrometry2008

    • Author(s)
      Kubota K, Sato Y, Suzuki Y, Goto-Inoue N, Toda T, Suzuki M, Endo T.
    • Journal Title

      Anal. Chem. 80

      Pages: 3693-3698

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糖尿病性腎症に伴うタンパク質への糖修飾異常の解析2013

    • Author(s)
      秋元義弘
    • Organizer
      第118回日本解剖学会総会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析データリポジトリの開発2012

    • Author(s)
      森 澤拓、廣田三佳子、岩本真知子、三浦ゆり、戸田年総
    • Organizer
      第10回JHUPO日本プロテオーム学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Proteomic identification of differentially expressed genes during differentiation of cynomolgus monkey embryonic stem cells to astrocyte progenitor cells in vitro2012

    • Author(s)
      Kuniko Akama1, Tomoe Horikoshi, Takashi Nakayama, Masahiro Otsu, Noriaki Imaizumi, Megumi Nakamura, Tosifusa Toda, Michiko Inuma, Hisashi Hirano, Yasushi Kondo, Yutaka Suzuki, Nobuo Inoue
    • Organizer
      HUPO 11th Annual World Congress
    • Place of Presentation
      ボストン、米国
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病角膜症に伴うタンパク質への糖(O-GlcNAc)修飾の変化2012

    • Author(s)
      秋元義弘
    • Organizer
      日本顕微鏡学会第68回学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of O-GlcNAcylated Proteins by Glycoproteomics and in situ Proximity Ligation Assay (PLA)2012

    • Author(s)
      秋元義弘
    • Organizer
      第14回国際組織細胞化学会議
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proteomic identification of differentially expressed genes during differentiation of cynomolgus monkey embryonic stem cells to astrocyte progenitor cells in vitro2012

    • Author(s)
      赤間邦子
    • Organizer
      HUPO 11th Annual World Congress
    • Place of Presentation
      ボストン
    • Related Report
      2012 Annual Research Report
  • [Presentation] プロテオーム解析による健康長寿マーカーの探索---日本人超百寿者血漿の網羅的解析---2011

    • Author(s)
      三浦ゆり、新井康通、戸田年総、広瀬信義、遠藤玉夫
    • Organizer
      日本基礎老化学会第34回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] プロテオミクス用研究情報管理システムにおける電気泳動画像データ、質量分析データの表示、再解析機能の開発2011

    • Author(s)
      森澤 拓、廣田三佳子、岩本真知子、戸田年総
    • Organizer
      日本ヒトプロテオーム機構第9回大会(日本プロテオーム学会2011年会)
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report
  • [Presentation] 日本人超百寿者血漿タンパク質のプロテオミクス2011

    • Author(s)
      三浦ゆり、新井康通、戸田年総、広瀬 信義、遠藤 玉夫
    • Organizer
      日本ヒトプロテオーム機構第9回大会(日本プロテオーム学会2011年会)
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] メチオニンスルホキシドペプチドを標的としたフォーカストプロテオミクスによる細胞内酸化ストレス動態の網羅的解析2011

    • Author(s)
      戸田年総、岩本真知子、森澤拓、中家修一、尾島典行
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 二次元電気泳動分離スポットの質量分析による酸化メチオニンレベルの定量~タンパク質酸化修飾指標としての有用性について~2011

    • Author(s)
      戸田年総、岩本真知子、森澤拓、中家修一、尾島典行
    • Organizer
      第62回日本電気泳動学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 新規細胞死誘導剤リダイフェン-Gの薬物標的分子の同定2011

    • Author(s)
      羽鳥麻奈美
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全自動二次元電気泳動装置を使用した14-3-3タンパク質アイソフォームの解析2011

    • Author(s)
      岩本真知子
    • Organizer
      第62回日本電気泳動学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテオーム用研究情報管理システムの拡張-再解析機能ツールの開発-2011

    • Author(s)
      森澤拓
    • Organizer
      第62回日本電気泳動学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロテオーム解析に利用可能な病理解剖組織バンク(病理解剖バイオバンク)事業の開始2011

    • Author(s)
      沢辺元司
    • Organizer
      日本ヒトプロテオーム機構第9回大会(日本プロテオーム学会2011年会)
    • Place of Presentation
      新潟
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neural stem sphere法によるサルの初期神経発生のプロテオーム解析2010

    • Author(s)
      赤間邦子、堀越朋恵、中山 孝、大津昌弘、今泉紀明、中村 愛、戸田年総、近藤 靖、鈴木 豊、井上順雄
    • Organizer
      第53回日本神経化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 酸化ストレスによるラミンのリン酸化と分子シャペロン複合体形成のプロテオーム解析2010

    • Author(s)
      戸田年総、中村 愛
    • Organizer
      日本電気泳動学会第62回総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 脳脊髄液タンパク質の酸化還元状態の多角的プロテオーム解析2010

    • Author(s)
      戸田年総、岩本真知子、森澤 拓、吉澤利弘、芝崎 太
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会連合大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report 2010 Annual Research Report 2010 Self-evaluation Report
  • [Presentation] ラット白色および褐色脂肪組織におけるカロリー制限に体する応答性の違い2010

    • Author(s)
      林田雄介、福島麻由美、小島由美子、沖田直之、中村愛、戸田年総、樋上賀一
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテオーム用研究情報管理システムの改良とGelML2010

    • Author(s)
      森澤拓、廣田三佳子、戸田年総
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Related Report
      2010 Annual Research Report
  • [Presentation] ブタ精子成熟過程におけるユビキチン化タンパク質の効率的抽出濃縮法2010

    • Author(s)
      今泉紀明、井沼道子、平野久、中村愛、戸田年総、肥後大輔、赤間邦子
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Related Report
      2010 Annual Research Report
  • [Presentation] O-GlcNAc-Modification of the Proteins in Diabetic Cornea2010

    • Author(s)
      kimoto Y, Yuri Miura Y, Toda T, Yamamoto K, Munetomo E, Hart G W, Endo T, Hayato Kawakami H.
    • Organizer
      Glyco T 2010 (7th International Symposium on Glyco syltransferase)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化ストレスによるラミンのリン酸化と分子シャペロン複合体形成のプロテオーム解析2010

    • Author(s)
      戸田年総、中村愛
    • Organizer
      第61回日本電気泳動学会総会
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アポトーシス誘導剤リダイフェン-Gの薬物標的分子の同定2010

    • Author(s)
      羽鳥麻奈美、森田明典、椎名勇、中田健也、戸崎雄太、王エンブン、戸田年総、大篭友博、矢守隆夫、池北雅彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会連合大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Protein isoasparatyl methyltransferase gene knock down induced human alveolar epithelial to mesenchymal cell transition through endoplasmic reticulum stress2010

    • Author(s)
      小笠原正人、戸田年総、韮澤悟、前山一隆、高橋砂織、山内広平
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会連合大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化ストレス負荷におけるSH-SY5Y細胞のブルーネイティブ二次元電気泳動によるプロテオーム解析(II)2009

    • Author(s)
      中村愛, 森澤拓, 戸田年総
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report 2009 Annual Research Report
  • [Presentation] 質量分析データビュワーの改良--プロテオーム研究情報管理のために--2009

    • Author(s)
      森澤拓, 中村愛, 廣田三佳子, 戸田年総
    • Organizer
      日本ヒトプロテオーム機構第7回会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Proteome Analysis of Carbonyl Proteins in Cerebrospinal Fluid by Cy5-Hydrazide Labeling2009

    • Author(s)
      Tosifusa Toda, Megumi Nakamura, Futoshi shibasaki, Toshihiro Yoshizawa
    • Organizer
      HUPO 8th Annual World Congress
    • Place of Presentation
      Tronto、Canada
    • Related Report
      2012 Final Research Report 2010 Self-evaluation Report
  • [Presentation] Neural StemSphere法を用いたサルES細胞から神経幹細胞への分化過程における発現量変化解析2009

    • Author(s)
      今泉紀明, 堀越朋恵, 中山孝, 大津昌弘,赤間邦子, 中村愛, 戸田年総, 近藤靖, 鈴木豊, 井上順雄
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 二次元目にTris-Tricine緩衝液系SDS-電気泳動を用いた場合のスタッキング効果に影響を及ぼす緩衝液条件の検討:ミニゲル二次元電気泳動のための泳動条件の最適化2009

    • Author(s)
      戸田年総, 中村愛, 廣田三佳子, 森澤拓
    • Organizer
      第60回日本電気泳動学会総会
    • Place of Presentation
      松本
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Tokyo Metropolitan Geriatric Hospital Autopsy Resource (TMGH-AR)2009

    • Author(s)
      Motoji Sawabe, Tomio Arai, Yuko Saito, Takahiko Shimizu, Tosifusa Toda, Shigeo Murayama, Masashi Tonaka, Kaiyo Takubo, Makiko Naka, Noriko Tanaka
    • Organizer
      19th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Paris、France
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Release of New Web Site for Tokyo Metropolitan Geriatric Hospital Autopsy Resource(TMGH-AR)2009

    • Author(s)
      Sawabe M, Arai T, Saito Y, Shimizu T, Toda T, Murayama S, Tanaka M, Tokubo K, Naka M, Tanaka N
    • Organizer
      ISBER 2009 Annual Meeting & Exhibits
    • Place of Presentation
      Portland, Oregon, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tokyo Metropolitan Geriatric Hospital Autopsy Resource(TMGH-AR)2009

    • Author(s)
      Sawabe M, Arai T, Saito Y, Shimizu T, Toda T, Murayama S, Tanaka M, Tokubo K, Naka M, Tanaka N
    • Organizer
      19th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Paris、France
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Stem Sphere 法を用いたサルES細胞から神経への分化における発現比較解析2009

    • Author(s)
      今泉紀明, 堀越朋恵, 中山孝, 大津昌弘, 赤間邦子, 中村愛, 戸田年総, 近藤靖, 鈴木豊, 井上順雄
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 質量分析データビュワーの改良-プロテオーム研究情報管理のために-2009

    • Author(s)
      森澤拓, 中村愛, 廣田三佳子, 戸田年総
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二時限目に Tris-Tricine 緩衝液系SDS-電気泳動を用いた場合のスタッキング効果に影響を及ぼす緩衝液条件の検討2009

    • Author(s)
      戸田年総, 中村愛, 廣田三佳子, 森澤拓
    • Organizer
      第60回日本電気泳動学会総会
    • Place of Presentation
      松本
    • Related Report
      2009 Annual Research Report
  • [Presentation] Proteome Analysis of Carbonyl Proteins in Cerebrospinal Fluid by Cy5-Hyedrazide Labeling2009

    • Author(s)
      Toda T, Nakamura M, Shibasaki FT, Yoshizawa T.
    • Organizer
      HUPO 8th Annual World Congress
    • Place of Presentation
      Tronto、Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト唾液中に存在する2種類のエキソソームのプロテオーム解析2009

    • Author(s)
      小川裕子, 三浦ゆり, 原園景, 金井正美, 戸田年総, 遠藤玉夫, 山口照英, 秋元義弘, 川上速人, 津吹政可, 矢ノ下良平
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neural Stem Sphere 法を用いたサルES細胞から神経幹細胞への分化過程における発現量変化解析2009

    • Author(s)
      今泉紀明, 堀越朋恵, 中山孝, 大津昌弘, 赤間邦子, 中村愛, 戸田年総, 近藤靖, 鈴木豊, 井上順雄
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] シアニン系蛍光標識試薬を用いたタンパク質フリーチオールレベルの定量分析法に関する基礎的検討2008

    • Author(s)
      戸田年総, 中村愛, 森澤拓, 岩本真知子
    • Organizer
      第59回日本電気泳動学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] An approach to the quantitative analysis of free thiol levels in human CSF proteins by the method of 2-D gel fluoroimaging with using cyanine dyes and fluorescent gel stain2008

    • Author(s)
      Tosifusa Toda, Megumi Nakamura, Hiraku Morisawa, Machiko Iwamoto, Junpei Ohkata, Hajime Sato, Hiroshi Tanaka, Kazutomi Kanemaru
    • Organizer
      MPSA2008 17th Meeting of Methods in Protein Structure Analysis
    • Place of Presentation
      札幌
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Development of Autopsy Bioresource for Medical Research2008

    • Author(s)
      Sawabe M, Arai T, Kasahara I, Saito Y, Toda T, et al.
    • Organizer
      ISBER 2008 Annual Meeting & Exhits
    • Place of Presentation
      Bethesda, Maryland, USA
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://proteome.tmig.or.jp/2D/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://proteome.tmig.or.jp/2D/

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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