Modeling and inter-individual difference of pharmacokinetics of persistent organofluorine compounds
| Project/Area Number |
20590597
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyoto University |
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Principal Investigator |
HARADA Kouji Kyoto University, 大学院・医学研究科, 准教授 (80452340)
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| Co-Investigator(Renkei-kenkyūsha) |
KOIZUMI Akio 京都大学, 大学院・医学研究科, 教授 (50124574)
MINATA Mutsuko 京都大学, 大学院・医学研究科, 助教 (00456857)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 衛生 / 環境 / 分析化学 / 社会医学 / 薬学 / 薬物動態学 / 分析科学 |
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| Research Abstract |
Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical. PFOA shows extremely long half-life in humans. Long chain homologues in serum were increased in a decade. We developed toxicokinetics model and modeling of serum levels in general population agreed with observed levels. We found a large renal excretion of PFOA in Abcb4-deficient mice and using a microarray approach ATP-binding cassette, sub-family B, member 1B (Abcb1b) was shown to be a renal transporter of PFOA using abcb1a/1b null mice.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan.2011
Author(s)
Fujii Y, Haraguchi K, Harada KH, Hitomi T, Inoue K, Itoh Y, Watanabe T, Takenaka K, Uehara S, Yang HR, Kim MY, Moon CS, Kim HS, Wang P, Liu A, Hung NN, Koizumi A.
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Journal Title
Chemosphere 82
Pages: 25-31
Related Report
Peer Reviewed
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[Journal Article] Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008.2010
Author(s)
Harada KH, Yang HR, Moon CS, Hung NN, Hitomi T, Inoue K, Niisoe T, Watanabe T, Kamiyama S, Takenaka K, Kim MY, Watanabe K, Takasuga T, Koizumi A.
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Journal Title
Chemosphere 79
Pages: 314-9
Related Report
Peer Reviewed
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[Journal Article] Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan.2009
Author(s)
Koizumi A, Harada KH, Eslami B, Fujimine Y, Hachiya N, Hirosawa I, Inoue K, Inoue S, Koda S, Kusaka Y, Murata K, Omae K, Saito N, Shimbo S, Takenaka K, Takeshita T, Todoriki H, Wada Y, Watanabe T, Ikeda M.
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Journal Title
Environ Health Prev Med 14
Pages: 235-46
NAID
Related Report
Peer Reviewed
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[Journal Article] Reconstruction of human exposure to heavy metals using synchrotron radiation microbeams in prehistoric and modern humans.2009
Author(s)
Koizumi A, Azechi M, Shirasawa K, Saito N, Saito K, Shigehara N, Sakaue K, Shimizu Y, Baba H, Yasutake A, Harada K, Yoshinaga T, Ide-Ektessabi A.
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Journal Title
Environmental Health and Preventive Medicine 14
Pages: 52-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Levels and regional trends of persistent organochlorines and polybrominated diphenyl ethers in Asian breast milk demonstrate POPs signatures unique to individual countries.2009
Author(s)
Haraguchi K, Koizumi A, Inoue K, Harada KH, Hitomi T, Minata M, Tanabe M, Kato Y, Nishimura E, Yamamoto Y, Watanabe T, Takenaka K, Uehara S, Yang HR, Kim MY, Moon CS, Kim HS, Wang P, Liu A, Hung NN.
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Journal Title
Environ Int 35
Pages: 1072-9
Related Report
Peer Reviewed
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[Presentation] POPs IN DIETARY SAMPLES FROM CHINA, KOREA AND JAPAN-TRENDS OF LEGACY & NEW POPs COMPARED TO POPs CANDIDATES, DIOXIN2010.2010
Author(s)
Takasuga T, Nouda C, Matsukami H, Takemori H, Harada K, Fujii Y, Hitomi T, Watanabe T, Yang HR, Moon CS, Wang P, Koizumi A
Organizer
the 30th International Symposium on Halogenated Environmental Organic Pollutants and Persistent Organic Pollutants (POPs)
Place of Presentation
Texas, USA
Related Report
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