Understanding the mechanism of liver carcinogenesis and strategy for the prevention of hepatoma development
| Project/Area Number |
20590615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tokai University |
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Principal Investigator |
WATANABE Tetsu Tokai University, 医学部, 教授 (10129744)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 予防医学 / 脂肪肝 / 肝発癌 / 酪酸菌 |
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| Research Abstract |
The CDAA diet induced NASH in Fisher rats, characerized by steatois, ilammation, fibrosis, and cirrosis in the liver. Serum level of endotoxin in the portal vein and lipoperoxidation in the liver were observe at 2 month of CDAA diet. On the contrary, treatment of rats with Clostridium butyricum in CDAA diet markedly improved liver fibrosis and lowered the level of endotoxin and GST-P. Alteration of the intestinal flora and butyrate produced by Clostridium butyricum may involve in these protective response to the NASH progression.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] ELISA measurement for urinary 3-Hydroxyproline-containing peptides and its preliminary application to healthy persons and cancer patients.2010
Author(s)
Junichi Saito, Yasutada Imamura, Joji Itoh, Shigeo Matsuyama, Akie Maruta, Toshihiko Hayashi, Ataru Sato, Norihito Wada, Kazuo Kashiwazaki, Yutaka Inagaki, Tetsu Watanabe, Yuko Kitagawa, Isao Okazaki
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Journal Title
Anticancer Research 30
Pages: 1007-1014
Related Report
Peer Reviewed
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