Gene-gene and gene-environment interactions between polymorphisms in alcohol-metabolizing enzyme genes and the risk of gastric cancer

• Project/Area Number: 20590624
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Okayama University
• Principal Investigator: HIRAKI Akio Okayama University, 医学部, 客員研究員 (70443455)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 胃がんリスク / 胃がん / 罹患リスク

Research Abstract

H.pylori seropositivity in the controls was not significantly associated with the AICDA 7888 C/T genotypes. Among the H. pylori seropositive control subjects, the age and sex-adjusted ORs of atrophic gastritis were not statistically significant. The age- and sex-adjusted ORs of gastric cancer relative to atrophic gastritis were also not statistically significant. The hypothetical association of the AICDA 7888 C/T polymorphism with the risk of gastric cancer or gastric atrophy was not shown in this study.

Research Products

• [Journal Article] No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. (2010)
  • Author(s): Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
  • Journal Title: Gastric Cancer. 13(1) Pages: 43-49
• [Journal Article] No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. (2010)
  • Author(s): Hishida A, Hiraki A, et al.
  • Journal Title: Gastric Cancer. Volume: 13 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese. (2009)
  • Author(s): Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
  • Journal Title: Helicobacter. 14(1) Pages: 47-53
• [Journal Article] Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. (2009)
  • Author(s): Kanda J, Matsuo K, Suzuki T, Kawase T, Hiraki A, Watanabe M, Mizuno N, Sawaki A, Yamao K, Tajima K, Tanaka H.
  • Journal Title: Cancer Sci. 100(2) Pages: 296-302
• [Journal Article] Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese. (2009)
  • Author(s): Matsuo K, Tajima K, Suzuki T, Kawase T, Watanabe M, Shitara K, Misawa K, Ito S, Sawaki A, Muro K, Nakamura T, Yamao K, Yamamura Y, Hamajima N, Hiraki A, Tanaka H.
  • Journal Title: Int J Cancer. 125(8) Pages: 1961-1964
• [Journal Article] Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. (2009)
  • Author(s): Kawase T, Matsuo K, Hiraki A, Suzuki T, Watanabe M, Iwata H, Tanaka H, Tajima K.
  • Journal Title: J Epidemiol. 19(5) Pages: 244-250
• [Journal Article] Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009)
  • Author(s): Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 18(11) Pages: 3097-3102
• [Journal Article] Aldehyde dehydrogenase 2 and head and neck cancer : a meta-analysis implementing a Mendelian randomization approach. (2009)
  • Author(s): Boccia S, Hashibe M, Galli P, De Feo E, Asakage T, Hashimoto T, Hiraki A, Katoh T, Nomura T, Yokoyama A, van Duijn CM, Ricciardi G, Boffetta P.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 18(1) Pages: 248-254
• [Journal Article] Toll-like receptor 4+3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese. (2009)
  • Author(s): Hishida A, Matsuo K. Goto Y, Mi
  • Journal Title: Helicobacter 14 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Alcohol drinking and one-carbon metabolism- related gene polymorphisms on pancreatic cancer risk. (2008)
  • Author(s): Suzuki T, Matsuo K, Sawaki A, Mizuno N, Hiraki A, Kawase T, Watanabe M, Nakamura T, Yamao K, Tajima K, Tanaka H.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17(10) Pages: 2742-2747