Development of therapeutics for dementia targeting Abeta clearance

• Project/Area Number: 20590697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: SATO Naoyuki Osaka University, 大学院・医学系研究科, 寄付講座准教授 (70372612)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アルツハイマー病 / ベータ / アミロイド / ベータ・アミロイド / クリアランス / LRP-1 / 蛋白輸送 / 離散

Research Abstract

We found that statin reduced Abeta level in mouse brain and identify its mechanism. Statin inhibited Abeta production and up-regulated Abeta clearance. Up-regulation of Abeta clearance seemed likely to be mediated by the increase of LRP-1 expression. Inhibition of protein isoprenylation is involved in both inhibition of Abeta production and up-regulation of Abeta clearance.

Research Products

• [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus : a missing link to therapeutic potential. (2011)
  • Author(s): Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R.
  • Journal Title: Current Aging Science in Press
  • Peer Reviewed
• [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse with diabetes. (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Proceeding of National Academy of Sciences of United States of America 107 Pages: 7036-41
  • Peer Reviewed
• [Journal Article] Plasma β-amyloid as potential biomarker of Alzheimer disease : possibility of diagnostic tool for Alzheimer disease. (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Journal Title: Molecular BioSystems 6 Pages: 1760-6
  • Peer Reviewed
• [Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance. (2010)
  • Author(s): Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
  • Journal Title: The Journal of Biological Chemistry 285 Pages: 22091-102
  • Peer Reviewed
• [Journal Article] Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus : a missing link to therapeutic potential. (2010)
  • Author(s): Sato N, Takeda S, Uchio-Yamada K, Ueda H, Fujisawa T, Rakugi H, Morishita R.
  • Journal Title: Current Aging Science Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance (2010)
  • Author(s): Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
  • Journal Title: The Journal of Biological Chemistry Volume: 285 Pages: 22091-102
  • Peer Reviewed
• [Journal Article] Plasma β-amyloid as potential biomarker of Alzheimer disease : possibility of diagnostic tool for Alzheimer disease (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Journal Title: Molecular BioSystems Volume: 6 Pages: 1760-6
  • Peer Reviewed
• [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse with diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Proceeding of National Academy of Sciences of United States of America Volume: 107 Pages: 7036-41
  • Peer Reviewed
• [Journal Article] Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Ass deposition in an Alzheimer mouse model with diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Proceedings of National Academy of Sciences of United States of America (In press)
  • Peer Reviewed
• [Journal Article] Elevation of Plasma β-amyloid level by Glucose Loading in Alzheimer Mouse Models. (2009)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Biochemical and Biophysical Research Communications 385 Pages: 193-197
  • Peer Reviewed
• [Journal Article] Validation of Aβ1-40 Administration into Mouse Cerebroventricles as an Animal Model for Alzheimer Disease. (2009)
  • Author(s): Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R.
  • Journal Title: Brain Research 1280 Pages: 137-147
  • Peer Reviewed
• [Journal Article] Prevention of dementia by antihypertensive drugs : how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients and ACE-inhibitors. (2009)
  • Author(s): Fournier A, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N.
  • Journal Title: Expert Rev Neurother 9(9) Pages: 1413-31
  • Peer Reviewed
• [Journal Article] Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. (2009)
  • Author(s): Hayashi S, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita. R.
  • Journal Title: Arterioscler Thromb Vasc Biol. 29(説明:スライド1) Pages: 1909-15
  • Peer Reviewed
• [Journal Article] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated with Recovery of Neurovascular Coupling. (2009)
  • Author(s): Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato K, Kano M, Ogihara T, Rakugi H, Morishita R.
  • Journal Title: Hypertension 54 Pages: 1345-52
  • Peer Reviewed
• [Journal Article] Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy (2009)
  • Author(s): Hayashi S, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R.
  • Journal Title: Arterioscler Thromb Vasc Biol. 29 Pages: 1909-15
  • Peer Reviewed
• [Journal Article] Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling (2009)
  • Author(s): Takeda S, Sato N, Takeuchi D, Kurinami H, Shinohara M, Niisato Kano M, Ogihara T, Rakugi H, Morishita R.
  • Journal Title: Hypertension 54 Pages: 1345-52
  • Peer Reviewed
• [Journal Article] Validation of Abetal-40 administration into mouse cerebroventricles as an animal model for Alzheimer disease (2009)
  • Author(s): Takeda S, Sato N, Niisato K, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Kano M, Morishita R.
  • Journal Title: Brain Res. 1280 Pages: 137-47
  • Peer Reviewed
• [Journal Article] Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling (2009)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R.
  • Journal Title: Biochem Biophys Res Commun 385 Pages: 193-7
  • Peer Reviewed
• [Journal Article] The Renin-Antagotensin system, Hypertension and cognitive dysfunction in Alzheimer's Disease : New Therapeutic Potential. (2008)
  • Author(s): Takeda S, Sato N, Ogihara T, Morishita R.
  • Journal Title: Frontiers in Bioscience 13 Pages: 2253-65
  • Peer Reviewed
• [Journal Article] Prevention of amyloid beta-induced memory impairment by fluvastatin, associated with the decrease in amyloid beta accumulation and oxidative stress in amyloid beta injection mouse model. (2008)
  • Author(s): Kurinami H, Sato N, Shinohara M, Takeuchi D, Takeda S, Shimamura M, Ogihara T, Morishita R.
  • Journal Title: Gene Therapy 15 Pages: 561-71
  • Peer Reviewed
• [Journal Article] A model of cerebrovascular injury in rats. (2008)
  • Author(s): Wakayama K, Shimamura M, Sata M, koibuchi N, Sato N, Ogihara T, Morishita R.
  • Journal Title: Neurosci Methods 175 Pages: 187-95
  • Peer Reviewed
• [Journal Article] Prevention of amyloid P-induced memory impairment by fluvastatin, associated with the decrease in amyloid βaccumulation and oxidative stress in amyloid βinjection mouse model. (2008)
  • Author(s): Kurinami H, Sato N, Shino hara M, Takeuchi D, Takeda S, Shimamura M, Ogihara T, Morishita R.
  • Journal Title: International Journal of Molecular Medicine 21 Pages: 531-537
  • Peer Reviewed
• [Journal Article] Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. (2008)
  • Author(s): Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S, Shinohara M, Suzuki S, Kojima M, Ogihara T, Morishita R.
  • Journal Title: Gene Therapy 15 Pages: 561-571
  • Peer Reviewed
• [Journal Article] A model of cerebrovascular injury in rats. (2008)
  • Author(s): Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R
  • Journal Title: J Neurosci Methods 175 Pages: 187-195
  • Peer Reviewed
• [Presentation] Dual Effects Of A Statin On Abeta Metabolism : Up-Regulation Of Degradation Of APP-CTF And Abeta Clearance. (2011)
  • Author(s): Sato N, Shinohara M, Takeda S, Rakugi H, Morishita R
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-12
• [Presentation] Dual Effects Of A Statin On Abeta Metabolism : Up-Regulation Of Degradation Of APP-CTF And Abeta Clearance (2011)
  • Author(s): Sato N, Shinohara M, Takeda S, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-12
• [Presentation] Increased Blood-Brain Barrier Vulnerability To Systemic Inflammation In Alzheimer Disease Mouse Model (2011)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-10
• [Presentation] Increased Blood-Brain Barrier Vulnerability To Systemic Inflammation In Alzheimer Disease Mouse Model (2011)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2011-03-10
• [Presentation] Mechanistic Interaction Between Alzheimer Disease And Diabetes Mellitus : Analysis Of Novel Mouse Models Of Alzheimer Disease With Diabetes (2011)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
• [Presentation] Alternation In Plasma Beta-Amyloid Levels After Glucose Loading Could Be A Novel Diagnostic Marker For Alzheimer Disease S. (2011)
  • Author(s): Takeda S, Sato N, Yu H, Moriguchi A, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: The 10th International Conference on Alzheimer's & Parkinson's Diseases
  • Place of Presentation: Barcelona, Spain
• [Presentation] Diabetes accelerates memory dysfunction via cerebrovascular dysfunction in an Alzheimer mouse model with diabetes (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-03
• [Presentation] 糖代謝が血中β・アミロイド蛋白(Aβ)量に与える影響の検討:アルツハイマー病の新規診断指標への応用 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、湯久浩、守口篤、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-02
• [Presentation] スタチンによるアルツハイマー病予防効果の機序の解明 (2010)
  • Author(s): 里直行、篠原充、島村 宗尚、武田朱公、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] アンジオテンシンII受容体拮抗薬はAβによる脳血管反応性障害を抑制しアルツハイマー病モデルマウスの認知機能障害を改善する (2010)
  • Author(s): 武田朱公、里直行、荻原俊男、狩野方伸、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model (2010)
  • Author(s): 武田朱公、里直行、楽木宏実、森下竜一
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] 症病棟入院患者の周辺症状に対する抑肝散、非定型抗精神病薬、アンジオテンシン受容体拮抗薬の効果の検討 (2010)
  • Author(s): 里直行、武田朱公、湯久浩、守口篤、楽木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 認知症病棟入院患者の周辺症状に対する抑肝散、非定型抗精神病薬、アンジオテンシン受容体拮抗薬の効果の検討 (2010)
  • Author(s): 里直行、武田朱公、湯久浩、守口篤、楽木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 糖・エネルギー代謝が血中Abeta値に与える影響とその診断的応用 (2010)
  • Author(s): 武田朱公、里直行、湯久浩、守口篤、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 新規マイクロダイアライシス回収システムによる脳内ペプチドin vivo測定系の開発 (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] Increased blood-brain barrier vulnerability to systemic inflammation in Alzheimer disease mouse model (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] 短期間の高カロリー食負荷はアルツハイマー病モデルマウスの認知機能障害を改善する (2010)
  • Author(s): 武田朱公、里直行、樂木宏実、森下竜一
  • Organizer: 第21回日本老年医学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-20
• [Presentation] Possible Mutual Interaction Between Diabetes Mellitus and Alzheimer Disease : Generation of Novel Transgenic Mice Models of Alzheimer Disease With Diabetes (2010)
  • Author(s): Sato N, Takeda S, Rakugi H, Morishita R.
  • Organizer: AHA Scientific Sessions 2010
  • Place of Presentation: Chicago, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] Increased brain vulnerability to systemic inflammation in Alzheimer disease transgenic mouse model (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Organizer: The 40th annual meeting of the Society for Neuroscience (Neuroscience 2010)
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2010-11-15
• [Presentation] アルツハイマー病における血管性危険因子による病態修飾機序の解明 (2010)
  • Author(s): 武田朱公、里直行、荻原俊夫、楽木宏実、森下竜一
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-17
• [Presentation] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Memory Impairment Associated with Recovery of Neurovascular Coupling. (2010)
  • Author(s): Takeda S, Sato N, Kano M, Ogihara T, Rakugi H, Morishita R
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Memory Impairment Associated with Recovery of Neurovascular Coupling (2010)
  • Author(s): Takeda S, Sato N, Kano M, Ogihara T, Rakugi H, Morishita R.
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-28
• [Presentation] Diabetes Accelerated Memory Dysfunction via Cerebrovascular Inflammation and Beta-Amyloid Deposition in Alzheimer Mouse Model : Generation of Novel Transgenic Mouse Models of Alzheimer Disease with Diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Rakugi H, Morishita R.
  • Organizer: 23rd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2010-09-27
• [Presentation] アルツハイマー病と糖尿病の相互的病態修飾:Possible pathological interaction between diabetes mellitus and Alzheimer disease (2010)
  • Author(s): 里直行、武田朱公、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: Neuro 2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸(招待講演)
  • Year and Date: 2010-09-03
• [Presentation] アルツハイマー病病態における血管性危険因子の役割:糖尿病合併アルツハイマー病モデルマウスの解析から:Role of vascular risk factors in the pathogenesis of Alzheimer disease : Analysis of novel mouse models of Alzheimer disease with diabete (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、篠原充、楽木宏実、森下竜一
  • Organizer: Neuro 2010(第33回日本神経科学大会)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Diabetes mellitus exacerbated learning impairment via cerebrovascular inflammation and disturbance of brain insulin signaling in Alzheimer mouse models with diabetes (2010)
  • Author(s): Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Shinohara M, Rakugi H, Morishita R.
  • Organizer: Alzheimer's Association International Conference on Alzheimer Disease 2010
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2010-07-12
• [Presentation] 全身糖代謝が血中Aβ濃度に与える影響の検討:糖負荷後血中Aβの変動を利用した新たなアルツハイマー病診断指標の探索 (2010)
  • Author(s): 武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
  • Organizer: 第52回日本老年医学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] アルツハイマー病病態は末梢臓器でのインスリン抵抗性を増悪させることで糖尿病病態を増悪させる (2010)
  • Author(s): 武田朱公、里直行、藤澤智巳、楽木宏実、森下竜一
  • Organizer: 第52回日本老年医学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-26
• [Presentation] 糖尿病は脳血管障害と脳内インスリンシグナルの障害を介してアルツハイマー病脳内病態を修飾する (2010)
  • Author(s): 武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-12
• [Presentation] 糖負荷による血中Aβの変動を利用した新たなアルツハイマー病診断指標の探索:全身糖代謝が血中Aβ濃度に与える影響の検討 (2010)
  • Author(s): 武田朱公、里直行、内尾こずえ、澤田京子、國枝孝典、篠原充、楽木宏実、森下竜一
  • Organizer: 第10回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-12
• [Presentation] Mechanistic interaction between Alzheimer disease and diabetes (2010)
  • Author(s): Takeda S, Sato N, Rakugi H, Morishita R.
  • Organizer: XXth World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-05-13
• [Presentation] 糖尿病とアルツハイマー病の相互的病態修飾機序の解明:糖尿病合併アルツハイマー病モデルマウスの作成とその病態解析 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第57回日本実験動物学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-12
• [Presentation] HMG還元酵素阻害薬フルバスタチンのAβ代謝作用の解析 (2010)
  • Author(s): 篠原充、里直行、武田朱公、野間基子、森下竜一
  • Organizer: 第29回日本認知症学会総会
  • Place of Presentation: 名古屋
• [Presentation] 糖尿病合併アルツハイマー病モデルマウスにおける脳血管病態と脳内インスリンシグナルの変化 (2010)
  • Author(s): 武田朱公、里直行、内尾-山田こずえ、楽木宏実、森下竜一
  • Organizer: 第29回日本認知症学会総会
  • Place of Presentation: 名古屋
• [Presentation] Fluvastatin (an HMG-CoA reductase inhibitor) reduces Abeta levels in brain by upregulating APP-CTFs degradation and Abeta clearance (2009)
  • Author(s): M. Shinohara, N. Sato, H. Kurinami, D. Takeuchi, S. Takeda, M. Noma, H. Rakugi, R
  • Organizer: Neuroscience
  • Place of Presentation: Chicago
  • Year and Date: 2009-10-18
• [Presentation] Fluvastatin (an HMG-CoA reductase inhibitor) reduces Abeta levels in brain by upregulating APP-CTFs degradation and Abeta clearance (2009)
  • Author(s): 篠原充, 里直行, 栗波仁美, 竹内大亮, 武田朱公, 野間基子, 楽木宏美, 森下竜一
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-18
• [Presentation] Possible mutual interaction between diabetes mellitus and Alzheimer's disease : Generation of novel transgenic mice models of Alzheimer's disease with diabetic conditions (2009)
  • Author(s): Shuko Takeda, Naoyuki Sato, Kozue Uchio-Yamada, Kyoko Sawada, Takanori Kunieda, Daisuke Takeuchi, Hitomi Kurinami, Mitsuru Shinohara, Hiromi Rakugi, Ryuichi Morishita
  • Organizer: ICAD (International Conference on Alzheimer's Disease) 2009
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2009-07-15
• [Presentation] 血糖状態及び血中インスリン値は血中Aβ量を修飾する : 血中Aβ値のアルツハイマー病バイオマーカーとしての最適化条件の検討 (2009)
  • Author(s): 武田朱公, 里直行, 内尾こずえ, 澤田京子, 國枝孝典, 篠原充, 栗波仁美, 竹内大亮, 楽木宏美, 森下竜一
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-19
• [Presentation] アルツハイマー病と糖尿病の相互的病態修飾機序の解明 : 新規病態合併モデル動物の作成とその解析 (2009)
  • Author(s): 武田朱公, 里直行, 内尾こずえ, 澤田京子, 國枝孝典, 栗波仁美, 竹内大亮, 篠原充, 楽木宏美, 森下竜一
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-18
• [Presentation] reduces Aβlevels in brain by upregulating APP-CTFs degradation and Aβ clearance. (2009)
  • Author(s): M.Shinohara, N.Sato, H.Kurinami, D.Takeuchi, S.Takeda, M.Noma, H.Rakugi, R.Morishita
  • Organizer: International Conference on Molecular Neurodegeneration
• [Presentation] The pharmacodynamic mechanisms of cognition enhancement by antihypertensive drugs (2009)
  • Author(s): 里直行
  • Organizer: IAGG world congress of GERONTOLOGY and GERIATRICS
  • Place of Presentation: Paris, France
• [Presentation] アルツハイマー病根本治療を目指したフルバスタチンの新規抗Aβ作用の解明 (2009)
  • Author(s): 篠原充, 里直行, 栗波仁美, 竹内大亮, 武田朱公, 野間基子, 楽木宏美, 森下竜一
  • Organizer: 第51回日本老年医学会学術集会
  • Place of Presentation: 横浜
• [Presentation] ATI受容体格抗薬は脳血管反応性を改善することでアルツハイマー病モデルマウスの認知機能を回復させる (2008)
  • Author(s): 武田朱公, 里 直行, 荻原俊男, 楽木宏実, 森下竜一
  • Organizer: 第12回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 熊本
  • Year and Date: 2008-11-29
• [Presentation] The protective effect of fluvastatin, a HMG-CoA reductase inhibitor, on the Aβ brain accumulation (2008)
  • Author(s): Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda s, Morishita R
  • Organizer: Neuroscience 2008, Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2008-11-16
• [Presentation] 脳血管作動性の改善を介したアルツハイマー病モデルマウスに対するATI受容体措抗薬による治療効果の検討 (2008)
  • Author(s): 武田朱公, 里 直行, 荻原俊男, 楽木宏実, 森下竜一
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-09
• [Presentation] 超音波を用いた肝細胞増殖因子遺伝子導入はマウスにおけるベーダ・アミロイド起因性認知機能を改善させる (2008)
  • Author(s): 竹内大亮, 里 直行, 栗波仁美, 楽木宏実, 荻原俊男, 森下竜一
  • Organizer: 第50回日本老年医学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2008-06-20
• [Presentation] Improvement of cognitive decline and cerebrovascular dysfunction in amouse model of Alzheimer disease with angiotensin receptor blocker, 01mesaratn (2008)
  • Author(s): Takeda s, Sato N, Rakugi H, Ogihara T, Morishita R
  • Organizer: 22^<nd> Scientific Meeting International Society of Hypertension
  • Place of Presentation: Berlin
  • Year and Date: 2008-06-17
• [Presentation] The protective effect of fluvastatin, an HMG-CoA reductase inhibitor, on the Aβ brain accumulation. (2008)
  • Author(s): M. Shinohara, N. Sato, H. Kurinami, D. Takeuchi, S. Takeda, F. Nakagami, R. Morishita
  • Organizer: Neuroscience
  • Place of Presentation: Washington DC
• [Remarks] ホームページ
  • URL: http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html
• [Remarks]
  • URL: http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html
• [Remarks]
  • URL: http://www.cgt.med.osaka-u.ac.jp/cont/norm04_c_4.html
• [Patent(Industrial Property Rights)] 透析プローブ (2010)
  • Inventor(s): 武田朱公、里直行、森下竜一、西野博仁、生村和子
  • Industrial Property Rights Holder: 大阪大学、株式会社エイコム
  • Acquisition Date: 2010-11-19
• [Patent(Industrial Property Rights)] アルツハイマー病の新規診断方法の発明 (2009)
  • Inventor(s): 武田朱公, 里直行, 内尾こずえ, 森下竜一
  • Industrial Property Rights Holder: 大阪大学, 医薬基盤研究所
  • Filing Date: 2009-02-13