Immuno-regulatory dysfunction in development of colitic dysplasia of patients with inflammatory bowel disease
| Project/Area Number |
20590751
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
MATSUMOTO Takayuki Hyogo College of Medicine, 医学部, 教授 (10209637)
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| Co-Investigator(Kenkyū-buntansha) |
IKEUCHI Hiroki 兵庫医科大学, 医学部, 教授 (80319863)
HIDA Nobuyuki 兵庫医科大学, 医学部, 講師 (40340963)
FUKUNAGA Ken 兵庫医科大学, 医学部, 講師 (80333540)
OHDA Yoshio 兵庫医科大学, 医学部, 助教 (10388811)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 潰瘍性大腸炎 / クローン病 / 炎症性発癌 / 粘膜免疫 / サーベイランス / 発癌 / 免疫監視機構 |
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| Research Abstract |
In the surveillance of colitic cancer in patients with long-standing inflammatory bowel disease, majority of the lesions were detectable under chromo-endoscopy, however, a part of flat lesions were not detectable. Photo-dynamic diagnosis (PDD) was useful to detect such lesions. Furthermore dysfunction in regulatory T cells and auto-reactive T cells were found in such long-standing cases, suggesting immune-regulatory dysfunction may play significant roles in the development of colitic neoplasia.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial2011
Author(s)
Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo S, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N,, Ueno F, Tanaka S, Watanabe M, Hibi T
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Journal Title
J Gastroenterol. 46巻(Suppl.1)
Pages: 11-16
NAID
Related Report
Peer Reviewed
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[Journal Article] Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis : a Japanese nationwide randomized controlled trial.2011
Author(s)
Watanabe T, Ajioka Y, Matsumoto T, Tomotsugu N, Takebayashi T, Inoue E, Iizuka B, Igarashi M, Iwao Y, Ohtsuka K, Kudo S, Kobayashi K, Sada M, Matsumoto T, Hirata I, Murakami K, Nagahori M, Watanabe K, Hida N, Ueno F, Tanaka S, Watanabe M, Hibi T.
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Journal Title
J Gastroenterol.
Volume: 46(Suppl.1)
Pages: 11-16
NAID
Related Report
Peer Reviewed
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[Journal Article] The expression profile of the functional regulatory T cells, CD4+CD25High+/FOXP3+, in patients with ulcerative colitis during active and quiescent disease.2009
Author(s)
Kamikozuru K, Fukunaga K, Hirota S, Hida N, Ohda Y, Yoshida K, Y Yokoyama, Tozawa K, Kawa K, Iimuro M, Nagase K, Saniabadi AR, Nakamura S, Miwa H, Matsumoto T
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Journal Title
Clin Exp Immnol 156巻
Pages: 320-327
Related Report
Peer Reviewed
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[Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis2008
Author(s)
Matsumoto T, Iwao Y, Igarashi M., Watanabe K, Otsuka K, Watanabe T, Iizuka B, Hida N, Sada M, Chiba T, Kudo S.E, Oshitani N, Nagawa H, Ajioka Y, Hibi T
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Journal Title
Inflamm. Bowel Dis. 14巻
Pages: 259-264
Related Report
Peer Reviewed
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[Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesions in surveillance colonoscopy for patients with long-standing ulcerative colitis.2008
Author(s)
Matsumoto, T., Iwao, Y., Igarashi, M., Watanabe, K., Otsuka, K., Watanabe, T., Iizuka, B., Hida, N., Sada, M., Chiba, T., Kudo, S. E., Oshitani, N., Nagawa, H., Ajioka, Y., Hibi, T.
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Journal Title
Inflamm. Bowel Dis. 14
Pages: 259-264
Related Report
Peer Reviewed
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[Journal Article] 多彩な病理形態を示したColitic Cancerの1例2008
Author(s)
内野基, 池内浩基, 松岡宏樹, 田中慶太, 久野隆史, 大嶋勉, 塚本潔, 中村光宏, 外賀真, 中埜廣樹, 野田雅史, 樋田信幸, 松本譽之, 竹末芳生, 冨田尚裕
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Journal Title
日本大腸肛門病学会誌 67
Pages: 267-271
NAID
Related Report
Peer Reviewed
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[Presentation] In patients with active ulcerative colitis, selective depletion of granulocytes and monocytes by extracorporeal adsorption impacts peripheral and mucosal level of CD4+ regulatory T-cells2008
Author(s)
Kamikozuru K, Fukunaga K, Hirota S, Yokoyama Y, Ohda Y, Hida N, Nakamura S, Miwa H, Matsumoto, T
Organizer
The 16th United European Gastroenterology Week (UEGW2008)
Place of Presentation
ウィーン(オーストリア)
Year and Date
2008-10-22
Related Report
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[Presentation] In patients with active ulcerative colitis, selective depletion of granulocytes and monocytes by extracorporeal adsorption impacts peripheral and mucosal level of CD4+ regulatory T-cells.2008
Author(s)
Kamikozuru, K., Fukunaga, K., Hirota, S., Yokoyama, Y., Ohda, Y., Hida, N., Nakamura, S., Miwa, H., Matsumoto, T.
Organizer
The 16th United European Gastroenterology Week (UEGW2008)
Place of Presentation
ウィーン(オーストリア)
Year and Date
2008-10-22
Related Report
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[Presentation] Demonstration of low CD25 high+CD4+ and highCD28-CD4+ T-cell subsets in patients with ulcerative colitis.2008
Author(s)
Yokoyama, Y., Fukunaga, K., Kamikozuru, K., Nakmaura, S., Miwa, H., Matsumoto, T.
Organizer
The 16th United European Gastroenterology Week (UEGW2008)
Place of Presentation
ウィーン(オーストリア)
Year and Date
2008-10-22
Related Report
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[Presentation] The Expression of CD25highCD4+ T-cells and CD28-CD4+ T-cells in ulcerative colitis2008
Author(s)
Yokoyama Y, Fukunaga K, Ikeuchi H, Kamikozuru K, Tozawa K, Uchino M, Yoshida K, Hida N, Nakamura S, Miwa H, Matsumoto T
Organizer
The 3rd Japan-Korea IBD symposium
Place of Presentation
ソウル(大韓民国)
Year and Date
2008-09-20
Related Report
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[Presentation] The Expression of CD25highCD4+ T-cells and CD28-CD4+ T-cells in ulcerative colitis.2008
Author(s)
Yokoyama, Y., Fukunaga, K., Ikeuchi, H., Kamikozuru, K., Tozawa, K., Uchino, M., Yoshida, K., Hida, N., Nakamura, S., Miwa, H., Matsumoto, T.
Organizer
The 3^<rd> Japan-Korea IBD symposium
Place of Presentation
ソウル(大韓民国)
Year and Date
2008-09-20
Related Report
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