| Project/Area Number |
20590754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKUTA Katsuya 旭川医科大学, 医学部, 講師 (00396376)
SASAKI Katsunori 旭川医科大学, 医学部, 特任准教授 (60336394)
SATOU Kazuya 旭川医科大学, 医学部, 講師 (50360988)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 非アルコール性脂肪性肝疾患 / アルコール性肝障害 / トランスフェリン受容体 / ヘプシジン / 鉄トランスポーター / 非トランスフェリン結合鉄 / 非アルコール性脂肪性肝炎 |
|---|
| Research Abstract |
Excess iron is frequently accumulated in chronic liver diseases. The pathogenesis and iron metabolism abnormality are overlapped, which may be progressed by the interaction. Non-alcoholic fatty liver disease (NAFLD) also frequently merges with secondary hepatic iron accumulation, which contributes to the development of oxidative stress, liver cell damage, fibrosis and carcinogenesis. In this study, we investigated the expression of iron-related molecules in liver and duodenum tissue in mice fatty liver model and human hepatocellular in vitro model. Obesity and high-fat diet up-regulate TfR1 expression and down-regulate Hepc expression in the liver. Furthermore they up-regulate the iron transporter expressions in the duodenum.
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