| Project/Area Number |
20590824
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJITA Masatoshi Kyoto University, 大学院・医学研究科, 教授 (50190046)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Tetsuya 滋賀医科大学, 医学部, 講師 (70273406)
MIYAMOTO Shoichi (財)田附興風会, 心臓センター, 副部長 (30435557)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 加速ベッド / 動脈硬化 / 狭心症 / 糖尿病 / 血管内皮機能 / 運動耐容能 / 血管内皮前駆細胞 / Endo-PAT / 心不全 / 心筋シンチグラフィ / トレッドミル負荷試験 |
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| Research Abstract |
The whole-body periodic acceleration (WBPA) bed has recently been developed as a "passive exercise" device by providing increased pulsatile shear stress for improvement of vascular endothelial function. In the present study, we evaluated the effects of the WBPA treatment on exercise tolerance in patients with chronic stable angina, coronary flow reserve in healthy subjects and patients with coronary artery disease, and vascular endothelial function in type 2 diabetic patients. In angina patients, 20 sessions of the WBPA treatment improved the treadmill exercise tolerance, myocardial perfusion at rest and during adenosine infusion, and left ventricular remodeling. Only one session of the WBPA treatment ameliorated coronary flow reserve in patients with coronary artery disease as well as in normal subjects. In type 2 diabetic patients, the impaired vascular endothelial function was augmented by 10 sessions of the WBPA treatment, and the improvement was associated with the increase in the number of endothelial progenitor cells. These promising results of the WBPA treatment provide a possibility that the treatment will be a novel therapeutic strategy for a variety of cardiovascular diseases.
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