• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of new treatment for atherosclerosis by regulating cell-mediated immunity

Research Project

Project/Area Number 20590880
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISOBE Mitsuaki  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (80176263)

Co-Investigator(Kenkyū-buntansha) SUZUKI Juniichi  東京医科歯科大学 (90313858)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords動脈硬化 / 心臓移植 / 冠動脈再狭窄 / 細胞性免疫 / トランスジェニックマウス / 移植心冠動脈硬化 / アディポネクチン / アディポサイトカイン / 内膜肥厚 / 炎症 / ICAM-1 / 遺伝子導入 / 超音波 / マイクロバブル / 血管障害 / 再狭窄 / 接着分子 / 炎症抑制 / クラリスロマイシン / 拒絶反応 / 血管狭窄 / MMP-9 / サイトカイン / 平滑筋細胞 / 慢性拒絶
Research Abstract

We investigated the role of cell-mediated immunity on the mechanism of arterioscelrosis using mouse models of cardiac allograft transplantation and wire-induced injury of the femoral artery. We paid attention to MMP-9, ICAM-1, and adiponectin as mediators or suppressors of arteriosclerosis in these models. Clarithromycin which suppresses MMP-9 activity and siRNA ICAM-1 were effective in suppressing arterial lesions and adiponectin over expression mouse showed lesser extent of chronic allograft rejection. These results indicate the role of immunity and inflammation on the arterioscelrosis and these new agents may be useful as new targets for prevention of clinical diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 7 results) Presentation (2 results) Book (4 results)

  • [Journal Article] The effects of pharmacological plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts.2011

    • Author(s)
      Ogawa M, Suzuki J, Yamaguchi Y, Muto S, Itai A, Hirata Y, Isobe M, Nagai R.
    • Journal Title

      Transplantation. 91(1)

      Pages: 21-26

    • Related Report
      2010 Final Research Report
  • [Journal Article] The effects of pharmacological plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts.2011

    • Author(s)
      Ogawa M, Suzuki J, Yamaguchi Y, Muto S, Itai A, Hirata Y, Isobe M, Nagai R
    • Journal Title

      Transplantation

      Volume: 91 Pages: 22-26

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of adiponectin on the cardiac allograft vasculopathy2011

    • Author(s)
      Ishihara T, Haraguchi G, Konishi M, Ohigashi H, Saito K, Nakano Y, Isobe M
    • Journal Title

      Circulation Journal

      Volume: 印刷中

    • NAID

      10029128354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrasound-Microbubble Mediated ICAM-1 siRNA Transfection Attenuates Neointimal Formation after Arterial Injury in Mice.2010

    • Author(s)
      Suzuki J, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M
    • Journal Title

      J Am Coll Cardiol 55

      Pages: 904-913

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Inhibition of endostatin deterioratesleft ventricular remodeling and heart failure through matrix proteinases and angiotensin converting enzyme in rat myocardial infarction.2010

    • Author(s)
      Isobe K, Kuba K, Maejima Y, Suzuki J, Kubota S, Isobe M
    • Journal Title

      Circ J 74(1)

      Pages: 109-119

    • Related Report
      2010 Final Research Report
  • [Journal Article] Treatment with telmisartan attenuates graft arterioscelrosis in murine cardiac allografts.2010

    • Author(s)
      Kosuge H, Ishihara T, Haraguchi G, Maejima Y, Okada H, Saiki H, Suzuki H, Isobe M
    • Journal Title

      J Heart Lung Transplant 29(Jan)

      Pages: 562-567

    • Related Report
      2010 Final Research Report
  • [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.2010

    • Author(s)
      Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia C-p, Keene AC, Alayari NN, Elling U, Berger C, Novatchkova M, Koglgruber R, Nishina H, Isobe M, Pospisilik JA, Imai Y, Knoblich JA, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Bodmer R, Penninger JM
    • Journal Title

      Cell 41

      Pages: 1-12

    • Related Report
      2010 Final Research Report
  • [Journal Article] Treatment with telmisartan attenuates graft arterioscelrosis in murine cardiac allografts.2010

    • Author(s)
      Kosuge H, Ishihara T, Haraguchi G, Maejima Y, Okada H, Saiki H, Suzuki H, Isobe M
    • Journal Title

      J Heart Lung Transplant

      Volume: 29 Pages: 562-567

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase suppression induced by clarithromycin in murine cardiac allografts.2009

    • Author(s)
      Ogawa M, Suzuki J, Takayama K, Isobe M.
    • Journal Title

      Transplant Proc. 41

      Pages: 395-397

    • Related Report
      2010 Final Research Report
  • [Journal Article] An initial case of suppressed restenosis with nuclear factor-kappa B decoy transfection after percutaneous coronary intervention.2009

    • Author(s)
      Suzuki J, Tezuka D, Morishita R, Isobe M
    • Journal Title

      J Gene Med 11

      Pages: 89-91

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] The Mechanism of Anti-Inflammatory Effects of Prostaglandin E2 Receptor 4 Activation in Murine Cardiac Transplantation.2009

    • Author(s)
      Ogawa M, Suzuki J, Isobe M
    • Journal Title

      Transplantation 87

      Pages: 1645-1653

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] A critical role of COX-2 in the progression of neointimal formation after wire injury in mice.2009

    • Author(s)
      Ogawa M, Suzuki J, Hirata Y, Nagai R, Isobe M.
    • Journal Title

      Expert Opin Ther Targets. 13

      Pages: 505-511

    • Related Report
      2010 Final Research Report
  • [Journal Article] A critical role of COX-2 in the progression of neointimal formation after wire injury in mice.2009

    • Author(s)
      Ogawa M, Suzuki J, Hirata Y, Nagai R, Isobe M
    • Journal Title

      Expert Opin Ther Targets 13

      Pages: 505-511

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway.2009

    • Author(s)
      Haga T, Suzuki J, Kosuge H, Ogawa M, Saiki H, Haraguchi G, Maejima Y, *Isobe M, Uede T
    • Journal Title

      J Mol Cell Cardiol 46

      Pages: 717-727

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clarithromycin Attenuates Acute and Chronic Rejection via MMP Suppression in Murine Cardiac Transplantation.2008

    • Author(s)
      Ogawa M, Suzuki J, Isobe M
    • Journal Title

      J Am Coll Cardiol 51

      Pages: 1977-1985

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts.2008

    • Author(s)
      Saiki H, Suzuki J, Kosuge H, Haraguchi G, Ishihara T, Haga T, Maejima Y, Isobe M, Uede T
    • Journal Title

      Int Heart J 49

      Pages: 105-118

    • NAID

      130000068976

    • Related Report
      2010 Final Research Report
  • [Journal Article] Long-term follow up of initial clinical cases with NF-kB decoy oligodeoxynucleotide transfecton at the site of coronary stenting.2008

    • Author(s)
      Egashira K, Suzuki J, Ito H, Aoki M, Isobe M, Morishita R
    • Journal Title

      J Gene Med 10

      Pages: 805-809

    • Related Report
      2010 Final Research Report
  • [Journal Article] The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury.2008

    • Author(s)
      Suzuki J, Ogawa M, Muto S, Yamaguchi Y, Itai A, Isobe M
    • Journal Title

      Expert Opin Ther Targets 12

      Pages: 783-794

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] Suppression of neointimal hyperplasia after vascular injury by blocking 4-1BB/4-1BB ligand pathway.2008

    • Author(s)
      Karube A, Suzuki J, Haraguchi G, Maejima Y, Saiki H, Kosuge H, Isobe M, Uede T
    • Journal Title

      J Med Dent Sci 55

      Pages: 207-213

    • NAID

      110006827395

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clarithromycin Attenuates Acute and Chronic Rejection via MMP Suppression in Murine Cardiac Transplantation.2008

    • Author(s)
      Ogawa M, Suzuki J, IsobeM
    • Journal Title

      J Am Coll Cardiol 51

      Pages: 1977-1985

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adioponectin protects doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK upregulation in mice.

    • Author(s)
      Konishi M, Haraguchi G, Ishihara T, Ohgashi H, Saito K, Nakano Y, Isobe M
    • Journal Title

      Cardiovasc Res in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] Porphyromonas gingivalis Promotes Murine Abdominal Aortic Aneurysms via Matrix Metalloproteinase-2 Induction.

    • Author(s)
      Aoyama N, J Suzuki J, Wang D, Ogawa M, Kobayashi N, Hanatani T, Takeuchi Y, Izumi Y, Isobe M
    • Journal Title

      J Period Res in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] The effect of adiponectin on the cardiac allograft vasculopathy.

    • Author(s)
      Ishihara T, Haraguchi G, Konishi M, Ohigashi H, Saito K, Nakano Y, Isobe M
    • Journal Title

      Circ J in press

    • NAID

      10029128354

    • Related Report
      2010 Final Research Report
  • [Journal Article] The Mechanism of Anti-Inflammatory Effects of Prostaglandin E2 Receptor 4 Activation in Murine Cardiac Transplantation.

    • Author(s)
      Ogawa M, Suzuki J, IsobeM
    • Journal Title

      Transplantation (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Role of Plasminogen Activator Inhibitor-1 on the Prevention of Acute and Chronic Rejection in Murine Cardiac Allografts.2010

    • Author(s)
      Suzuki JI, Ogawa M, Isobe M
    • Organizer
      XXIII International Congress of The Transplantation Society
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effects of pharmacological PAI-1 inhibition in acute and chronic rejection in murine cardiac allografts2009

    • Author(s)
      Suzuki J, Isobe M
    • Organizer
      merican Heart Association Scientific Meeting 2009
    • Place of Presentation
      Orland
    • Related Report
      2009 Annual Research Report
  • [Book] Gene therapy for prevention of acute and chronic cardiac rejection. Heart Transplantation.2010

    • Author(s)
      Suzuki J, Isobe M, Morishita R, Nagai R
    • Publisher
      NOVA Science Publishers
    • Related Report
      2010 Annual Research Report
  • [Book] Anti-Oxidation on Cardiovascular Diseases.

    • Author(s)
      Suzuki J, Isobe M, Morishita R, Nagai R
    • Publisher
      Springer/Humana Press. California(in press)
    • Related Report
      2009 Annual Research Report
  • [Book] Roles of Prostaglandin E2 and its Receptors in Inflammation-Related Cardiovascular Diseases.

    • Author(s)
      Suzuki J, Ogawa M, Hishikari K, Takayama K, Isobe M
    • Publisher
      NovaScience(in press)
    • Related Report
      2009 Annual Research Report
  • [Book] Roles of Prostaglandins and the Receptors in the Development of Myocardial Ischemia

    • Author(s)
      Hishikari K, Suzuki J, Ogawa M, Isobe M
    • Publisher
      Nova Science(in press)
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi