| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Apoptogenic Protein (Apop) was originally identified in the atherosclerotic plaques of model animals. Apop gene expression was also identified in human atherosclerosis in carotid arteries. Proliferative smooth muscle cells, which contribute to the formation of atherosclerosis, expressed Apop, while contractile smooth muscle cells in normal arteries did not. These findings indicate the implication of Apop in the development of atherosclerosis. Moreover, Apop deficient mouse was generated in this study to reveal the function of Apop gene in vivo.
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