The effect of aging and smoking on the phagocytosis of apoptotic cells in alveolar macrophages

• Project/Area Number: 20590890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: NASUHARA Yasuyuki Hokkaido University, 病院, 准教授 (30322811)
• Co-Investigator(Kenkyū-buntansha): ITO Yoko 北海道大学, 病院, 助教 (90286451) ; BETSUYAKU Tomoko 北海道大学, 大学院・医学研究科, 准教授 (60333605)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 閉塞性肺疾患 / マクロファージ / 喫煙 / アポトーシス / 炎症 / マクロフィージ

Research Abstract

Our aims of this study are to examine expressions of various receptors for recognition and/or clearance of apoptotic cells on macrophages and assess the relationship with aging and/or smoking. The expression of phosphatidylserine receptor (PSR) and scavenger receptor A (SR-A) in alveolar macrophages was downregulated in smokers when compared to lifelong non-smokers only in the older subjects, but not in younger subjects. The expression of PSR is elevated on U937-derived macrophage like cells if these are incubated in CSE. The cigarette smoke extract-induced upregulation of PSR was inhibited by the vascular endothelial growth factor (VEGF) receptor blockade, SU5614, in U937-derived macrophage-like cells. These results showed that VEGF was indirectly associated with the ability to phagocytose apoptotic cells through the expression of PSR.

Research Products

• [Journal Article] The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema. (2011)
  • Author(s): Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.
  • Journal Title: Am J Respir Crit Care Med. 183 Pages: 876-884
  • Peer Reviewed
• [Journal Article] The role of catalase in pulmonary fibrosis. (2011)
  • Author(s): Odajima N, Betsuyaku T, Nagai K, Moriyama C, Wang DH, Takigawa T, Ogino K, Nishimura M.
  • Journal Title: Respiratory Research. 11 Pages: 183-183
  • Peer Reviewed
• [Journal Article] The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema. (2011)
  • Author(s): Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM.
  • Journal Title: Am J Respir Crit Care Med. Volume: 183 Pages: 876-884
  • Peer Reviewed
• [Journal Article] High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis. (2010)
  • Author(s): Odajima N, Betsuyaku T, Yoshida T, Hosokawa T, Nishimura M.
  • Journal Title: Hum Pathol. 41 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts. (2010)
  • Author(s): Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA.
  • Journal Title: Am J Respir Cell Mol Biol. 43 Pages: 576-584
  • Peer Reviewed
• [Journal Article] Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics. (2010)
  • Author(s): Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M.
  • Journal Title: Respir Med. 104 Pages: 1809-1816
  • NAID: 120002678124
  • Peer Reviewed
• [Journal Article] Levels of transferrin in bronchoalv eolar lavage fluid in sarcoidosis. (2010)
  • Author(s): Shigemura M, Nasuhara Y, Konno S, Hattori T, Shimizu C, Matsuno K, Nishimura M.
  • Journal Title: Lung. 188 Pages: 151-157
  • NAID: 120002834677
  • Peer Reviewed
• [Journal Article] Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines. (2010)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M.
  • Journal Title: Am J Respir Cell Mol Biol. 42 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastaseand cigarette smoke-induced pulmonary emphysema in mice. (2010)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. 296
  • Peer Reviewed
• [Journal Article] The role of catalase in pulmonary fibrosis. (2010)
  • Author(s): Odajima N, Betsuyaku T, Nagai K, Moriyama C, Wang DH, Takigawa T, Ogino K, Nishimura M.
  • Journal Title: Respiratory Research Volume: 11
  • Peer Reviewed
• [Journal Article] 喘息として加療されフローボリューム曲線が発見の契機となった成人重複大動脈弓の1例 (2010)
  • Author(s): 吉田貴之, 今野哲, 高橋歩, 南須原康行, 別役智子, 西村正治
  • Journal Title: 日本呼吸器学会雑誌 Volume: 48 Pages: 229-234
  • NAID: 10026930665
  • Peer Reviewed
• [Journal Article] High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis. (2010)
  • Author(s): Odajima N, Betsuyaku T, Yoshida T, Hosokawa T, Nishimura M.
  • Journal Title: Hum Pathol. Volume: 41 Pages: 935-943
  • Peer Reviewed
• [Journal Article] Cigarette smoke induces nucleic-acid oxidation in lung fibroblasts. (2010)
  • Author(s): Deslee G, Adair-Kirk TL, Betsuyaku T, Woods JC, Moore CH, Gierada DS, Conradi SH, Atkinson JJ, Toennies HM, Battaile JT, Kobayashi DK, Patterson GA, Holtzman MJ, Pierce RA.
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 43 Pages: 576-584
  • Peer Reviewed
• [Journal Article] A case of follicular bronchiolitis associated with asthma, eosinophilia, and increased immunoglobulin E. (2010)
  • Author(s): Shimizu K, Konno S, Nasuhara Y, Tanino M, Matsuno Y, Nishimura M.
  • Journal Title: J Asthma Volume: 47 Pages: 1161-1164
  • NAID: 120003537884
  • Peer Reviewed
• [Journal Article] Airflow limitation and airway dimensions assessed perbronchial generation in older asthmatics. (2010)
  • Author(s): Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M.
  • Journal Title: Respir Med. Volume: 104 Pages: 1809-1816
  • Peer Reviewed
• [Journal Article] Endobronchial actinomycosis associated with a foreign body--successful short-term treatment with antibiotics--. (2010)
  • Author(s): Maki K, Shinagawa N, Nasuhara Y, Oizumi S, Domen H, Haga H, Nishimura M.
  • Journal Title: Intern Med. Volume: 49 Pages: 1293-1296
  • NAID: 130000299527
  • Peer Reviewed
• [Journal Article] Inhaled Granulocyte/Macrophage-Colony Stimulating Factor as Therapy of Pulmonary Alveolar Proteinosis (2010)
  • Author(s): Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K
  • Journal Title: Am J Respir Crit Care Med (in press)
  • Peer Reviewed
• [Journal Article] Levels of transferrin in bronchoalveolar lavage fluid in sarcoidosis (2010)
  • Author(s): Shigemura M, Nasuhara Y, Konno S, Hattori T, Shimizu C, Matsuno K, Nishimura M
  • Journal Title: Lung 188 Pages: 151-157
  • NAID: 120002834677
  • Peer Reviewed
• [Journal Article] Aging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokines (2010)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Journal Title: Am J Respir Cell Mol Biol 42 Pages: 304-311
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages. (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M.
  • Journal Title: Biogerontology. 10 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM. (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M.
  • Journal Title: Respir Med. 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Relationship between improvedairflow limitation and changes in airway caliber induced by inhaled anticholinergic agents in COPD. (2009)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T,Nishimura M.
  • Journal Title: Thorax 64 Pages: 332-338
  • Peer Reviewed
• [Journal Article] 胸痛を呈し、胸膜病変の診断と病勢評価にFDG-PET(fluorodeoxyglucose-positron emission tomography)が有用であったサルコイドーシスの1例 (2009)
  • Author(s): 服部健史, 今野哲, 猪又崇志, 南須原康行, 別役智子, 西村正治
  • Journal Title: 日本呼吸器学会雑誌 47 Pages: 658-662
  • NAID: 10027676759
  • Peer Reviewed
• [Journal Article] Comparison of the pharmacodynamics of biapenem in bronchial epithelial lining fluid in healthy volunteers given half-hour and three-hour intravenous infusions (2009)
  • Author(s): Kikuchi E, Kikuchi J, Nasuhara Y, Oizumi S, Ishizaka A, Nishimura M
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 2799-2803
  • NAID: 120001415113
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice (2009)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol 296
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Biogerontology 10 Pages: 173-180
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinases in blood from patients with LAM (2009)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M
  • Journal Title: Respir Med 103 Pages: 124-129
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergic agents in COPD (2009)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
  • Journal Title: Thorax 64 Pages: 332-338
  • Peer Reviewed
• [Journal Article] Curcumin attenuates elastase-and cigarette smoke-induced pulmonary emphysema in mice (2009)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Odajima N, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Am J Phvsiol Lung Cell Mol Phvsiol 296(4)
  • Peer Reviewed
• [Journal Article] Relationship between improved airflow limitation and changes in airway calibre induced by inhaled anticholinergic agents in COPD (2009)
  • Author(s): Hasegawa M, Makita H, Nasuhara Y, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
  • Journal Title: Thorax 64(4) Pages: 332-338
  • Peer Reviewed
• [Journal Article] Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages (2009)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Journal Title: Biogerontology 10(2) Pages: 173-180
  • Peer Reviewed
• [Journal Article] Distal airways in mice exposed to cigarette smoke : Nrf2-regulated genes are increased in Clara cells (2008)
  • Author(s): Adair-Kirk TL, Atkinson JJ, Griffin GL, Watson MA, Kelley DG, DeMello D, Senior RM, Betsuyaku T.
  • Journal Title: Am J Respir Cell Mol Biol 39 Pages: 400-411
  • Peer Reviewed
• [Journal Article] Bronchiolar chemokine expression is different after single versus repeated cigarette smoke exposure (2008)
  • Author(s): Betsuyaku T, Hamamura I, Hata J, Takahashi H, Mitsuhashi H, Adair-Kirk TL, Senior RM, Nishimura M.
  • Journal Title: Respir Res 9 Pages: 7-7
  • Peer Reviewed
• [Journal Article] the Hokkaido COPD Cohort Study Group.:"Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients" (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M
  • Journal Title: Eur Respir J. 32(2) Pages: 372-378
  • Peer Reviewed
• [Journal Article] Role of basement membrane in EMM PRIN/CD147 induction in rat tracheal epithelial cells (2008)
  • Author(s): Hosokawa T, Betsuyaku T, Odajima N, Suzuki M, Mochitate K, Nasuhara Y, Nishimura M.
  • Journal Title: Biochem Biophys Res Commun 368(2) Pages: 426-432
  • Peer Reviewed
• [Journal Article] Dual oxidase 1 and 2 expression in airwayepithelium of smokers and patients with mild/moderate chronic obstructive pulmonary disease (2008)
  • Author(s): Nagai K, Betsuyaku T, Suzuki M, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Journal Title: Antioxid Redox Signal 10(4) Pages: 705-714
  • Peer Reviewed
• [Journal Article] Diversity of protein carbonylation in allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M.
  • Journal Title: Free Radic Res 42(11-12) Pages: 921-929
  • Peer Reviewed
• [Journal Article] Decreased airway expression of vascular endothelial growth factor in cigarette smoke-induced emphysema in mice and COPD patients (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nagai K, Fuke S, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Hata J, Takahashi H, Nishimura M.
  • Journal Title: Inhal Toxicol 20(3) Pages: 349-3
  • Peer Reviewed
• [Journal Article] Down-Regulated NF-E2-Related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M.
  • Journal Title: Am J Respir Cell Mol Biol 39(6) Pages: 673-682
  • Peer Reviewed
• [Journal Article] Diversity of protein carbonylation in allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Journal Title: Free Radic Res 42(11-12) Pages: 921-929
  • Peer Reviewed
• [Journal Article] Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease (2008)
  • Author(s): Suzuki M, Betsuyaku T, Ito Y, Nagai K, Nasuhara Y, Kaga K, Kondo S, Nishimura M
  • Journal Title: Am J Respir Cell Mol Biol 39(6) Pages: 673-682
  • Peer Reviewed
• [Journal Article] Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients (2008)
  • Author(s): Hizawa N, Makita H, Nasuhara Y, Hasegawa M, Nagai K, Ito Y, Betsuyaku T, Konno S, Nishimura M ; Hokkaido COPD Cohort Study Groun
  • Journal Title: Eur Respir J 32(2) Pages: 372-378
  • Peer Reviewed
• [Presentation] 国立大学付属病院医療安全管理協議会 医師GRMアンケート結果 (2010)
  • Author(s): 南須原康行
  • Organizer: 第5回医療の質・安全学会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2010-11-27
• [Presentation] Glycan X, a keratan sulfate oligosaccharide, attenuates elastase-induced lung inflammation and emphysema in mice. (2010)
  • Author(s): Yoshida T, Gao C, Betsuyaku T, Ota F, Matsumoto A, Nishimura M, Taniguchi N
  • Organizer: The 106^<th> American Thoracic Society International Conference.
  • Place of Presentation: New Orleans USA.
  • Year and Date: 2010-06-17
• [Presentation] Glycan X, a keratan sulfate oligosaccharide, attenuates elastase-induced lung inflammation and emphysema in mice (2010)
  • Author(s): Yoshida T, Gao C, Betsuyaku T, Ota F, Matsumoto A, Nishimura M, Taniguchi N
  • Organizer: The 106^<th> American Thoracic Society International Conference
  • Place of Presentation: New Orleans USA
  • Year and Date: 2010-05-17
• [Presentation] Aging affects the airway expression of Nrf2 in response to cigarette smoke. (2010)
  • Author(s): Nagai K, Betsuyaku T, Nishimura M
  • Organizer: The 106th American Thoracic Society International Conference.
  • Place of Presentation: New Orleans, USA.
  • Year and Date: 2010-05-15
• [Presentation] Aging affects the airway expression of Nrf2 in response to cigarette smoke (2010)
  • Author(s): Nagai K, Betsuyaku T, Nishimura M
  • Organizer: The 106^<th> American Thoracic Society International Conference
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-05-15
• [Presentation] Comparison of airway. remodelling assessed by three-dimensional CT between Bronchial Asthma and chronic obstructive pulmonary disease (2010)
  • Author(s): Shimizu K, Hasegawa M, Makita H, Nasuhara Y, Konno S, Nishimura M
  • Organizer: The 106^<th> American Thoracic Society International Conference
  • Place of Presentation: New Orleans USA
  • Year and Date: 2010-05-15
• [Presentation] 臨床安定期の中・高年気管支喘息患者における肺CT3次元気道解析でみた気道病変と気流閉塞との関係 (2010)
  • Author(s): 清水薫子, 長谷川大, 牧田比呂仁, 南須原康行, 今野哲, 西村正治
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] 加齢、短期間喫煙曝露、その後の禁煙が細気管支上皮におけるmicro RNA (miRNA)プロファイルに及ぼす影響 (2010)
  • Author(s): 守山千夏, 別役智子, 西村正治
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] MMP活性阻害能を有するグリコサミノグリカン(Glycan X)のエラスターゼ誘導マウス肺気腫モデルにおける抗炎症および気腫形成抑制効果の検討 (2010)
  • Author(s): 吉田貴之, 高叢笑, 別役智子, 太田芙美, 松本明郎, 西村正治, 谷口直之
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] アレルギー性気道炎症モデルにおけるDHMEQの効果 (2010)
  • Author(s): 清水健一, 今野哲, 清水薫子, 谷口菜津子, 伊佐田朗, 高橋歩, 服部健史, 梅澤一夫, 尾崎倫孝, 藤堂省, 西村正治
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] 加齢、短期間喫煙曝露、その後の禁煙が細気管支上皮におけるmicro RNA(miRNA)プロファイルに及ぼす影響 (2010)
  • Author(s): 守山千夏, 別役智子, 西村正治
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] COPD患者の1秒量の再現性に与える因子に関する検討 (2010)
  • Author(s): 山本雅史, 今野哲, 南須原康行, 牧田比呂仁, 西村正治
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-25
• [Presentation] 呼吸器疾患のリスクマネジメント (2010)
  • Author(s): 南須原康行
  • Organizer: 第50回日本呼吸器学会学術講演会教育講演10
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-24
• [Presentation] 呼吸器疾患のリスクマネジメント (2010)
  • Author(s): 南須原康行
  • Organizer: 第50回日本呼吸器学会学術講演会 教育講演10
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-24
• [Presentation] The role of catalase in cigarette smoke(CS) -induced pulmonary inflammation and emphysema in murine model. (2010)
  • Author(s): Inomata T, Betsuyaku T, Odajima N, Nagai K, Yoshida T, Moriyama C, Maki K, Nishimura M
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] Association of β2-adrenoreseptor genotype with bronchodilator responses (BDR) in COPD. (2010)
  • Author(s): Konno S, Makita H, Hasegawa M, Shimizu K, Taniguchi N, Nasuhara Y, Betsuyaku T, Nishimura M
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] 呼吸器内科医を目指す女性医師のキャリアパスならびにキャリア支援 (2010)
  • Author(s): 駒瀬裕子, 別役智子
  • Organizer: 第50回日本呼吸器学会学術講演会 シンポジウム6 呼吸器科医をいかに育成するか
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] 若い喫煙者にこそ、積極的な禁煙治療を (2010)
  • Author(s): 別役智子
  • Organizer: 第50回日本呼吸器学会学術講演会 ランチョンセミナー6
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] The role of catalase in cigarette smoke (CS)-induced pulmonary inflammation and emphysema in murine model (2010)
  • Author(s): Inomata T, Betsuyaku T, Odajima N, Nagai K, Yoshida T, Moriyama C, Maki K, Nishimura M
  • Organizer: 第50回日本呼吸器学会学術講演会English mini symposium
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] Association of β2-adrenoreseptor genotype with bronchodilator responses (BDR) in COPD (2010)
  • Author(s): Konno S, Makita H, Hasegawa M, Shimizu K, Taniguchi N, Nasuhara Y, Betsuyaku T, Nishimura M
  • Organizer: 第50回日本呼吸器学会学術講演会English mini symposium
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-04-23
• [Presentation] 慢性閉塞性肺疾患(COPD)の自然歴に関する研究-北海道COPDコホート研究4年後の追跡調査- (2010)
  • Author(s): 牧田比呂仁, 長井桂, 南須原康行, 長谷川大, 守山千夏, 別役智子, 西村正治
  • Organizer: 第107回日本内科学会総会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-04-09
• [Presentation] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease. (2009)
  • Author(s): Hasegawa M, Nasuhara Y, akita H, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-14
• [Presentation] Relationship between improved airflow limitation and changes in airway caliber induced by inhaled anticholinergics in chronic obstructive pulmonary disease (2009)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Odajima N, Nagai K, Ito Y, Betsuyaku T, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-14
• [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid (BALF) in lipopolysaccaride (LPS) induced lung injury. (2009)
  • Author(s): Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-13
• [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients. (2009)
  • Author(s): Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-13
• [Presentation] アレルギー性気道炎症モデルにおける気道被覆液中のグルタチオン化蛋白の検討 (2009)
  • Author(s): 長井桂, 別役智子, 南須原康行, 近藤宇史, 西村正治
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-13
• [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid(BALF)in lipopolysaccaride(LPS)induced lung injury (2009)
  • Author(s): Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-13
• [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2009)
  • Author(s): Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: 第49回日本呼吸器学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-06-13
• [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease (COPD) patients. (2009)
  • Author(s): Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference.
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States.
  • Year and Date: 2009-05-17
• [Presentation] Protein S-glutathionylation in the Epithelial Lining Fluid during Allergic Airway Inflammation. (2009)
  • Author(s): Nagai K, Betsuyaku T, Nasuhara Y, Kondo T, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference.
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States.
  • Year and Date: 2009-05-17
• [Presentation] Duration of cigarette smoke (CS) exposure affects the resolution of lung inflammation after cessation in mice. (2009)
  • Author(s): Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States.
  • Year and Date: 2009-05-17
• [Presentation] Kinetics of various ocidative stress markers in bronchoalveolar lavage fluid (BALF) in lipopolysaccaride (LPS) induced lung injury. (2009)
  • Author(s): Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States.
  • Year and Date: 2009-05-17
• [Presentation] Catalase expression in pulmonary macrophages of smokers and chronic obstructive pulmonary disease(COPD)patients (2009)
  • Author(s): Inomata T, Betsuyaku T, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States
  • Year and Date: 2009-05-17
• [Presentation] Protein S-glutathionylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2009)
  • Author(s): Nagai K, Betsuyaku T, Nasuhara Y, Kondo T, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States
  • Year and Date: 2009-05-17
• [Presentation] Duration of cigarette smoke(CS)exposure affects the resolution of lung inflammation after cessation in mice (2009)
  • Author(s): Odajima N, Betsuyaku T, Inomata T, Yoshida T, Moriyama C, Suzuki K, Nagai K, Nasuhara Y, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States
  • Year and Date: 2009-05-17
• [Presentation] Kinetics of various oxidative stress markers in BAL fluid in lipopolysaccaride(LPS)-induced lung injury (2009)
  • Author(s): Yoshida T, Betsuyaku T, Nagai K, Ito Y, Nasuhara Y, Nishimura M
  • Organizer: The 105^<th> American Thoracic Society International Conference
  • Place of Presentation: The San Diego Convention Center, San Diego, CA, United States
  • Year and Date: 2009-05-17
• [Presentation] Hokkaido COPD Cohort Study Group : Annual decline in forced expiratory volume in 1 sec (FEV1) in patients with COPD before and after introduction of tiotropium (2008)
  • Author(s): Fuke S, Makita H, Hasegawa M, Nasuhara Y, Betsuyaku T, Nishimura M
  • Organizer: European Respiratory Society AnnualCongress 2008
  • Place of Presentation: Berlin Germany
  • Year and Date: 2008-10-07
• [Presentation] The Hokkaido COPD Cohort Study Group : Body mass index is an independent risk factor for exacerbation in patients with COPD (2008)
  • Author(s): Nasuhara Y, Makita H, Nagai K, Betsuyaku T, Nishimura M
  • Organizer: European Respiratory Society Annual Congress 2008
  • Place of Presentation: Berlin Germany
  • Year and Date: 2008-10-07
• [Presentation] Bronchodilation response assessed by computed tomography in chronic obstructive pulmonary disease (COPD) (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Odajima N, Ito Y, Nagai K, Betsuyaku T, Nishimura M
  • Organizer: European Respiratory Society Annual Congress 2008
  • Place of Presentation: Berlin Germany
  • Year and Date: 2008-10-05
• [Presentation] EMS10-2 Laminills α5 and γ2 and VEGF are Down-regulated in Lung in Cigarette Smoke-exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk TL, Nguyet M. Nguyen, Senior RM, Nishimura M
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] アレルギー性気道炎症モデル及び喘息患者における気道被覆液中のカルボニル化蛋白の検討 (2008)
  • Author(s): 長井桂, 別役智子, 今野哲, 伊藤洋子, 南須原康行, 檜澤伸之, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] PP772線維化肺におけるcatalase発現の検討 (2008)
  • Author(s): 小田島奈央, 別役智子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] COPDの気流制限に及ぼす3次元CT画像で評価した気腫病変と気道病変の関与 (2008)
  • Author(s): 長谷川大, 南須原康行, 牧田比呂仁, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] MS255・PP695単回喫煙暴露マウスモデルでの好中球性炎症および細気管支上皮のケモカイン産生におよぼす加齢の影響 (2008)
  • Author(s): 守山千夏, 別役智子, 伊藤洋子, 南須原康行, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] 臨床安定期の中・高年気管支喘息患者における気流制限と肺CT3次元気道解析でみた気道病変との関係 (2008)
  • Author(s): 清水薫子, 南須原康行, 長谷川大, 牧田比呂仁, 今野哲, 別役智子, 西村正治
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸 : 神戸コンベンションセンター
  • Year and Date: 2008-06-16
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke (CS) Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Contribution of airway disease and emphysema to airflow limitation in chronic obstructive pulmonary disease (COPD) assessed by three-dimensional computed tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Aging affects lipopolysaccaride (LPS)-induced upregulation of heme oxygenase-1 (HO-1) in the lungs and alveolar macrophages (AMs) (2008)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Aged mice exhibit enhanced expression of chemokines in bronchiolar epithelium and rapid neutrophil accumulation in response to single cigarette smoke (CS) exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society InternationalConference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils mediate albumin carbonylation in the epithelial lining fluid during allergic airway inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Decreased catalase expression in bronchiolization and squamous metaplasia in lung fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF are down-regulated in lung in cigarette smoke (CS)-exposed mice and emphysema subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T, Nguyen MN, Senior RM, Nishimura M
  • Organizer: The 104th American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada
  • Year and Date: 2008-05-20
• [Presentation] Progressive Infiltration of Lymphocytes and Upregulation of MIP-3alpha/CCL20 after Cessation of Cigarette Smoke(CS)Exposure in Aged Mice (2008)
  • Author(s): Betsuyaku T, Moriyama C, Ito Y, Hamamura I, Hata J, Takahashi H, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aging Affects Lipopolysaccaride (LPS)-Induced Upregulation.of Heme Oxygenase-1 (HO-1) in the Lungs and Alveolar Macrophages (AMs) (2008)
  • Author(s): Ito Y, Betsuyaku T, Moriyama C, Nasuhara Y, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Eosinophils Mediate Albumin Carbonylation in the Epithelial Lining Fluid during Allergic Airway Inflammation (2008)
  • Author(s): Nagai K, Betsuyaku T, Konno S, Ito Y, Nasuhara Y, Hizawa N, Kondo T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO. TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Contribution of Airway Disease and Emphysema to Airflow Limitation in Chronic Obstructive Pulmonary Disease (COPD) Assessed by Three-dimensional Computed Tomography (2008)
  • Author(s): Hasegawa M, Nasuhara Y, Makita H, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Decreased Catalase Expression in Bronchiolization and Squamous Metaplasia in Lung Fibrosis (2008)
  • Author(s): Odajima N, Betsuyaku T, Nasuhara Y. Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Laminins alpha5 and gamma2 and VEGF Are Down-Regulated in Lung in Cigarette Smoke (CS)-Exposed Mice and Emphysema Subjects (2008)
  • Author(s): Suzuki M, Betsuyaku T, Nasuhara Y, Kaga K, Kondo S, Hamamura I, Adair-Kirk T,Nguyen NM, Senior RM, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Aged Mice Exhibit Enhanced Expression of Chemokines in Bronchiolar Epithelium and Rapid Neutrophil Accumulation in Response to Single Cigarette Smoke (CS) Exposure (2008)
  • Author(s): Moriyama C, Betsuyaku T, Ito Y, Hamamura I, J. Hata J, Takahashi H. Nasuhara Y. Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20
• [Presentation] Relationship between airflow limitation and wall area, airway luminal area measured by three-dimensional computed tomography in bronchial asthma (2008)
  • Author(s): Shimizu K, Nasuhara Y, Hasegawa M, Makita H, Konno S, Betsuyaku T, Nishimura M
  • Organizer: The 104^<th> American Thoracic Society International Conference
  • Place of Presentation: Toronto Canada : METRO TORONTO CONVENTION CENTRE
  • Year and Date: 2008-05-20