Role of carbonyl stress on renal circulation and development of hypertension

• Project/Area Number: 20590970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: MORI Takefumi Tohoku University, 病院, 准教授 (40375001)
• Co-Investigator(Renkei-kenkyūsha): ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613) ; NAKAYAMA Masaaki 福島県立医科大学, 医学部, 教授 (60217940)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 酸化ストレス / 糖終末代謝産物 / 慢性腎臓病 / 高血圧 / メチルグリオキサール / カルボニルストレス / ミトコンドリア / 尿細管 / 腎血流 / カルボニル物質 / 腎循環

Research Abstract

Carbonyl compound methylglyoxal induced salt sensitive hypertension, insulin resistance and renal injury which involves in the pathogenesis of chronic kidney disease. These mechanisms are associated with enhanced renal NAD(P)H oxidase, tubular oxygen metabolism and mitochondrial electron chain transport which could result in enhanced medullary carbonyl/oxidative stress and ischemia.

Research Products

• [Journal Article] Skin advanced glycation end product accumulation and muscle strength among adult men. (2011)
  • Author(s): Haruki Momma, Kaijun Niu, Yoritoshi Kobayashi, Lei Guen, Mika Sato, Hui Guo, Masahiko Chujo, Atsushi Otomo, Cui Yufei, Hiroko Tadaura, Tatsunori Saito, Takefumi Mori, Toshio Miyata, RyoichiNagatomi.
  • Journal Title: European Journal of Applied Physiology in Press
  • Peer Reviewed
• [Journal Article] AKI発症と酸化/カルボニルストレス (2011)
  • Author(s): 森建文、宮田敏男、佐藤博、伊藤貞嘉
  • Journal Title: Modern Physician Vol.31No.1 Pages: 30-33
• [Journal Article] Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure. (2010)
  • Author(s): Susumu Ogawa, Keisuke Nakayama, Masaaki Nakayama, Takefumi Mori, Masato Matsushima, Masashi Okamura, Miho Senda, Kazuhiro Nako, Toshio Miyata, Sadayoshi Ito.
  • Journal Title: Hypertension. 56(3) Pages: 471-476
  • Peer Reviewed
• [Journal Article] Significance of Advanced Glycation End Products in Aging-Related Disease. (2010)
  • Author(s): Ryoji Nagai, Takefumi Mori, Yasuhiko Yamamoto, Yuichi Kaji, Yoshikazu Yonei
  • Journal Title: Anti-Aging Medicine. 7(10) Pages: 112-119
  • NAID: 130000428490
  • Peer Reviewed
• [Journal Article] アンジオテンシンIIによる腎髄質機能調節 (2010)
  • Author(s): 森建文
  • Journal Title: 日腎会誌 Volume: 52(2) Pages: 114-119
  • NAID: 10026289800
• [Journal Article] 基礎的病態を理解する:腎血流調節 (2010)
  • Author(s): 森建文
  • Journal Title: 循環器臨床サピア Volume: 7 Pages: 80-89
• [Journal Article] アルブミン尿の出現機序と心血管病との関連 (2010)
  • Author(s): 森建文
  • Journal Title: Medical Science Digest Volume: Vol36(6) Pages: 12-15
• [Journal Article] 糸球体における循環器調節 (2010)
  • Author(s): 細谷拓真
  • Journal Title: Pharma Medica Volume: Vol28(2) Pages: 49-53
• [Journal Article] CKD合併高血圧患者における血圧日内変動とオルメサルタンの特徴 (2010)
  • Author(s): 堀内正嗣
  • Journal Title: Medical Tribune Volume: 11(4) Pages: 14-15
• [Journal Article] アンジオテンシンIIと微小循環障害 (2010)
  • Author(s): 千田美穂
  • Journal Title: 最新医学 Volume: 第65巻 Pages: 42-51
• [Journal Article] 利尿薬 (2010)
  • Author(s): 中澤かほり
  • Journal Title: レジデント Volume: Vol3(3) Pages: 43-49
• [Journal Article] Significance of Advanced Glycation End Products in Aging-Related Disease. (2010)
  • Author(s): Ryoji Nagai
  • Journal Title: Anti-Aging Medicine. Volume: 7(10) Pages: 112-119
  • Peer Reviewed
• [Journal Article] Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure. (2010)
  • Author(s): Takuo Hirose
  • Journal Title: Am J Physiol Renal Physiol. Volume: 299(1) Pages: 128-34
  • Peer Reviewed
• [Journal Article] Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of aneiotensin II blockade. (2010)
  • Author(s): Genei Ihara
  • Journal Title: J Hypertens. Volume: 11 Pages: 2289-98
  • Peer Reviewed
• [Journal Article] Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure. (2010)
  • Author(s): Susumu Ogawa
  • Journal Title: Hypertension Volume: 56(3) Pages: 471-6
  • Peer Reviewed
• [Journal Article] A novel clinical biomarker for myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis. (2010)
  • Author(s): Takefumi Mori
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 37(9) Pages: 877-8
  • Peer Reviewed
• [Journal Article] Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy. (2009)
  • Author(s): Susumu Ogawa , Hiroyuki Kobori, Naro Ohashi, Maki Urushihar, Akira Nishiyama, Takefumi Mori, Tsuneo Ishizuka, Kazuhiro Nako, Sadayoshi Ito.
  • Journal Title: Biomark Insights. 4 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Methylglyoxal Contributes to the Development of Insulin Resistance and Salt Sensitivity in Sprague Dawley Rats. (2009)
  • Author(s): Qi Guo, Takefumi Mori, Jiang Yue, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Ying Sun, Takuma Hosoya, Akihiro Kawamata, Susumu Ogawa, Masaaki Nakayama, Toshio Miyata, Sadayoshi Ito.
  • Journal Title: J.Hypertens. 27(8) Pages: 1664-1671
  • Peer Reviewed
• [Journal Article] Effects of renal perfusion pressure on renal medullary H2O2 and NO production. (2009)
  • Author(s): Chunhua Jin, Chunyan Hu, Aaron Polichnowski, Takefumi Mori, Meredith Skelton, Sadayoshi Ito, Allen W.Cowley, Jr.
  • Journal Title: Hypertension. 53(6) Pages: 1048-1053
  • Peer Reviewed
• [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease. (2009)
  • Author(s): Takefumi Mori, Sadayoshi Ito.
  • Journal Title: IMARS highlights. 4(1) Pages: 15-15
• [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease (2009)
  • Author(s): 森建文
  • Journal Title: IMARS highlights. 4(1) Pages: 15-15
  • Peer Reviewed
• [Journal Article] Carbonyl stress in hypertension, insulin resistance and chronic kidney disease (2009)
  • Author(s): Takefumi Mori, 他
  • Journal Title: IMARS highlights 4 Pages: 15-15
• [Journal Article] Methylglyoxal Contributes to the Development of Insulin Resistance and Salt Sensitivity in Sprague Dawley Rats (2009)
  • Author(s): Qi Guo, 他
  • Journal Title: J. Hypertens (In Press)
  • Peer Reviewed
• [Journal Article] Blockade of angiotensin II type-1 receptor increases salt sensitivity in Sprague Dawley rats (2009)
  • Author(s): SatoshiEndo, 他
  • Journal Title: Hypertens Res (In Press)
  • Peer Reviewed
• [Journal Article] Effects of renal perfusion pressure on renal.medullary H202 and NO production (2009)
  • Author(s): Chunhua Jin, 他
  • Journal Title: Hypertension (In Press)
  • Peer Reviewed
• [Journal Article] 慢性腎臓病の進展に対するMethylglyoxalの影響 (2008)
  • Author(s): 森建文、陳献廣、胡春艶、大崎雄介、朱万君、米城淑美、郭〓、中道崇、細谷拓真、長澤将、井上英行、小川晋、中山昌明、伊藤貞嘉
  • Journal Title: Therapeutic Research 29(11) Pages: 1884-1886
• [Journal Article] High Perfusion Pressure Accelerates Renal Injury in Salt-Sensitive Hypertension (2008)
  • Author(s): Takefumi Mori, 他
  • Journal Title: J Am Soc Nephrol 19 Pages: 1472-1482
  • Peer Reviewed
• [Journal Article] 慢性腎臓病の進展に対するMethylglyoxalの影響 (2008)
  • Author(s): 森建文, 他
  • Journal Title: Therapeutic Research 28 Pages: 1884-1886
  • Peer Reviewed
• [Presentation] アンジオテンシンIIによる腎尿細管ミトコンドリア酸化ストレスの役割 (2011)
  • Author(s): 森建文, 他
  • Organizer: 第84回日本内分泌学会学術総会(口演)
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-21
• [Presentation] Angiotensin II Increases Mitochondrial Reactive Oxygen Species through Mitochondrial Respiratory Chain in Medullary Thick Ascending Limb of the Rat Kidney (2010)
  • Author(s): Yi Lu, Takefumi Mori, Chunyan Hu, Yusuke Ohsaki,Bryan C Dickinson, Christopher J Chang, Allen W Cowley Jr, Sadayoshi Ito.
  • Organizer: 64^<th> Council for High Blood Pressure Research
  • Place of Presentation: Washington DC ,USA(Poster)
  • Year and Date: 2010-10-14
• [Presentation] 慢性腎臓病の心腎血管障害に対するカルボニルストレスの役割 (2010)
  • Author(s): 森建文
  • Organizer: 第40回日本腎臓学会東部学術大会
  • Place of Presentation: 台湾
  • Year and Date: 2010-09-24
• [Presentation] リアルタイムイメージングによる腎尿細管上皮細胞のブドウ糖誘導性ミトコンドリア酸化ストレスの検討(若手希望) (2010)
  • Author(s): 芦毅、森建文、宮田敏男、伊藤貞嘉
  • Organizer: 第20回メイラード学会(口演)
  • Place of Presentation: 東京
  • Year and Date: 2010-09-17
• [Presentation] Drug discovery and development from the academia targeting carbonyl stress in renal disease Sunday (2010)
  • Author(s): Takefumi Mori
  • Organizer: International Forum on Advances in Diabetes Complications
  • Place of Presentation: 台湾
  • Year and Date: 2010-07-18
• [Presentation] Enhanced oxidative and carbonyl stress predicts salt sensitive in obese young adults. (2010)
  • Author(s): Takefumi Mori
  • Organizer: Experimental Biology2010
  • Place of Presentation: 米国
  • Year and Date: 2010-04-27
• [Presentation] Enhanced oxidative and carbonyl stress predicts salt sensitive in obese young adults. (2010)
  • Author(s): Takefumi Mori, Akihiro Kawamata, Takuma Hosoya, Yoshimi Yoneki, Eiko Mitsui, Yoko Hasegawa, Michi Ota, Megumi Ito, Hiromi Sato, Shigeru Kabayama, Sadayoshi Ito, Wataru Hida
  • Organizer: Experimental Biology 2010
  • Place of Presentation: California, USA (Oral and Poster)
  • Year and Date: 2010-04-26
• [Presentation] Carbonyl and oxidative stress may predict salt sensitivity of hypertension in obese young adults (2010)
  • Author(s): Takefumi Mori, Akihiro Kawamata, Takuma Hosoya, Yoshimi Yoneki, Eiko Mitsui, Yoko Hasegawa, Michi Ohta, Shigeru Kabayama, Kyozo Suyama, Toshinobu Sato, Takuo Hirose, Masaaki Nakayama, Toshio Miyata, Yutaka Imai, Sadayoshi Ito, Wataru Hida.
  • Organizer: ISN nexus
  • Place of Presentation: Kyoto, Japan (Poster)
  • Year and Date: 2010-04-16
• [Presentation] Carbonyl stress mediated myocardial fi brosis and renal injury in Dahl salt sensitive rats (2010)
  • Author(s): Takefumi Mori, Qi Guo, Chunyan Hu, Xianguang Chen, Yusuke Ohsaki, Yoshimi Yoneki, Toshio Miyata, Masayuki Kanazawa, Masahiro Kohzuki, Sadayoshi Ito.
  • Organizer: ISN nexus
  • Place of Presentation: Kyoto, Japan (Poster)
  • Year and Date: 2010-04-16
• [Presentation] Carbonyl stress mediated myocardial fi brosis and renal injury in Dahl salt sensitive rats (2010)
  • Author(s): Takefumi Mori
  • Organizer: ISN nexus
  • Place of Presentation: 京都
  • Year and Date: 2010-04-16
• [Presentation] Carbonyl and oxidative stress may predict salt sensitivity of hypertension in obese young adults (2010)
  • Author(s): Takefumi Mori
  • Organizer: ISN nexus
  • Place of Presentation: 京都
  • Year and Date: 2010-04-16
• [Presentation] Carbonyl stress mediated cardio-renal connection in Dahl salt sensitive rats. (2010)
  • Author(s): Qi Guo, Takefumi Mori, Xianguang Chen, Chunyan Hu Yusuke Ohsaki, Yoshimi Yoneki, Toshio Miyata, Sadayoshi Ito.
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto (Poster)
  • Year and Date: 2010-03-28
• [Presentation] メチルグリオキサール(MG)の糖尿病合併症進展予測因子としての検討 (2009)
  • Author(s): 森建文
  • Organizer: 第7回腎と高血圧
  • Place of Presentation: 東京
  • Year and Date: 2009-12-05
• [Presentation] 食品中のカルボニルに起因する腎障害 (2009)
  • Author(s): 森建文
  • Organizer: 第19回日本メイラード学会
  • Place of Presentation: 金沢
  • Year and Date: 2009-11-20
• [Presentation] 慢性腎臓病の腎、心血管障害に対するカルボニルストレスの役割 (2009)
  • Author(s): 森建文
  • Organizer: 第13回日本心血管内分泌代謝学会学術総会(口演)
  • Place of Presentation: 大宮
  • Year and Date: 2009-10-24
• [Presentation] 慢性腎臓病の腎、心血管障害に対するカルボニルストレスの役割 (2009)
  • Author(s): 森建文
  • Organizer: 第13回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 2009-10-24
• [Presentation] Role of Carbonyl Stress on Pathogenesis of Chronic Kidney Disease. (2009)
  • Author(s): T Mori, Q Guo, M Nakayama, S Ogawa, K Suyama, T Miyata, S Ito.
  • Organizer: 10^<th> International Symposium on the Maillard Reaction.
  • Place of Presentation: Cairns, Australia (Oral invited speker)
  • Year and Date: 2009-08-31
• [Presentation] 慢性腎臓病の進展因子に対するMethylglyoxalの役割 (2009)
  • Author(s): 郭其, 森建文, 大崎雄介, 米城淑美, 江悦, 胡春艶, 中道崇, 細谷拓真, 小川晋, 中山昌明, 佐藤博, 宮田敏男, 伊藤貞嘉
  • Organizer: 第52回日本腎臓学会学術総会(口演)
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-04
• [Presentation] Losartan reverse thiazide diuretics-exacerbated insulin resistance through modulation capillary density in skeletal muscle in fructose-fed rats. (2009)
  • Author(s): Qi Guo, Takefumi Mori, Chunyan Hu, Yusuke Osaki, Yoshimi Yoneki, Takashi Nakamichi, Takuma Hosoya, Hiroshi Sato, Sadayoshi Ito.
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation.
  • Place of Presentation: Matsushima, Miyagi, Japan (Peer reviewed, Poster)
  • Year and Date: 2009-06-03
• [Presentation] Methylglyoxalのメラミン腎障害に及ぼす影響 (2009)
  • Author(s): 森建文, 郭其, 孫頴, 大崎雄介, 胡春艶, 佐藤博, 須山享三, 宮田敏男, 伊藤貞嘉
  • Organizer: 第52回日本腎臓学会学術総会(口演)
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-03
• [Presentation] Role of Carbonyl Stress on Pathogenesis of Chronic Kidney Disease (2009)
  • Author(s): 森建文
  • Organizer: 10th International Symposium on the Maillard Reaction
  • Place of Presentation: Cairns, Australia
• [Presentation] Carbnyl Stress Mediated Myocardial Fibrosis and Renal Injury in Dahl Salt Sensitive Rats. (2009)
  • Author(s): 森建文
  • Organizer: Satellite Symposium of the 36th Congress of the International Union of physiological Sciences
  • Place of Presentation: 東京
• [Presentation] メチルグリオキサールの食塩感受性高血圧を介した慢性腎臓病進展機序 (2008)
  • Author(s): 森建文, 郭〓, 江悦, 胡春艶, 大崎雄介, 中道崇, 細谷拓真, 長澤将, 井上英行, 小川晋, 中山昌明、宮田敏男、伊藤貞嘉
  • Organizer: 第20回日本糖尿病性腎症研究会(口演)
  • Place of Presentation: 東京
  • Year and Date: 2008-12-07
• [Presentation] メチルグリオキサールの食塩感受性高血圧を介した慢性腎臓病進展機序 (2008)
  • Author(s): 森建文, 他
  • Organizer: 第20回日本糖尿病性腎症研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-07
• [Presentation] 生活習慣病および慢性腎臓病におけるMethylglyoxalの役割 (2008)
  • Author(s): 郭〓, 他
  • Organizer: 第6回腎と高血圧Update
  • Place of Presentation: 東京
  • Year and Date: 2008-12-06
• [Presentation] メチルグリオキサールのインスリン抵抗性に対する作用と食塩感受性との関連 (2008)
  • Author(s): 郭〓、森建文、江悦、大崎雄介、米城淑美、胡春艶、中道崇、細谷拓真、長澤将、井上英行、小川晋、中山昌明、宮田敏男、伊藤貞嘉
  • Organizer: 第31回日本高血圧学会総会(ポスター)
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-11
• [Presentation] メチルグリオキサールのインスリン抵抗性に対する作用と食塩感受性との関連 (2008)
  • Author(s): 郭〓, 他
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-11
• [Presentation] 高血圧による腎内酸化ストレスの上昇メカニズム (2008)
  • Author(s): 胡春艶, 他
  • Organizer: 第31回日本高血圧学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-09
• [Presentation] Effects of renal decapsulation upon arterial pressure induced medullary oxidative stress (2008)
  • Author(s): Chunhua Jin, 他
  • Organizer: American Heart Association High Blood Pressure Council
  • Place of Presentation: Atlanta, USA
• [Remarks] ホームページ等
  • URL: http://www.int2.med.tohoku.ac.jp