Pathophysiology of Parkison disease : a review of cortico-basal ganglia loop model
Project/Area Number |
20591023
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Kyoto University |
Principal Investigator |
SAWAMOTO Nobukatsu Kyoto University, 医学研究科, 助教 (90397547)
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Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | パーキンソン病 / 神経機能画像 / ドパミン / 大脳皮質基底核ループ |
Research Abstract |
In basal ganglia disorders, it is essential to clarify 'network dysfunction' in order to understand pathophysiological mechanisms from neuronal cell degeneration to clinical symptoms. Since the basal ganglia have no direct motor output, the network dysfunction should results in disordered outputs from the motor cortex reflecting the clinical symptoms. The present studies suggest that compensatory function of the cerebellum as well as disrupted function of cortico-basal ganglia loop should be considered in pathophydiological mechanisms of Parkinson disease.
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Report
(4 results)
Research Products
(111 results)
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[Journal Article] Alexithymia and regional gray matter alterations in schizophrenia.2011
Author(s)
Kubota M, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Age-related cortical thinning in schizophrenia.2011
Author(s)
Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
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Journal Title
Schizophr Res 125
Pages: 21-29
NAID
Related Report
Peer Reviewed
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[Journal Article] Alexithymia and regional gray matter alterations in schizophrenia.2011
Author(s)
Kubota M, Miyata J, Hirao K, FujiwaraH, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
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Journal Title
Neurosci Res.
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Age-related cortical thinning in schizophrenia.2011
Author(s)
Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
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Journal Title
Schizophr Res.
Volume: 125
Pages: 21-29
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia.2010
Author(s)
Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
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Journal Title
Schizophr Res 119
Pages: 232-239
NAID
Related Report
Peer Reviewed
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[Journal Article] Investigating association of brain volumes with intracranial capacity in schizophrenia.2010
Author(s)
Ueda K, Fujiwara H, Miyata J, Hirao K, Saze T, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Murai T.
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Journal Title
Neuroimage 49
Pages: 2503-2508
Related Report
Peer Reviewed
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[Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia.2010
Author(s)
Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
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Journal Title
Schizophr Res.
Volume: 119
Pages: 232-239
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia.2010
Author(s)
Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
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Journal Title
Schizophr Res. (In press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Investigating association of brain volumes with intracranial capacity in schizophrenia.2010
Author(s)
Ueda K, Fujiwara H, Miyata J, Hirao K, Saze T, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Murai T.
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Journal Title
Neuroimage. 49
Pages: 2503-2508
Related Report
Peer Reviewed
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[Journal Article] Brain volume and dysexecutive behavior in schizophrenia.2009
Author(s)
Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry 33
Pages: 1255-1260
Related Report
Peer Reviewed
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[Journal Article] Brain volume and dysexecutive behavior in schizophrenia.2009
Author(s)
Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry. 33
Pages: 1255-1260
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
澤本伸克、山内浩、福山秀直
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Journal Title
神経放射線学的検査 : 内科学書 改訂第7版 : (小川聡総編集)(中山書店)
Pages: 229-232
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[Journal Article] Hemispheric asymmetry of the arcuate fasciculus : a preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test.2008
Author(s)
Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N, Fukuyama H, Takahashi R, Ikeda A
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Journal Title
J Neurol 255
Pages: 1703-1711
Related Report
Peer Reviewed
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[Journal Article] Hemispheric asymmetry of the arcuate fasciculus : a preliminary diffusion tensor tractography study in patients with unilateral language dominance defined by Wada test.2008
Author(s)
Matsumoto R, Okada T, Mikuni N, Mitsueda-Ono T, Taki J, Sawamoto N, Hanakawa T, Miki Y, Hashimoto N. Fukuyama H, Takahashi R, Ikeda A
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Journal Title
J Neurol 255
Pages: 1703-1711
Related Report
Peer Reviewed
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[Presentation] 依存の脳を観る2010
Author(s)
澤本伸克
Organizer
依存学ことはじめ
Place of Presentation
京都市、京都大学国際交流ホール
Year and Date
2010-03-14
Related Report
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[Presentation] 脳波と機能的MRIの同時計測(EEG-fMRI)によるてんかん焦点の同定と関連するネットワークの評価 : 皮質脳波との比較2008
Author(s)
井内盛遠, 松本理器, 洋本伸克, 中川朋一, 浦山慎一, 美馬達哉, 三國信啓, 穴見公隆, 栗屋智就, 加藤武雄, 福山秀直, 高橘良輔, 池田昭夫
Organizer
第38回日本臨床神経生理学会学術大会
Place of Presentation
神戸
Year and Date
2008-11-22
Related Report
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