Clinicopathological study on functional subdivisions of the globus pallidus internus in dystonias.

• Project/Area Number: 20591025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: The University of Tokushima
• Principal Investigator: GOTO Satoshi The University of Tokushima, 病院, 講師 (50240916)
• Co-Investigator(Kenkyū-buntansha): KAJI Ryuji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00214304)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 臨床神経生理学 / ジストニア / パーキンソン病 / 淡蒼球内節 / 線条体 / ストリオゾーム / 脳深部刺激術 / 神経活動電位 / コンパートメント構造 / パーキンソン

Research Abstract

Altered neural activity of the globus pallidus (GP) due to dysregulation of striatal dopamine functions has been proposed as a major cause of dystonia genesis. Based on the clinico-physiological data obtained from the patients with dystonia, we found that abnormal patterned activities of the posteroventral portion of the GPi have a tight link with occurrence o f dystonia symptoms. In addition, our data on the experimental animal models that include tran sgenic mice showed that striatal striosome-matrix dopamine systems could be involved in the dystonia genesis.

Research Products

• [Journal Article] Cyclin-dependent kinase 5 with phosphorylation of tyrosine 15 residue is enriched in striatal matrix compartment in adult mice. (2011)
  • Author(s): R.Morigaki, W.Sako, S.Okita, J.Kasahara, H.Yokoyama, S.Nagahiro, R.Kaji, S.Goto
  • Journal Title: Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] Identification and localization of a neuron-specific isoform of TAF1 in rat brain : implications for neuropathology of DYT3 dystonia. (2011)
  • Author(s): W.Sako, R.Morigaki, R.Kaji, I.Tooyama, S.Okita, K.Kitazato, S.Nagahiro, AM Graybiel, S.Goto
  • Journal Title: Neuroscience
  • Peer Reviewed
• [Journal Article] Bilateral pallidal deep brain stimulation in primary Meige syndrome. (2011)
  • Author(s): W.Sako, R.Morigaki, Y.Mizobuchi, T.Tsuzuki, H.Ima, Y.Ushio, S.Nagahiro, R.Kaji, S.Goto.
  • Journal Title: Parkinsonism Relat Disord 17 Pages: 123-125
  • Peer Reviewed
• [Journal Article] Bilateral pallidal deep brain stimulation in primary Meiges syndrome. (2011)
  • Author(s): Sako W, et al.
  • Journal Title: Parkinsonism Relat Disord. Volume: 17 Pages: 123-125
  • Peer Reviewed
• [Journal Article] Olfactory type G-protein alpha subunit (G・olf) in striosome-matrix dopamine systems in adult mice. (2010)
  • Author(s): W.Sako, R.Morigaki, S.Nagahiro, R.Kaji, S.Goto
  • Journal Title: Neuroscience 170 Pages: 497-502
  • Peer Reviewed
• [Journal Article] Long-term suppression of Meige syndrome after pallidal stimulation. (2010)
  • Author(s): N.Inoue, S.Nagahiro, R.Kaji, S.Goto
  • Journal Title: Mov Disord 25 Pages: 1756-1758
  • Peer Reviewed
• [Journal Article] Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice. (2010)
  • Author(s): Sako W, et al.
  • Journal Title: Neuroscience Volume: 170 Pages: 497-502
  • Peer Reviewed
• [Journal Article] Long-term suppression of Meige syndrome after pallidal stimulation. (2010)
  • Author(s): Inoue N, et al.
  • Journal Title: Mov Disrd. Volume: 25 Pages: 1756-1758
  • Peer Reviewed
• [Journal Article] Long-term suppression of Meige syndrome after pallidal stimulation (2010)
  • Author(s): Inoue N, et al.
  • Journal Title: Mov.Disord. (In press)
  • Peer Reviewed
• [Journal Article] Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson's disease. (2009)
  • Author(s): W.Sako, M.Nishio, T.Maruo, H.Shimazu, K.Matsuzaki, T.Tamura, N.Murase, Y.Ushio, S.Nagahiro, R.Kaji, S.Goto
  • Journal Title: Mov Disord 24 Pages: 1076-1079
  • NAID: 10024369634
  • Peer Reviewed
• [Journal Article] Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson's disease. (2009)
  • Author(s): Sako W, et al.
  • Journal Title: Mov.Disord. 24 Pages: 1076-1079
  • Peer Reviewed
• [Journal Article] Long-term suppression of tremor by deep brain stimulation of the ventral intermediate nucleus of the thalamus combined with pallidotomy in hemiparkinsonian patients. (2009)
  • Author(s): Nishio M, et al.
  • Journal Title: J.Clin.Neurosci. 16 Pages: 1489-1491
  • Peer Reviewed
• [Journal Article] Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia. (2008)
  • Author(s): K.Sato, C.Sumi-Ichinose, R.Kaji, K.Ikemoto, W.Sako, S.Nagahiro, A.M.Graybiel, S.Goto
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 12551-12556
  • Peer Reviewed
• [Journal Article] Thalamic Vo-complex versus pallidal deep brain stimulation for focal hand dystonia. (2008)
  • Author(s): S.Goto, H.Shimazu, K.Matsuzaki, T.Tamura, N.Murase, S.Nagahiro, R.Kaji
  • Journal Title: Neurology 70 Pages: 1500-1501
  • Peer Reviewed
• [Journal Article] Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia. (2008)
  • Author(s): W.Sako, S.Goto, H.Shimazu, N.Murase, K.Matsuzaki, T.Tamura, H.Mure, Y.Tomogane, N.Arita, H.Yoshikawa, S.Nagahiro, R.Kaji
  • Journal Title: Mov Disord 23 Pages: 1929-1931
  • Peer Reviewed
• [Journal Article] Thalamic Vo-complex versus pallidal deep brain stimulation for focal hand dyatonia. (2008)
  • Author(s): Goto S, et al.
  • Journal Title: Neurology 70 Pages: 1500-1501
  • Peer Reviewed
• [Journal Article] Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia. (2008)
  • Author(s): Sako W, et al.
  • Journal Title: Movement Disorders 23 Pages: 1929-1931
  • Peer Reviewed
• [Journal Article] Differential involvement of striosomes and matrix dopamine systems in a transgenic model of dopa-responsivedystonia. (2008)
  • Author(s): Sato K, et al.
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 12551-12556
  • Peer Reviewed
• [Presentation] 薬物治療を中心としたジストニア治療戦略 (2011)
  • Author(s): 佐光亘、後藤惠
  • Organizer: 第50回日本定位・機能神経外科学会
  • Place of Presentation: 広島
  • Year and Date: 2011-01-22
• [Presentation] Molecular dissection and anatomical basis of dystonia (2008)
  • Author(s): Satoshi Goto
  • Organizer: The Movement Disorder Society's 12^<th> International Congress of Parkinson's disease and Movement Disorders
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2008-06-24
• [Presentation] Molecular dissection and anatomical basis of dystonia. (2008)
  • Author(s): S.Goto
  • Organizer: The Movement Disorder Society's 12th International Congress of Parkinson's Disease and Movement Disorders.(招待講演)
  • Place of Presentation: Chicago, USA
• [Book] Thalamic deep brain stimulation for Parkinson' s disease. (2011)
  • Author(s): R.Morigaki, S.Nagahiro, R.Kaji, S.Goto
  • Publisher: Nova Science Publishers, New York(in press)
• [Book] Current use of thalamic surgeries for treating movement disorders. (2010)
  • Author(s): R.Morigaki, S.Nagahiro, R.Kaji, S.Goto
  • Publisher: Nova Science Publishers, New York(in press)
• [Book] Striosome-matrix pathology of dystonias : a new hypothesis for dystonia genesis. Dystonia : Causes, Symptoms and Treatment. (2010)
  • Author(s): S.Goto, S.Nagahiro, R.Kaji
  • Publisher: Nova Science Publishers, New York
• [Book] Dystonia : a disorder of striosomal function? Dystonia : Causes, Symptoms and Treatment. (2010)
  • Author(s): 後藤恵
  • Publisher: Nova Science Publishers, New York
• [Book] DYT3. (2010)
  • Author(s): 後藤恵
  • Publisher: Clinical Neuroscience
• [Book] パーキンソン病のDBS治療。総合臨床 (2010)
  • Author(s): 後藤恵
• [Book] Striosome-Matrix Pathology of Dystonias : A new hypothesis for dystonia genesis (2010)
  • Author(s): Satoshi Goto.
  • Total Pages: 22
  • Publisher: Nova Science Publishers, New York
• [Book] Dystonia : Causes, Symptoms, and Treatment (2010)
  • Author(s): Satoshi Goto
  • Total Pages: 26
  • Publisher: Nova Science Publishers, New York
• [Book] 脳深部刺激療法.神経疾患最新の治療2009-2011.6.脳深部刺激療法 (2009)
  • Author(s): 後藤恵
  • Publisher: 南江堂、東京
• [Book] Parkinson病:深部脳刺激療法(DBS)の適応基準.EBM神経疾患の治療2009-2010 (2009)
  • Author(s): 後藤恵
  • Publisher: 中外医学社、東京
• [Book] 神経疾患最新の治療 (2009)
  • Author(s): 後藤 恵
  • Publisher: 南江堂
• [Remarks] ホームページ等