| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Altered neural activity of the globus pallidus (GP) due to dysregulation of striatal dopamine functions has been proposed as a major cause of dystonia genesis. Based on the clinico-physiological data obtained from the patients with dystonia, we found that abnormal patterned activities of the posteroventral portion of the GPi have a tight link with occurrence o f dystonia symptoms. In addition, our data on the experimental animal models that include tran sgenic mice showed that striatal striosome-matrix dopamine systems could be involved in the dystonia genesis.
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