Identification of a novel hepatokine that causes insulin resistance and diabetic vascular complications
Project/Area Number |
20591054
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kanazawa University |
Principal Investigator |
TAKAMURA Toshinari Kanazawa University, 医学系, 准教授 (00324111)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | エネルギー / 糖質代謝異常 / インスリン抵抗性 / 2型糖尿病 / 肝臓 / ホルモン / 分泌蛋白 / 発現遺伝子解析 |
Research Abstract |
We identified a gene encoding selenoprotein P (SeP), the hepatic expression levels of which were positively correlated with insulin resistance and hyperglycemia in patients with type 2 diabetes. SeP caused insulin resistance, at least partly, by inactivating AMPK both in vitro and in vivo.
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Report
(4 results)
Research Products
(157 results)
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[Journal Article] Aliver-derived secretory protein, selenoprotein p, causes insulin resistance.2010
Author(s)
Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Honda M, Miyamoto K, Kubota T, Kubota N, KadowakiT, Kim HJ, Lee IK, Minokoshi Y, Saito Y, TakahashiK, Yamada Y, Takakura NKaneko S
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Journal Title
Cell Metab
Volume: 12
Pages: 483-495
Related Report
Peer Reviewed
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[Journal Article] Histological course of nonalcoholic fatty liver disease in Japanese patients : tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.2010
Author(s)
Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, ZenY, Takeshita Y, Kurita S, AraiK, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S
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Journal Title
Diabetes Care
Volume: 33
Pages: 284-286
NAID
Related Report
Peer Reviewed
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[Journal Article] Histological course of nonalcoholic fatty liver disease in Japanese patients : tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.:, 20102010
Author(s)
Hamaguchi E, Takamura T, Sakurai M, Mizukoshi E, Zen Y, Takeshita Y, Kurita S, Arai K, Yamashita T, Sasaki M, Nakanuma Y, Kaneko S
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Journal Title
Diabetes Care 33
Pages: 284-286
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Peer Reviewed
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[Journal Article]2010
Author(s)
篁俊成
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Journal Title
糖尿病性ケトアシドーシス・高血糖高浸透圧症候群.「栄養塾-症例で学ぶクリニカルパール」(医学書院)
Pages: 232-238
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[Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.2009
Author(s)
Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Eto T, Misu H, Shiramoto M, Tsuru T, Irie S, Fujimura A, Kaneko S
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Journal Title
Diabetologia 52
Pages: 329-335
Related Report
Peer Reviewed
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[Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.2009
Author(s)
Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Nakamura S, Kumazaki M, Kurita S, Misu H, Togawa N, Fukushima T, Fujimura A, Kaneko S
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Journal Title
Biochem Biophys Res Commun 380
Pages: 684-688
NAID
Related Report
Peer Reviewed
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[Journal Article] Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.2009
Author(s)
Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S
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Journal Title
J Biol Chem 284
Pages: 14809-14818
NAID
Related Report
Peer Reviewed
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[Journal Article] J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes : an 8-year follow-up of relatively lean Japanese individuals.2009
Author(s)
Sakurai M, Miura K, Takamura T, Ishizaki M, Morikawa Y, Nakamura K, Yoshita K, Kido T, Naruse Y, Kaneko S, Nakagawa H
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Journal Title
Diabet Med 26
Pages: 753-759
NAID
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
御簾博文, 篁俊成
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Journal Title
活性酸素がインスリンシグナル伝達に与える影響とその二面性.,「病態解明に迫る活性酸素シグナルと酸化ストレス-癌、神経変性疾患、循環・代謝異常にかかわるレドックス制御機構と最新の技術開発-」(谷口直之, 赤池孝章, 鈴木敬一郎, 内田浩二編)(羊土社)
Pages: 212-7
Related Report
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[Journal Article]2009
Author(s)
篁俊成
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Journal Title
内分泌・代謝系 糖尿病治療薬.ナーシングムック56「みてわかる 薬の作用メカニズム&服薬指導」(藤村昭夫編)(学研メディカル秀潤社)
Pages: 126-131
Related Report
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[Journal Article]2009
Author(s)
篁俊成, 金子周一
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Journal Title
代謝臓器としての肝臓の分子生物学.「Annual Review消化器2009」(林紀夫, 日比紀文, 上西紀夫, 下瀬川徹編)(中外医学社)
Pages: 148-156
Related Report
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[Journal Article]2009
Author(s)
櫻井千佳, 篁俊成
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Journal Title
肝疾患合併時.「糖尿病最新の治療2010-2012」(河盛隆造、岩本安彦編)(南江堂)
Pages: 98-98
Related Report
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[Journal Article] Clock gene expression in peripheral leucocytes of patients with type 2 diabetes2009
Author(s)
Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Eto T, Misu H, Shiramoto M, Tsuru T, Irie S, Fujimura A, Kaneko S
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Journal Title
Diabetologia 52
Pages: 329-335
Related Report
Peer Reviewed
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[Journal Article] The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis2009
Author(s)
Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Nakamura S, Kumazaki M, Kurita S, Misu H, Togawa N, Fukushima T, Fujimura A, Kaneko S
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Journal Title
Biochem Biophys Res Commun 380
Pages: 684-688
NAID
Related Report
Peer Reviewed
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[Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.2008
Author(s)
Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T
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Journal Title
Hepatology 48
Pages: 109-118
NAID
Related Report
Peer Reviewed
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[Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pie iotropic effects2008
Author(s)
Kurita S, Takamura T, Ota T, Matsuzawa-Nagata N, Kita Y, Uno M, Nabemoto S, Ishikura K, Misu H, Ando H, Zen Y, Nakanuma Y, Kaneko S
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Journal Title
Eur J Pharmacol 588
Pages: 316-324
Related Report
Peer Reviewed
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[Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis2008
Author(s)
Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T
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Journal Title
Hepatology 48
Pages: 109-118
NAID
Related Report
Peer Reviewed
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[Journal Article] Obesity Upregulates Genes Involved in Oxidative Phospho rylation in Livers of Diabetic Patients2008
Author(s)
Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S
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Journal Title
Obesity (Silver Spring) 16
Pages: 2601-2609
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Peer Reviewed
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[Presentation]2011
Author(s)
Misu H, Ishikura K, Takayama H, Hayashi H, Ota T, Kaneko S, Takamura T
Organizer
Keystone Symposia - Obesity
Place of Presentation
Keystone Resort, Keystone, Colorado, USA
Year and Date
2011-01-16
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[Presentation] Proteasome dysfunction contributes to endoplasmic reticulum stress and insulin resistance in type 2 diabetic liver.2010
Author(s)
Otoda T , Misu H, Kurita S, Yamamoto M, Ota T, Shima K, Iseki S, Murata S, Tanaka K, Kaneko S, Takamura T
Organizer
第46回欧州糖尿病学会議(EASD),(一般演題(ポスター))
Place of Presentation
"Massan" conference and exhibition centre, Stockholm, Sweden
Year and Date
2010-09-23
Related Report
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[Presentation] Proteasome dysfunction contributes to endoplasmic reticulum stress and insulin resistance in type 2 diabetic liver2010
Author(s)
Toshiki Otoda, Hirofumi Misu, Seiichiro Kurita, Miyuki Yamamoto, Tsuguhito Ota, Kosuke R.Shima, Shoichi Iseki, Shigeo.Murata, Keiji Tanaka, Shuichi Kaneko, Toshinari Takamura
Organizer
第46回欧州糖尿病学会議(EASD)
Place of Presentation
Massanconference andexhibition centre, Stockholm, Sweden(一般演題(ポスター))
Year and Date
2010-09-23
Related Report
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[Presentation] CCR5 Ablation Prevents Insulin Resistance Induced by High-Fat Feedingor Leptin Deficiency2010
Author(s)
Ota T, Kitade H, Sawamoto K, Inoue H, Takamura T, Miyamoto K, Mukaida N, Kaneko S
Organizer
American Diabetes Association 70th Scientific Sessions
Place of Presentation
Orange County ConventionCenter, Orlando, Florida, USA(一般演題(口演))
Year and Date
2010-06-30
Related Report
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[Presentation] Glycemic control predicts for liver fibrosis progression in Japanese patients with NAFLD who underwent consecutive liver biopsies2010
Author(s)
Takeshita Y, Takamura T, Hamaguchi E, Zen Y, Misu H, Arai K, Yamashita T, Mizukoshi E, Sasaki M, Nakahama Y, Kaneko S
Organizer
45th Annual Meeting of the European Associationfor the Study of the Liver
Place of Presentation
Reed Messe Wien Exhibition & Congress Center, Austria, Vienna
Year and Date
2010-04-15
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[Presentation] Adipose tissue derived mesenchymal stem cells are capable to modulate liver inflammation in mouse of non-alcoholic steatohepatitis.2009
Author(s)
Seki A, Sakai Y, Tatsumi I, Komura T, Fujinaga H, Honda M, Takamura T, Ochiya T, Kaneko S
Organizer
60th American Association for the Study of Liver Diseases, Annual Meeting
Place of Presentation
John B. Hynes Convention Center, Boston, (USA)
Year and Date
2009-11-03
Related Report
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[Presentation] 副腎不全、Cushing徴候、BigIGF2誘発性低血糖を来した副腎癌剖検例2009
Author(s)
石倉和秀, 田治孔明, 竹下有美枝, 上山奈央美, 濱口えりか, 御簾博文, 笠原寿郎, 鈴木潮人, 大井章史, 押野谷幸之輔, 今泉範子, 中川淳, 金子周一, 篁俊成
Organizer
第19回臨床内分泌代謝Up date
Place of Presentation
東京
Year and Date
2009-03-14
Related Report
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[Presentation] IgG関連疾患の経過中に出現したリンパ球性下垂体炎の男性例2009
Author(s)
田治孔明, 赤堀弘, 原田ゆかり, 毛利研祐, 石倉和秀, 竹下有美枝, 御簾博文, 川野充弘, 篁俊成, 林康彦, 林裕, 潰田潤一郎
Organizer
第19回臨床内分泌代謝Up date
Place of Presentation
東京
Year and Date
2009-03-13
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[Presentation] IgG4関連疾患の経過中に出現したリンパ球性下垂体炎の1男性例2008
Author(s)
田治孔明, 赤堀弘, 原田ゆかり, 毛利研祐, 石倉和秀, 竹下有美枝, 御簾博文, 篁俊成, 岩戸雅之, 林康彦, 林裕, 潰田潤一郎
Organizer
第14回北陸間脳下垂体腫瘍研究会プログラム
Place of Presentation
金沢
Year and Date
2008-09-06
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[Presentation] 抗アレルギー薬トラニラストはラツトNASHモデルのマクロファージ活性化と肝病理進展を阻止する2008
Author(s)
栗田征一郎, 篁俊成, 宇野将文, 太田嗣人, 長田直人, 喜多裕樹, 御簾博文, 安藤仁, 全陽, 中沼安二, 金子周一
Organizer
第44回日本肝臓学会
Place of Presentation
松山
Year and Date
2008-06-05
Related Report
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[Presentation] 2型糖尿病患者における食後インスジン動態、高血糖、脂質異常におよぼすインスリンアスパルトの効果2008
Author(s)
清水暁子, 安藤仁, 栗田征一郎, 永野倫子, 長田美津子, 加藤健一郎, 石倉和秀, 田治孔明, 宇野将文, 御簾博文, 吉田知孝, 金子周一, 篁俊成
Organizer
第51回日本糖尿病学会
Place of Presentation
東京
Year and Date
2008-05-24
Related Report
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[Presentation] 主観的包括的評価(SGA)は糖尿病入院患者の把握に有用か?2008
Author(s)
河野貴子, 黒川千佳, 八幡陽子, 田島奈津美, 黒川素江, 西野喜美子, 関軒裕佳, 竹森千尋, 山下千鶴子, 内潟将宏, 田治孔明, 石倉和秀, 栗田征一郎, 御簾博文, 安藤仁, 金子周一, 篁俊成
Organizer
第51回日本糖尿病学会
Place of Presentation
東京
Year and Date
2008-05-24
Related Report
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[Presentation] 抗アレルギー薬トラニラストはマクロファージの活性化とインスリン抵抗性を改善する2008
Author(s)
栗田征一郎, 宇野将文, 御簾博文, 安藤仁, 太田嗣人, 長田直人, 喜多裕樹, 乙田敏城, 全陽, 金子周一, 篁俊成
Organizer
第51回日本糖尿病学会
Place of Presentation
東京
Year and Date
2008-05-23
Related Report
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[Presentation] 糖尿病治療チームの指導ノウハウを用いた生活習慣病発症予防システムの構築2008
Author(s)
内潟将宏, 山村奈津絵, 竹森千尋, 関軒裕佳, 黒川素江, 河野貴子, 田島奈津美, 八幡陽子, 黒川千佳, 田平裕美子, 東敬一郎, 吉谷久子, 長田美津子, 米田由美, 田治孔明, 石倉和秀, 栗田征一郎, 御簾博文, 安藤仁, 金子周一, 安藤仁, 金子周一, 篁俊成
Organizer
第51回日本糖尿病学会
Place of Presentation
東京
Year and Date
2008-05-23
Related Report
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