Analysis of repression mechanism by LECT2 in rheumatoid arthritis

• Project/Area Number: 20591180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: YAMAGOE Satoshi National Institute of Infectious Diseases, 生物活性物質部, 主任研究官 (00212283)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生理活性 / 免疫学 / サイトカイン / 自己免疫疾患 / 医療・福祉

Research Abstract

We analyzed the repressive mechanism by LECT2 in rheumatoid arthritis. First, we have identified a LECT2 receptor-expressing cell type related in rheumatoid arthritis, and showed the possibility that human synoviocytes expressed the receptor of LECT2. Using those cells, we studied LECT2 effect on the proliferation of the cells, and expression of proinflammatory cytokines and several genes related to rheumatoid arthritis. We identified many genes controlled by main proinflammatory cytokines in a mouse model of rheumatoid arthritis.

Research Products

• [Journal Article] Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in D-galactosamine-sensitized mice. (2010)
  • Author(s): Dang MH., Kato H., Ueshiba H., Omori-Miyake M, Yamagoe S., Ando K, Imanishi K., Arimura Y., Haruta I., Kotani T., Ozaki M., Suzuki K., Uchiyama T., Yagi J.
  • Journal Title: Clin Immunol. 137 Pages: 311-321
  • Peer Reviewed
• [Journal Article] Possible role of LECT2 as an intrinsic regulatory factor in SEA-induced toxicity in D-galactosamine-sensitized mice (2010)
  • Author(s): Yoshioka, H., et al.
  • Journal Title: Clin.Immunol Volume: 37 Pages: 300-321
  • Peer Reviewed
• [Journal Article] Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flightmass spectrometry. (2009)
  • Author(s): Okumura A., Suzuki T., Dohmae N., Okabe T., Hashimoto Y., Nakazato K., Ohno H., Miyazaki Y., Yamagoe S.
  • Journal Title: BioScience Trends. 3 Pages: 139-43
  • Peer Reviewed
• [Journal Article] マウスコラーゲン関節炎におけるLECT2(leukocyte cell-derived chemotaxin 2)の役割の解析 (2009)
  • Author(s): 奥村彰規、山越智
  • Journal Title: リウマチ科 41 Pages: 71-79
• [Journal Article] Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (2009)
  • Author(s): 奥村彰規
  • Journal Title: BioScience Trends 3 Pages: 139-143
  • Peer Reviewed
• [Journal Article] マウスコラーゲン関節炎におけるLECT2 (leukocyte cell-derived chemotaxin2)の役割の解析 (2009)
  • Author(s): 奥村彰規
  • Journal Title: リウマチ科 41 Pages: 71-79
• [Journal Article] Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis. (2008)
  • Author(s): Okumura A., Saito T., Otani I., Kojima K., Yamada Y., Ishida-Okawara A., Nakazato K., Asano M., Kanayama K., Iwakura Y., Suzuki K., Yamagoe S.
  • Journal Title: Arthritis Rheum. 58 Pages: 413-421
  • Peer Reviewed
• [Presentation] ガラクトサミン/LPS肝障害モデルを用いたLECT2の機能解析 (2009)
  • Author(s): 奥村彰規、大川原明子、山越智
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] 敗血症におけるLECT2の役割 (2009)
  • Author(s): 大森深雪、安藤一義、上芝秀博、有村祐、山越智、鈴木和男、八木淳二
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Suppressive Role of LECT2 in Mouse Anti-Type-II Collagen Antibody-Induced Arthritis (2008)
  • Author(s): 奥村彰規、大谷功、大川原明子、岩倉洋一郎、鈴木和男、山越智
  • Organizer: 第38回日本免疫学会総会学術集会
  • Place of Presentation: 京都
• [Presentation] Suppressive Role of LECT2 in Mouse Anti-Type-II Collagen Ant ibody-Induced Arthritis (2008)
  • Author(s): 奥村彰規
  • Organizer: 第38回 日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Patent(Industrial Property Rights)] 骨吸収抑制剤 (2009)
  • Inventor(s): 国立感染症研究所長、鈴木和男
  • Industrial Property Rights Holder: 鈴木和男、山越智、山川徹
  • Filing Date: 2009-10-02