Analysis of the mechanism of infantile allergic diseases using the system to differentiate human ES cells into immune cells

• Project/Area Number: 20591244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokyo
• Principal Investigator: MA Hou The University of Tokyo, 医科学研究所, 特任研究員 (20378748)
• Co-Investigator(Kenkyū-buntansha): TSUJI Kohichiro 東京大学, 医科学研究所, 准教授 (50179991)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ヒト胚性幹細胞(ES細胞) / 乳児アレルギー疾患 / 肥満細胞 / 好酸球 / 乳児アレルギー / 結合組織型肥満細胞 / ES細胞 / アレルギー / ヒトES細胞 / アトピー性皮膚炎 / 胎仔肝 / ストローマ細胞 / 多能性造血細胞 / 胎生期造血

Research Abstract

We succeeded the production of human mast cells and eosinophils, major immune effecter cells in allergic diseases, from hematopoietic cells derived human ES cells by coculture with AGMs-3 cells which are stromal cell line established from murine embryonic AGM region. Since this system reflect the generation and development of these immune cells in human embryo, it is expected to be a useful tool for analysis of the mechanism causing infantile allergic diseases.

Research Products

• [Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents inTokyo, Japan. (2011)
  • Author(s): Iwatsuki-Horimoto K, Horimoto T, Tamura D, Kiso M, Kawakami E, Hatakeyama S, Ebihara Y, Koibuchi T, Fujii T, Takahashi K, Shimojima M, Sakai-Tagawa Y, Ito M, Sakabe S, Iwasa A, Takahashi K, Ishii T, Gorai T, Tsuji K, Iwamoto A, Kawaoka Y
  • Journal Title: J Clinic Microbiol (掲載確定)
  • Peer Reviewed
• [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome. (2011)
  • Author(s): Tsuda M, Ebihara Y, Mochizuki S, Uchimaru K, Tojo A, Tsuji K
  • Journal Title: Br J Haematol (掲載確定)
  • Peer Reviewed
• [Journal Article] ヒトES細胞から血液細胞への分化誘導 (2011)
  • Author(s): 辻浩一郎
  • Journal Title: Cytometry Research (掲載確定)
  • NAID: 10028165325
  • Peer Reviewed
• [Journal Article] Sero-prevalence of pandemic (H1N1) 2009 influenza A virus among schoolchildren and their parents in Tokyo, Japan. (2011)
  • Author(s): Iwatsuki-Horimoto K, et al.
  • Journal Title: J Clinic Microbiol Volume: (掲載確定in press, in press掲載確定)
  • Peer Reviewed
• [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukemia with adult Down syndrome. (2011)
  • Author(s): Tsuda M, et al.
  • Journal Title: Br J Haematol Volume: (掲載確定in press, in press掲載確定)
  • Peer Reviewed
• [Journal Article] ヒトES細胞から血液細胞への分化誘導 (2011)
  • Author(s): 辻浩一郎
  • Journal Title: Cytometry Research Volume: (掲載確定in press,印刷中 掲載確定)
  • NAID: 10028165325
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells. (2010)
  • Author(s): Funayama K, Saito-Kurimoto Y, Ebihara Y, Shimane Y, Nomura H, Tsuji K, Asano S
  • Journal Title: Biochem Biophys Res Commun 396 Pages: 193-198
  • Peer Reviewed
• [Journal Article] A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. (2010)
  • Author(s): Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda Z, Okuda T, Oda H, Tsuji K, Honda H H
  • Journal Title: Dev Biol 345 Pages: 226-236
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells. (2010)
  • Author(s): Funayama K, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 396 Pages: 193-198
  • Peer Reviewed
• [Journal Article] A 5'untranslated region containing the IRES element in the Runxl gene isrequired for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. (2010)
  • Author(s): Nagamachi A*, et al.(*equally contributed)
  • Journal Title: Dev Biol Volume: 345 Pages: 226-236
  • Peer Reviewed
• [Journal Article] IRES-dependent expression is required for AML 1-mediated angiogenesis and hematopoiesis and for AML 1 fusion protein-induced leukemogenesis. (2010)
  • Author(s): Miyazaki K, Ma F, Yamasaki N, Oda H, Miyazaki M, Honda Z, Okuda T, Tsuji K, Honda H
  • Journal Title: Dev Biol. (in press.)
  • Peer Reviewed
• [Journal Article] Adhesion-mediated self-renewal abilities of Ph+ blastoma cells. (2010)
  • Author(s): Funayama K, Saito-Kurimoto Y, Ebihara Y, Shimane Y, Nomura H, Tsuji K, Asano S
  • Journal Title: Biochem Biophys Res Commun (in press.)
  • Peer Reviewed
• [Journal Article] Generation of blood cells from human ES cells and embryonic hematopoiesis. (2010)
  • Author(s): Ma F, Yang W, Tsuji K
  • Journal Title: J Pedatir Biochem (in press.)
  • Peer Reviewed
• [Journal Article] Application of whole mouse embryo culture system on stem cell research (2009)
  • Author(s): Kulkeaw K, Mizuochi C, Horio Y, Osumi N, Tsuji K, Sugiyama D.
  • Journal Title: Stem Cell Rev & Rep. 5 Pages: 175-180
  • Peer Reviewed
• [Journal Article] ヒトES細胞からの血液細胞の産生 (2009)
  • Author(s): 辻浩一郎
  • Journal Title: 人工血液 17 Pages: 29-36
  • Peer Reviewed
• [Journal Article] iPS細胞からの血液誘導 (2009)
  • Author(s): 辻浩一郎
  • Journal Title: 臨床検査 Pages: 737-743
• [Journal Article] (2009)
  • Author(s): 海老原康博
  • Journal Title: 小児がん. がん患者の心に寄り添うためのサイコオンコロジーの基礎と実践.(大木桃代編)(真興交易医書出版部) Pages: 43-47
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. (2008)
  • Author(s): Mizutani T, Mizutani T, Tsuji K, Ebihara Y, Ohba Y, Taniguchi T, Honda K
  • Journal Title: Exp Hematol 36 Pages: 255-264
  • Peer Reviewed
• [Journal Article] Cardiovascular toxicity of cryopreserved cord blood cell infusion. (2008)
  • Author(s): Konuma T, Konuma T, Ooi J, Takahashi S, Tomonari A, Tsukada N, Kobayashi T, Sato A, Kato S, Kasahara S, Ebihara Y, Nagamura-Inoue T, Tsuji K, Tojo A, Asano S
  • Journal Title: Bone Marrrow Transplant 41 Pages: 861-865
  • Peer Reviewed
• [Journal Article] Direct development of functionally mature tryptase/chymase double positive connective tissue-type mast cells from primate ES cells. (2008)
  • Author(s): Ma F, Kambe N, Wang D, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T
  • Journal Title: Stem Cells 26(3) Pages: 706-714
  • Peer Reviewed
• [Journal Article] Generation of functional erythroid cells from human embryonic stem cell-derived definitive hematopoiesis. (2008)
  • Author(s): Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K
  • Journal Title: Proc Natl Acad Sci USA 105(35) Pages: 13087-13092
  • Peer Reviewed
• [Journal Article] Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis. (2008)
  • Author(s): Ma F et al.
  • Journal Title: Proc Natl Acad Sci USA 105 Pages: 13087-13092
  • Peer Reviewed
• [Journal Article] Direct development of functionally mature tryptase/chymase double positive tissue-type mastc ells from primate ES cells. (2008)
  • Author(s): Ma F et aL
  • Journal Title: Stem Cells 26 Pages: 706-714
  • Peer Reviewed
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. (2008)
  • Author(s): Mizutani T et al.
  • Journal Title: Exp Hematol 36 Pages: 255-264
  • Peer Reviewed
• [Journal Article] Cardiovascular toxidty of cryopreserved cord blood cell infusion. (2008)
  • Author(s): Konuma T et al.
  • Journal Title: Bone Marrrow Transplant 41 Pages: 861-865
  • Peer Reviewed
• [Journal Article] 胎児造血とヒトES細胞からの血液の産生 (2008)
  • Author(s): 辻浩一郎
  • Journal Title: 日本小児科学会雑誌 112 Pages: 1654-1662
  • NAID: 10024842380
• [Journal Article] Application of whole mouse embryo culture system on stem cell research.
  • Author(s): Kulkeaw K et al.
  • Journal Title: Stem Cell Rev & Rep (掲載確定)
  • Peer Reviewed
• [Journal Article] ヒトES細胞からの血液細胞の産生
  • Author(s): 辻浩一郎
  • Journal Title: 人工血液 (掲載確定)
• [Journal Article] iPS細胞からの血液誘導
  • Author(s): 辻浩一郎
  • Journal Title: 臨床検査 (掲載確定)
• [Presentation] ヒトiPS細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来 間葉系幹細胞との共培養 (2011)
  • Author(s): 海老原康博, 他
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京:京王プラザホテル
• [Presentation] ヒトips細胞から血液細胞への動物血清・細胞非依存的分化誘導:自己iPS細胞由来間葉系幹細胞との共培養. (2011)
  • Author(s): 海老原康博, 他
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京京王プラザホテル
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2010)
  • Author(s): 海老原康博, 他
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪:大阪国際会議場
• [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Yang W, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orange County Convention Center, Orlando, Florida, USA
• [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome. (2010)
  • Author(s): Nishihama N, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orange County Convention Center, Orlando, Florida, USA
• [Presentation] Generation of functionally mature blood cells from human ES/iPS cells and their possible clinical utilization. (2010)
  • Author(s): Ma F.
  • Organizer: BIT's 3^<rd> Annual World Congress of RegenerativeMedicine & Stem Cells (RMSC-2010)
  • Place of Presentation: Shanghai Everbright Convention and Exhibition Center Shanghai, China
• [Presentation] Generation of functionally mature blood cells from human pluripotent stem cells. (2010)
  • Author(s): Ma F.
  • Organizer: International Forum on Stem Cells 2010
  • Place of Presentation: Chinese Academy of Medical Sciences Tianjin, China
• [Presentation] The novel transfusion and cellular therapies based on human ES and iPScells. (2010)
  • Author(s): Ma F.
  • Organizer: 5^<th> National Congress of the China Society of Blood Transfusion
  • Place of Presentation: The Century City New International Convention & Exhibition Center, Chengdu, China
• [Presentation] The impact of steroid use as a GVHD treatment or prophylaxis within100 days after CBT. (2010)
  • Author(s): Kawakita T, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 神奈川:パシフィコ横浜
• [Presentation] Acute promyelocytic leukemia with adult Down syndrome : a case report. (2010)
  • Author(s): Tsuda M, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 神奈川:パシフィコ横浜
• [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Ma F, et al.
  • Organizer: 39^<th> Annual Scientific Meeting of ISEH
  • Place of Presentation: Melbourne Convention & Exhibition Centre, Melbourne Australia
• [Presentation] ヒトES細胞から血液細胞への分化誘導 (2010)
  • Author(s): 辻浩一郎
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京:東京慈恵会医科大学
• [Presentation] 慢性骨髄性白血病に対する骨髄破壊的前処置を用いた臍帯血移植 (2010)
  • Author(s): 河北敏郎, 他
  • Organizer: 第32回日本造血細胞移植学会
  • Place of Presentation: 静岡:アクトシティ浜松
• [Presentation] Generation of mature eosinophils from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Ma F, et al.
  • Organizer: 39^<th> Annual Scientific Meeting of ISEH
  • Place of Presentation: Melbourne, Australia
• [Presentation] Hematopoiesis of human induced pluripotent stem cells derived from patients with Down syndrome. (2010)
  • Author(s): Nishihama N, et al.
  • Organizer: 52^<nd> ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] Differentiation of mature eosinophils derived from human embryonic and induced pluripotent stem cells. (2010)
  • Author(s): Yang W, et al.
  • Organizer: 52nd ASH Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] The novel transfusion and cellular therapies based on human ES and iPS cells. (2010)
  • Author(s): Ma F.
  • Organizer: 5^<th> National Congress of the China Society of Blood Transfusion.
  • Place of Presentation: Chengdu, China
• [Presentation] Generation of functionally mature blood cells from human pluripotent stem cells. (2010)
  • Author(s): Ma F.
  • Organizer: International Forum on Stem Cells 2010
  • Place of Presentation: Tianjin, China
• [Presentation] Generation of functionally mature blood cells from human ES/iPS cells and their possible clinical utilization. (2010)
  • Author(s): Ma F.
  • Organizer: BIT's 3^<rd> Annual World Congress of Regenerative Medicine & Stem Cells (RMSC-2010)
  • Place of Presentation: Shanghai, China
• [Presentation] ヒトES細胞から血液細胞への分化誘導 (2010)
  • Author(s): 辻浩一郎
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京慈恵医科大学
• [Presentation] Acute promyelocytic leukemia with adult Down syndrome : a case report. (2010)
  • Author(s): Tsuda M, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜パシスコ横浜
• [Presentation] The impact of steroid use as a GVHD treatment or prophylaxis within 100 days after CBT. (2010)
  • Author(s): Kawakita T, et al.
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜パシスコ横浜
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2010)
  • Author(s): 海老原康博, 他
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 慢性骨髄性白血病に対する骨髄破壊的前処置を用いた臍帯血移植 (2010)
  • Author(s): 河北敏郎, 大井淳, 高橋聡, 塚田信弘, 加藤せい子, 佐藤亜紀, 永田泰之, 海老原康博, 辻浩一郎, 浅野茂隆, 東條有伸
  • Organizer: 第32回日本造血細胞移植学会
  • Place of Presentation: 浜松
• [Presentation] Regenerative medicine and hematopoietic stem cells. (2009)
  • Author(s): 辻浩一郎
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: 中国医科学研究院/天津血液研究所病院 Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Regenerative medicine and hematopoietic stem cells. (2009)
  • Author(s): Tsuji K.(Invited Speaker)
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] Regenerative medicine based on human ES/iPS cells. (2009)
  • Author(s): Ma F
  • Organizer: Educational Symposium for Current Pediatric Hematology
  • Place of Presentation: Tianjin, China
  • Year and Date: 2009-09-18
• [Presentation] ヒトES細胞維持機能を有するヒトES細胞由来ストローマ細胞 (2009)
  • Author(s): 海老原康博, 他
  • Organizer: 第8回日本再生医療学会
  • Place of Presentation: 東京:東京国際フォーラム
  • Year and Date: 2009-03-05
• [Presentation] ヒトES細胞維持能を有するヒトES細胞由来ストローマ細胞 (2009)
  • Author(s): 海老原康博他
  • Organizer: 第8回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] 15-20歳の思春期奨励に対する臍帯血移植の検討 (2009)
  • Author(s): 海老原康博, 他
  • Place of Presentation: 北海道:ロイトン札幌
  • Year and Date: 2009-02-05
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2009)
  • Author(s): 海老原康博他
  • Organizer: 第31回日本造血細胞移植学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-02-05
• [Presentation] 再発・難治性白血病4例に対するIDA-FLAG療法の効果および有効性 (2009)
  • Author(s): 渡辺温子, 他
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 千葉:東京ベイホテル東急
• [Presentation] Second or third myeloablative allo-SCT using cord blood for adult leukemia. (2009)
  • Author(s): Kato S, et al
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都:国立京都国際会館
• [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions. (2009)
  • Author(s): Ebihara Y, et al
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都:国立京都国際会館
• [Presentation] Derivation of mature blood cells from human induced pluripotent stem cells. (2009)
  • Author(s): Ma F, et al
  • Organizer: 38th Annual Scientific Meeting of the International Society of Experimental Hematology
  • Place of Presentation: Horel Divani Caravel, Athens, Greece
• [Presentation] Human embryonic stem (ES) cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions. (2009)
  • Author(s): Ebihara Y, et al
  • Organizer: 7th Annual Meeting of the International Society of Stem Cell Research
  • Place of Presentation: Centre convencions Internacional, Barcelona, Spain
• [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells. (2009)
  • Author(s): Ma F, et al
  • Organizer: 7th Keio Stem Cell Research Symposium
  • Place of Presentation: 東京:慶応義塾大学
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2009)
  • Author(s): 海老原康博, 他
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良:奈良県文化会館
• [Presentation] Human embryonic stem(ES)cell-derived mesenchymal stem cells capable of efficiently maintaining human ES and induced pluripotent stem cells under animal serum-free conditions (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, Ononda H, Oyaizu N.
  • Organizer: 7th Annual Meeting of the International Society of Stem Cell Research
  • Place of Presentation: Barcelona, Spain
• [Presentation] Derivation of mature blood cells from humam induced pluripotent stem cells. (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 38th Annual Scientific Meeting of the International Society of Experimental Hematology
  • Place of Presentation: Athens, Greece
• [Presentation] Derivation of multipotential hematopoietic progenitors and mature blood cells from human induced pluripotent stem cells. (2009)
  • Author(s): Ma F, Ebihara Y, Nakauchi H, Tsuji K.
  • Organizer: 7th Keio Stem Cell Research Symposium
  • Place of Presentation: Tokyo, Japan
• [Presentation] Second or third myeloblative allo-SCT using cord blood for adult leukemia. (2009)
  • Author(s): Kato S, Ooi J, Tahashi S, Tsukada N, Sato A, Konuma T, Kawakita T, Nagata Y, Ebihara Y Tsuji K, Tojo A, Asano S.
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] Human ES cell-derived MSC maintining human ES and iPS cells under animal serum-free conditions. (2009)
  • Author(s): Ebihara Y, Ma F, Hanada S, Tomizawa D, Tsuji K, Oyaizu N.
  • Organizer: 第71回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 15-20歳の思春期症例に対する臍帯血移植の検討 (2009)
  • Author(s): 海老原康博, 辻浩一郎
  • Organizer: 第112回日本小児科学会学術集会
  • Place of Presentation: 奈良
• [Presentation] 再発・難治性白血病4例に対するIDA-FLAG療法の効果および有効性 (2009)
  • Author(s): 渡辺温子, 田中竜平, 正田絵里子, 水野圭子, 森脇浩一, 海老原康博
  • Organizer: 第51回日本小児血液学会
  • Place of Presentation: 舞浜
• [Presentation] Myelodysplastic Syndrome (MDS) and Myeloproliferative Disease (MPD) in Children : A prospective Resistration of 222 Cases. (2008)
  • Author(s): Hirabayashi S, et al.
  • Organizer: 15th annual meeting of American Society of Hematology
  • Place of Presentation: Moscone Convention Center, San Francisco, USA
  • Year and Date: 2008-12-07
• [Presentation] Myelodysplastic Syndrome(MDS)and Myeloproliferative Disease(MPD)in Chidren: A prospective Resistration of 222 Cases. (2008)
  • Author(s): Hirabayashi S et a1.
  • Organizer: 15th annual meeting of American Society of Hematology
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-07
• [Presentation] 異種動物血清を用いないヒトembryonic stem cell(hESC)から間葉系幹細胞(MSC)への分化誘導 (2008)
  • Author(s): 海老原康博, 他
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都:国立京都国際会館
  • Year and Date: 2008-10-10
• [Presentation] 異種動物血清を用いないヒトembryonic stem cell(hESC)から間葉系幹細胞(MSC)への分化 (2008)
  • Author(s): 海老原康博他
  • Organizer: 第70回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-10
• [Book] Stem Cell Therapy (2011)
  • Author(s): Ma F, Yang W, Tsuji K
  • Publisher: Transworld Research Network, Kerala,
• [Book] Embryonic stem cells (2011)
  • Author(s): Ma F, Ebihara Y, Tsuji K
  • Publisher: Intech, Vienna(掲載確定)
• [Book] Lineage-specific differentiation of human embryonic and induced pluripotent stem cells methods and protocols (2011)
  • Author(s): Ma F, Gu Y, Nishihama N, Ebihara Y, Tsuji K
  • Publisher: Humana Press, New York(掲載確定)
• [Book] 臍帯血移植の基礎と臨床 (2011)
  • Author(s): 辻浩一郎
  • Publisher: 医学書院(東京)(掲載確定)
• [Book] Stem Cell Therapy (2011)
  • Author(s): Ma F, et al.
  • Publisher: Transworld Research Network, Kerala
• [Book] Embryonic stem cells (2011)
  • Author(s): Ma F, et al.
  • Publisher: Intech, Vienna(in press刊行確定)
• [Book] Lineage-specific differentiation of human embryonic and induced pluripotent stem cells methods and protocols (2011)
  • Author(s): Ma F, et al.
  • Publisher: Humana Press, New York(刊行確定)
• [Book] 臍帯血移植の基礎と臨床 (2011)
  • Author(s): 辻浩一郎
  • Publisher: 医学書院(東京)(印刷中 刊行確定)
• [Book] Regenerative medicine based on human ES and iPS cells. (2010)
  • Author(s): Ma F, Yang W, Tsuji K.
  • Publisher: Stem cells in medicine. edited by Isobe K(Transworld Research Network, Kerala)(in press)
• [Book] 胎生期の造血.臍帯血移植の基礎と臨床(浅野茂隆、谷口克編) (2010)
  • Author(s): 辻浩一郎
  • Publisher: 医学書院(東京)(印刷中)
• [Book] 医学書院(東京) (2010)
  • Author(s): 辻浩一郎
  • Publisher: Myelodysplastic symdrome.今日の小児治療指針、大関武彦、古川漸、横田俊一郎、水口雅編(印刷中)
• [Remarks] ホームページ等
• [Remarks] 東京大学医科学研究所 幹細胞治療研究センター 幹細胞プロセシング分野
  • URL: http://stemcell-u.tokyo.org/scp/
• [Remarks] 東京大学医科学研究所 幹細胞治療研究モンター 幹細胞プロセシング分野
  • URL: http://stemcell-u-tokyo.org/scp/
• [Remarks]
  • URL: http://stemcell-u-tokyo.org/scp/
• [Remarks] A-IBMN Rearch(by Asian-Pacific International Molecular Biology Network)Highlights:"Turning stem cells into Blood", on 17 December 2008.
  • URL: http://www.natureasia.com/A-IMBN/article.php?id=168
• [Patent(Industrial Property Rights)] Method for producing eosinophils from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-12-03
• [Patent(Industrial Property Rights)] ヒト由来の多能性幹細胞を分化させる方法 (2010)
  • Inventor(s): 辻浩一郎、海老原康博
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 2010-222583
  • Filing Date: 2010-09-30
• [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] Method for producing mast cells from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-09-08
• [Patent(Industrial Property Rights)] Method for producing eosinophils from pluripotent stem cells (2010)
  • Inventor(s): 辻浩一郎、馬峰、斎藤博久、松本健治、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2010-12-03
  • Overseas
• [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法 (2009)
  • Inventor(s): 辻浩一郎、馬峰、中畑龍俊
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2009-09-08
• [Patent(Industrial Property Rights)] 多能性幹細胞からの肥満細胞の製造方法 (2009)
  • Inventor(s): 辻浩一郎, 馬峰, 中畑龍俊
  • Industrial Property Rights Holder: 国立大学法人 京都大学
  • Filing Date: 2009-09-08
  • Overseas