Structural and functional analyses of the mirror neuron system and their application to early diagnosis in schizophrenia
| Project/Area Number |
20591393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
SUZUKI Michio 富山大学, 大学院・医学薬学研究部(医学), 教授 (40236013)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASKI Yasuhiro 富山大学, 附属病院, 講師 (80242519)
SUMIYOSHI Tomiki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (80286062)
NAKAMURA Kazue 富山大学, 附属病院, 助教 (00447658)
KURACHI Masayoshi 富山大学, 大学院・医学薬学研究部(医学), 名誉教授 (80019603)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 精神生理学 / 統合失調症 / 機能的磁気共鳴画像 / ミラーニューロンシステム / 社会脳 / 自己 / 他者 / 自己意識 / 拡散テンソル画像 / fractional anisotropy / 陰性症状 |
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| Research Abstract |
A diffusion tensor imaging(DTI) study revealed disturbed white matter integrity in bundles connecting the frontal lobe with the thalamus and temporal lobe, a part of which is suggested to implicate the negative symptoms in schizophrenia. A functional magnetic resonance imaging(fMRI) study using self-and other-evaluation tasks demonstrated functional abnormalities in the prefrontal cortex, cerebral midline stuructures, and inferior parietal lobule, which provide evidence for neural basis of deficits in self-awareness in schizophrenia. A structural MRI study in patients with early phase of psychosis suggested the implication of the anterior cingulate cortex in manifestation of overt psychosis in schizophrenia.
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Report
(6 results)
Research Products
(58 results)
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[Journal Article] Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia. Prog2011
Author(s)
Takahashi T., Zhou S. Y., Nakamura K., Tanino R., Furuichi A., Kido M., Kawasaki Y., Noguchi K., Seto H., Kurachi M., and Suzuki M.
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Journal Title
Neuropsychopharmacol. Biol. Psychiatry
Volume: 35
Pages: 177-183
Related Report
Peer Reviewed
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[Journal Article] A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum. Prog2011
Author(s)
Takahashi T., Zhou S. Y., Nakamura K., Tanino R., Furuichi A., Kido M., Kawasaki Y., Noguchi K., Seto H., Kurachi M., and Suzuki M.
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Journal Title
Neuropsychopharmacol. Biol. Psychiatry
Volume: 35
Pages: 1957-1964
Related Report
Peer Reviewed
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[Journal Article] Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness2011
Author(s)
Takayanagi Y., Takahashi T., Orikabe L., Mozue Y., Kawasaki Y., Nakamura K., Sato Y., Itokawa M., Yamasue H., Kasai K., Kurachi M., Okazaki Y., and Suzuki M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables. Prog2010
Author(s)
Takayanagi Y., Kawasaki Y., Nakamura K., Takahashi T., Orikabe L., Toyoda E., Mozue Y., Sato Y., Itokawa I., Yamasue H., Kasai K., Kurachi M., Okazaki Y., Matsushita M., Suzuki M.
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Journal Title
Neuropsychopharmacol. Biol. Psychiatry
Volume: 34
Pages: 10-17
Related Report
Peer Reviewed
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[Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia2010
Author(s)
Takayanagi Y., Takahashi T., Orikabe L., Masuda N., Mozue Y., Nakamura K., Kawasaki Y., Itokawa M., Sato Y., Yamasue H., Kasai K., Okazaki Y., Suzuki M.
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Journal Title
Schizophr. Res
Volume: 121
Pages: 55-65
Related Report
Peer Reviewed
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