Neuroimaging study to predict clinical response of obsessive-compulsive disorder by using 3-Tesla proton MRS and multichannel NIRS

• Project/Area Number: 20591410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokushima
• Principal Investigator: SUMITANI Satsuki 徳島大学, 大学院・ヘルスバイオサイエンス研究部・精神医学分野, 准教授 (90346594)
• Co-Investigator(Kenkyū-buntansha): HARADA Masafumi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20228654) ; TAYOSHI Shinya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (90403724)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 強迫性障害 / NIRS MRS SSRI / 薬物応答性 / 脳血流 / 非定型抗精神病薬 / NAA / MRS / NIRS / SSRI / 非定型抗精神病

Research Abstract

We studied to find predictors of clinical response of obsessive-compulsive disorder by using 3-Tesla proton magnetic resonance spectroscopy(MRS) and multichannel near-infrared spectroscopy(NIRS). Significantly lower insight levels and earlier onset were observed in responders to SSRI with atypical antipsychotic. Obsessive-compulsive disorder patients showed higher level of NAA/ Cr in right basal ganglia by using 3-Tesla proton MRS and hypofrontality by using multichannel NIRS compared to control group.

Research Products

• [Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia (2011)
  • Author(s): Ueoka Y, Tomotake M, Tanaka T, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S, Ohmori T, Ueno S, Ohmori T
  • Journal Title: Progress in psychopharmacology and biological psychiatry Volume: 35(1) Pages: 53-59
  • Peer Reviewed
• [Journal Article] Non-Invasive Evaluation of the GABAergic/ Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument (2011)
  • Author(s): Harada M, Taki M M, Nose A, Kubo H, Mori K, Hiromu Nishitani, Tsuyoshi Matsuda
  • Journal Title: J Autism Dev Dis Volume: 41(4) Pages: 447-55
  • Peer Reviewed
• [Journal Article] Measurement of Variation in the Human Cerebral GABA Level by in vivo MEGA-Editing Proton MR Spectroscopy using a Clinical 3 Tesla Instrument and its Dependence on Brain Region and the Female Menstrual Cycle (2011)
  • Author(s): Harada M, Kubo H, Nose A, Nishitani H, Matsuda T
  • Journal Title: Human Brain Mapping Volume: 32(5) Pages: 858-33
  • Peer Reviewed
• [Journal Article] GABA concentration in schizophrenia patients and the effects of antipsychotic medication : A proton magnetic resonance spectroscopy study (2010)
  • Author(s): Tayoshi S, Nakataki M, Sumitani S, Taniguchi K, Shibuya-Tayoshi S, Numata S, Iga J, Ueno S, Harada M, Ohmori T
  • Journal Title: Schizophr Res Volume: 117(1) Pages: 83-91
  • Peer Reviewed
• [Journal Article] Quality of life and cognitive dysfunction in people with schizophrenia (2010)
  • Author(s): Y.Ueoka
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(1) Pages: 53-59
  • Peer Reviewed
• [Journal Article] Restless legs syndrome with chest and back restlessness as the initial syndrome (2010)
  • Author(s): H.Umehara
  • Journal Title: Psychiatry Clin Neurosci Volume: 64(2) Pages: 211-211
  • Peer Reviewed
• [Journal Article] GABA concentration in schizophrenia patients and the effects of antipsychotic medication : A proton magnetic resonance spectroscopy study. (2010)
  • Author(s): S.Tayoshi
  • Journal Title: Schizophr Res. 117 Pages: 83-91
  • Peer Reviewed
• [Journal Article] Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy(1H-MRS) (2009)
  • Author(s): Tayoshi S, Sumitani S, Taniguchi K, Shibuya-Tayoshi S, Numata S, Iga J, Nakataki M, Ueno S, Harada M, Ohmori T
  • Journal Title: Schizophr Res Volume: 108 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Gene suppression and association analysis of the phosphodiesterase 4B(PDE4B) gene in major depressive disorder in the Japanese population (2009)
  • Author(s): Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 150(4) Pages: 527-534
  • Peer Reviewed
• [Journal Article] NIRS研究と臨床への応用 (2009)
  • Author(s): 住谷さつき
  • Journal Title: 脳と精神の医学 Volume: 20(3) Pages: 163-169
  • NAID: 10028262102
• [Journal Article] 強迫性障害の現在とこれからOCDの病態:神経化学的側面を中心に (2009)
  • Author(s): 住谷さつき
  • Journal Title: 精神神経学雑誌 Volume: 111(7) Pages: 796-801
• [Journal Article] 多チャンネル近赤外線スペクトロスコピーを用いた強迫性障害の前頭葉機能の検討 (2009)
  • Author(s): 住谷さつき, 宮田幸奈, 秋山麻衣, 谷口京子, 大森哲郎
  • Journal Title: 強迫性障害の研究10 Pages: 41-48
• [Journal Article] Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (2009)
  • Author(s): S.Numata
  • Journal Title: Am J Med Genet 150 Pages: 527-534
  • Peer Reviewed
• [Journal Article] OCDの病態:神経化学的側面を中心に (2009)
  • Author(s): 住谷さつき
  • Journal Title: 精神神経学雑誌 111 Pages: 796-801
  • NAID: 10026307520
• [Journal Article] NIRS研究と臨床への応用 (2009)
  • Author(s): 住谷さつき
  • Journal Title: 脳と精神の医学 20(3)163-169,2009 163 Pages: 163-169
  • NAID: 10028262102
• [Journal Article] 多チャンネル近赤外線スペクトロスコピーを用いた強迫性障害の前頭葉機能の検討 (2009)
  • Author(s): 住谷さつき
  • Journal Title: 強迫性障害の研究 10 Pages: 41-48
• [Journal Article] Gene expression and association analyses of the PDE4B (Phosphodiesterase 4B) gene in major depressive disorder in the Japanese Population. (2009)
  • Author(s): S. Numata
  • Journal Title: Am J Med Genet. (印刷中)
  • Peer Reviewed
• [Journal Article] MRS精神疾患の脳画像解析・診断学 (2008)
  • Author(s): 住谷さつき, 原田雅史
  • Pages: 30-36
• [Journal Article] Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (IH-MRS) (2008)
  • Author(s): S. Tayoshi
  • Journal Title: Schizophrenia Research 108 Pages: 69-77
  • Peer Reviewed
• [Journal Article] Positive Association of The PDE4B (Phosphodiesterase 4B) gene with Schizop hrenia in the Japanese Population. (2008)
  • Author(s): S. Numata
  • Journal Title: J Psychiatric Res 43 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Predictors of subjective and objective quality of life in outpatients with schizophrenia (2008)
  • Author(s): Ken Yamauchi
  • Journal Title: Psychiatry Clin Neurosci 62 Pages: 404-411
  • Peer Reviewed
• [Journal Article] 多彩な経過後発症16年目に躁状態を呈し初めて双極性障害と診断された1症例 (2008)
  • Author(s): 住谷さっき
  • Journal Title: Bipolar Disorder 6 Pages: 26-31
• [Journal Article] OCDの薬物応答性と臨床特徴について (2008)
  • Author(s): 住谷さっき
  • Journal Title: 強迫性障害の研究 9 Pages: 105-113
• [Presentation] 高磁場MRSを用いた非侵襲的脳内代謝物質測定による統合失調症アミノ酸仮説の検討 (2011)
  • Author(s): 住谷さつき, 田吉伸哉, 中瀧理仁, 大森哲郎
  • Organizer: 第7回統合失調症研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-05
• [Presentation] Tetsuro Ohmori Relationship between the level of difficulty of task and hemodynamic change measured by NIRS (2011)
  • Author(s): Satsuki Sumitani, Yusuke Uenishi, Shuhei Watanabe, Yukina Watanabe, Mai Akiyama
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague
• [Presentation] 選択性緘黙の15歳女児との心理療法過程-筆談によるコミュニケーションを通して- (2010)
  • Author(s): 秋山麻衣
  • Organizer: 第51回日本児童青年精神医学会
  • Place of Presentation: 前橋
  • Year and Date: 2010-10-30
• [Presentation] 近赤外線スペクトロスコピーを用いた課題の難易度と前頭葉血流変化の関連 (2010)
  • Author(s): 住谷さつき, 上西優介, 渡邊周平, 渡部幸奈, 秋山麻衣, 大森哲郎
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-07
• [Presentation] 近赤外性スペクトロスコピーを用いた課題の難易度と前頭葉血流変化の関連 (2010)
  • Author(s): 住谷さつき
  • Organizer: 第32回日本生物学性精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-07
• [Presentation] Clinical features in patients with obsessive-compulsive disorder with different pharmacological response (2010)
  • Author(s): S.Sumitani
  • Organizer: XXVII CINP Congress
  • Place of Presentation: Hong Kong
  • Year and Date: 2010-06-10
• [Presentation] シンポジウム強迫性障害治療の現況今後OCDの薬物療法の現況と今後 (2010)
  • Author(s): 住谷さつき
  • Organizer: 日本不安障害学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-07
• [Presentation] OCDの薬物療法の現況と今後 (2010)
  • Author(s): 住谷さつき
  • Organizer: 第2回日本不安障害学会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-03-07
• [Presentation] Tetsuro Ohmori Clinical features in patients with obsessive-compulsive disorder with different pharmacological response (2010)
  • Author(s): Satsuki Sumitani
  • Organizer: XXV2 CINP Congress
  • Place of Presentation: Hong Kong
• [Presentation] 多チャンネルNIRSを用いた表情刺激に対する快不快判断と性別判断の前頭葉血流変化の比較 (2009)
  • Author(s): 飯塚優子
  • Organizer: 第50回中国四国精神神経学会
  • Place of Presentation: 松江市
  • Year and Date: 2009-11-26
• [Presentation] 強迫性障害の薬物応答性と臨床特徴について (2009)
  • Author(s): 住谷さつき, 大森哲郎
  • Organizer: 第31回臨床精神薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-14
• [Presentation] 強迫性障害の薬物応答性と臨床特徴について (2009)
  • Author(s): 住谷さつき
  • Organizer: 第31回臨床精神薬理学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-11-14
• [Presentation] 徳島大学病院における成人PDD診断の現状について (2009)
  • Author(s): 住谷さつき
  • Organizer: 第29回日本精神科診断学会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2009-10-17
• [Presentation] 3Tproton MRSを用いた強迫性障害の基底核における代謝物質の左右差の検討 (2009)
  • Author(s): 住谷さつき, 原田雅史, 久保均, 田吉伸哉, 大森哲郎
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] 3T proton MRSを用いた強迫性障害の基底核における代謝物質の左右差の検討 (2009)
  • Author(s): 住谷さつき
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都市
  • Year and Date: 2009-04-25
• [Presentation] 多チャンネル近赤外線スペクトロスコピーを用いた強迫性障害の認知機能の検討 (2008)
  • Author(s): 住谷さっき
  • Organizer: 第10回OCD研究会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-29
• [Presentation] 多チャンネル近赤外線スペクトロスコピーを用いた強迫性障害の認知機能の検討 (2008)
  • Author(s): 住谷さっき
  • Organizer: 第30回日本生物学的精神医学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] 心因性嘔吐にSSRIが奏功した二症例 (2008)
  • Author(s): 住谷さっき
  • Organizer: 第49回日本心身医学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-06-12
• [Presentation] シンポジウム強迫性障害の現在とこれからOCDの病態 : 神経化学的側面を中心に (2008)
  • Author(s): 住谷さっき
  • Organizer: 第104回日本精神神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Book] よくわかる精神科治療薬の考え方、使い方7. 神経症性、ストレス関連性障害および身体表現障害 (2008)
  • Author(s): 住谷さっき
  • Publisher: 中外医薬社
• [Book] 精神疾患の脳画像解析・診断学I-A-4. MRS (2008)
  • Author(s): 住谷さっき
  • Publisher: 南山堂
• [Book] 専門医のための精神科臨床リュミエール6双極性障害III-4 安障害、強迫性障害、摂食障害とのコモビディティ (2008)
  • Author(s): 住谷さっき
  • Publisher: 中山書店