The neural substrate of stereotypic behaviors in patients with frontotemporal dementia
Project/Area Number |
20591414
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kumamoto University |
Principal Investigator |
IKEDA Manabu Kumamoto University, 大学院・生命科学研究部, 教授 (60284395)
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Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Mamoru 熊本大学, 医学部附属病院, 助教 (20452881)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 常同行動 / FTD / 神経基盤 / 統計画像解析 / SPECT / 食行動 / Semantic Dementia / Progressive supranuclear palsy / Semantic dementia |
Research Abstract |
Recently, the relationship between Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features. However, there have been few studies that directly compared neuropsychiatric symptoms between PSP and FTD. The aim of the present study was to investigate comprehensive psychiatric and behavioral symptoms in PSP and compared them with those in FTD. Patients with PSP (n=10) and FTD (n=13) were selected on the basis of inclusion/exclusion criteria from a consecutive series in the dementia clinic of Kumamoto University Hospital. We assessed their comprehensive neuropsychiatric features by using the Neuropsychiatric Inventory (NPI), the Stereotypy Rating Inventory (SRI) and a specific antisocial behavior checklist. There were no significant differences in the total NPI and NPI subscale scores between the two groups. Both groups showed quite asimilar pattern in the features of neuropsychiatric symptoms : apathy showed the highest score, followed by aberrant motor behavior and disinhibition. The PSP group was significantly lower in the total SRI and eating and cooking behavior scores than those in the FTD group. The prevalence of antisocial behaviors in PSP (50%) was equal to those in the FTD group (46%). We hypothesize that the stereotypic behaviors reflect the involvement of specific neural substrate in FTD-namely, the ventral frontal lobe, the temporal pole, and the amygdala.
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Report
(4 results)
Research Products
(103 results)
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[Journal Article] Clinical profiles of Late-onset Semantic Dementia, compared with Early-onset Semantic Dementia and Late-onset Alzheimer's Disease.2011
Author(s)
Shimizu H, Komori K, Fukuhara R, Shinagawa S, Toyota Y, Kashibayashi T, Sonobe N, Matsumoto T, Mori T, Ishikawa T, Hokoishi K, Tanimukai S, Ueno S, Ikeda M.
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Journal Title
Psychogeriatrics 11
Pages: 46-53
NAID
Related Report
Peer Reviewed
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[Journal Article] Risk of progression from mild memory impairment to clinically diagnosable Alzheimer disease in a Japanese community (from the Nakayama Study).2011
Author(s)
Sonobe N, Hata R, Ishikawa T, Sonobe K, Matsumoto T, Toyota Y, Mori T, Fukuhara R, Komori K, Ueno S, Tanimukai S, Ikeda M.
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Journal Title
International Psychogeriatrics 23
Pages: 772-779
Related Report
Peer Reviewed
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[Journal Article] Clinical profiles of Late-onset Semantic Dementia, compared with Early-onset Semantic Dementia and Late-onset Alzheimer's Disease2011
Author(s)
Shimizu H, Komori K, Fukuhara R, Shinagawa S, Toyota Y, Kashibayashi T, Sonobe N, Matsumoto T, Mori T, Ishikawa T, Hokoishi K, Tanimukai S, Ueno S, Ikeda M
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Journal Title
Psychogeriatrics
Volume: 11
Pages: 46-53
NAID
Related Report
Peer Reviewed
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[Journal Article] 認知症に伴う行動・心理症状(BPSD)への医療介入に関する実態調査2011
Author(s)
中野正剛, 宮村季浩, 平井茂夫, 大澤誠, 川嶋乃里子, 川畑信也, 高桑光俊, 高瀬義昌, 田北昌史, 楢林洋介, 八森淳, 平原佐斗司, 池田恵理子, 元永拓郎, 安田朝子, 木之下徹, 朝田隆, 池田学, 小阪憲司
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Journal Title
日本老年精神医学雑誌
Volume: 22
Pages: 313-324
Related Report
Peer Reviewed
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[Journal Article] Transition of distinctive symptoms of semantic dementia during longitudinal clinical observation.2010
Author(s)
Kashibayashi T, Ikeda M., Komori K, Shinagawa S, Shimizu H, Toyota Y, Mori T, Ishikawa T, Fukuhara R, Ueno S, Tanimukai S.
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Journal Title
Dement Geriatr Cogn Disord 29
Pages: 224-232
Related Report
Peer Reviewed
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[Journal Article] Transition of distinctive symptoms of semantic dementia during longitudinal clinical observation2010
Author(s)
Kashibayashi T, Ikeda M, Komori K, Shinagawa S, Shimizu H, Toyota Y, Mori T, Ishikawa T, Fukuhara R, Ueno S, Tanimukai S
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Journal Title
Dement Geriatr Cogn Disord
Volume: 29
Pages: 224-232
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
池田学
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Journal Title
専門医のための精神科臨床リュミエール12 前頭側頭型認知症の臨床(中山書店)
Pages: 57-63
Related Report
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[Journal Article]2010
Author(s)
池田学
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Journal Title
専門医のための精神科臨床リュミエール12 前頭側頭型認知症の臨床(中山書店)
Pages: 146-153
Related Report
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[Journal Article]2010
Author(s)
池田学
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Journal Title
今日の治療指針2010年版-私はこう治療している(医学書院)
Pages: 787-788
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[Journal Article]2009
Author(s)
橋本衛, 池田学
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Journal Title
専門医のための精神科臨床リュミエール10 注意障害(中山書店)
Pages: 139-150
Related Report
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[Journal Article]2009
Author(s)
池田学
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Journal Title
老年医学の基礎と臨床II 認知症学とマネジメント(ワールドプランニング)
Pages: 300-309
Related Report
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[Journal Article] Risk of progression from mild memory impairment to clinically diagnosable Alzheimer disease in a Japanese community(from the Nakayama Study)
Author(s)
Sonobe N, Hata R, Ishikawa T, Sonobe K, Matsumoto T, Toyota Y, Mori T, Fukuhara R., Komori K, Ueno S, Tanimukai S, Ikeda M
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Journal Title
International Psychogeriatrics
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] Distinction of inferior temporal atrophy in semantic dementia and Alzheimer's disease by MRI visual inspection.2010
Author(s)
Fukuhara R, Mori T, Tanimukai S, Komori K, Matsumoto T, Toyota Y, Kashibayashi T, Shimizu H, Sonobe N, Kitamura I, Ueno S, Ikeda M.
Organizer
7^<th> International Conference on Frontotemporal Dementias
Place of Presentation
Indianapolis, USA
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[Presentation] Transition of distinctive symptoms of semantic dementia during longitudinal clinical observation.2009
Author(s)
Kashibayashi T, Ikeda M, Komori K, Shinagawa S, Shimizu H, Toyota Y, Mori T, Ishikawa T, Fukuhara R, Ueno S, Tanimukai S.
Organizer
IPA 14^<th> International congress
Place of Presentation
Montreal
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