| Project/Area Number |
20591430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TERAE Satoshi Hokkaido University, 病院, 准教授 (40240634)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Takeshi 北海道大学, 病院, 講師 (70250438)
NAKAGAWA Shin 北海道大学, 病院, 講師 (60360905)
KUDO Kohsuke 岩手医科大学, 先端科学技術研究センター, 講師 (10374232)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | MRI / うつ病 / 拡散テンソル |
|---|
| Research Abstract |
Diffusion tensor imaging (DTI) was conducted in 13 treatment-resistant, 12 nontreatment-resistant, and 19 drug-naive patients with major depression. As compared with normal control subjects, a voxel-based analysis revealed significant decrease in fractional anisotropy (FA) in the right frontal white matter in the treatment-resistant patients. Histogram analysis demonstrated significant decrease in peak position of FA histogram of the drug-naive patients. No significant correlation was observed between the FA abnormality and clinical severity as assessed by HDRS, GAF, and MADRS.
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