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The development of the noninvasive diagnostic method of the articular cartilage grafting with 3- tesla magnetic resonance imaging.

Research Project

Project/Area Number 20591443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

FUJII Mashiko  Kobe University, 大学院・医学研究科, 准教授 (00228959)

Co-Investigator(Kenkyū-buntansha) KURODA Ryousuke  神戸大学, 医学部附属病院, 講師 (80379362)
SUGIMURA Kazuro  神戸大学, 大学院・医学研究科, 教授 (00136384)
TAKENAKA Daisuke  神戸大学, 大学院・医学研究科, 講師 (60258233)
OHNO Yoshiharu  神戸大学, 大学院・医学研究科, 学術推進研究員 (30324924)
IWAMA Yuki  神戸大学, 医学部附属病院, 助教 (20457097)
KONISHI Junya  神戸大学, 大学院・医学研究科, 助教 (40403290)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords放射線 / 再生医学 / 病理学 / 関節軟骨 / 3T-MRI / T1ρ / T2 mapping
Research Abstract

The histopathological findings of articular cartilage were compared with T2W images and T2 values in T2 mapping using 3T-MRI. As a result, it was considered that the increase of degenerative collagen was associated with the prolongation of T2 value. The deep layer and calcified layer of articular cartilage cannot be depicted by the conventional sequence because T2 values of these layers are too short. To depict these layers selectively, we developed an ultra short TE (μTE) sequence by cooperation of Hitachi Medico Co., Ltd. These layers were depicted as a hyperintense area by using μTE sequence. To evaluate the decrease of the cartilage matrix with the aging, the T1 ρ value of articular cartilage was measured in healthy volunteers. A strong positive relationship was recognized between an age and the T1 ρ values. It was considered that these data could be used as the normal database which evaluated a change with the aging of the cartilage matrix.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] T2マッピングによる関節軟骨の変性の評価-病理組織所見との対比-2011

    • Author(s)
      岩間祐基、久保晴司、藤井正彦、後藤一、黒田良祐、黒坂昌弘、杉村和朗
    • Journal Title

      関節外科 30

      Pages: 650-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【関節の画像診断の新たな展開】膝関節診断の話題2010

    • Author(s)
      藤井正彦、岩間祐基、後藤一、黒田良祐, 久保晴司, 杉村和朗
    • Journal Title

      臨床画像 26

      Pages: 1250-1263

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【関節の画像診断の新たな展開】膝関節診断の話題2010

    • Author(s)
      藤井正彦、岩間祐基、後藤一, 他
    • Journal Title

      臨床画像

      Volume: 26 Pages: 1250-1263

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 関節軟骨の3T MRI2009

    • Author(s)
      藤井正彦, 岩間祐基, 青山信和, 川光秀昭, 黒田良祐, 杉村和朗
    • Journal Title

      日本磁気共鳴医学会雑誌 29

      Pages: 53-67

    • NAID

      10026287433

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3T MRIによる関節軟骨の描出:軟骨修復の評価法-関節軟骨の修復治療と3T MRI2009

    • Author(s)
      藤井正彦, 岩間祐基, 後藤一, 青山信和, 川光秀昭, 黒田祐介, 黒坂昌弘, 杉村和朗
    • Journal Title

      臨床放射線 54

      Pages: 277-286

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【骨・関節MRIの最前線】撮像と読影のポイント 手・肘関節2009

    • Author(s)
      藤井正彦, 岩間祐基, 後藤一, 青山宿和, 川光秀昭, 牧野健, 黒坂昌弘, 杉村和朗
    • Journal Title

      日本磁気共鳴医学会雑誌 29

      Pages: 133-145

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 3T MRIによる関節軟骨の描出 軟骨修復の評価法 : 関節軟骨の修復治療と3T MRI2009

    • Author(s)
      藤井正彦, 岩間祐基, 黒田良祐ほか
    • Journal Title

      臨床放射線 54

      Pages: 277-286

    • Related Report
      2008 Annual Research Report
  • [Journal Article] MR Iでなにがどこまでわかるか-2008年の現状-骨関節2008

    • Author(s)
      藤井正彦, 岩間祐基, 黒田良祐ほか
    • Journal Title

      臨床画像 2 4

      Pages: 1481-1490

    • Related Report
      2008 Annual Research Report
  • [Presentation] Age related change and weight-bearing related change in the T1 rho value of normal knee cartilage using 3T-MRI : a preliminary study.2011

    • Author(s)
      後藤一, 藤井正彦, 岩間祐基, et al
    • Organizer
      ECR (European Congress of Radiology)2011
    • Place of Presentation
      ウイーン
    • Related Report
      2010 Final Research Report
  • [Presentation] Age related change and weight-bearing related change in the T1 rhovalue of normal knee cartilage using 3T-MRI : a preliminary study2011

    • Author(s)
      Hajimu Goto, Masahiko Fujii, Yuki Iwama, et.al
    • Organizer
      ECR(European Congress of Radiology)2011
    • Place of Presentation
      Austria Center Vienna(Austria)
    • Related Report
      2010 Annual Research Report
  • [Presentation] T2マッピングによる関節軟骨の変性の評価 病理組織所見との対比2010

    • Author(s)
      岩間祐基, 藤井正彦, 後藤一, 青山信和, 川光秀昭, 杉村和朗, 久保晴司, 黒田良祐, 黒坂昌弘
    • Organizer
      第69回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-04-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 超短TE(μTE)シークエンスを用いた関節軟骨の描出2010

    • Author(s)
      後藤一, 藤井正彦, 岩間祐基, 青山信和, 川光秀昭, 大野良治, 瀧澤将宏, 小原陽子, 加藤和之, 杉村和朗
    • Organizer
      第69回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-04-10
    • Related Report
      2010 Final Research Report
  • [Presentation] T2マッピングによる関節軟骨の変性の評価 病理組織所見との対比2010

    • Author(s)
      岩間祐基、岩間祐基、後藤一, 他
    • Organizer
      第69回日本医学放射線学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超短TE(μTE)シークエンスを用いた関節軟骨の描出2010

    • Author(s)
      後藤一、藤井正彦、岩間祐基, 他
    • Organizer
      第69回日本医学放射線学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Magnetic resonance imaging of articular cartilage of the knee using ultrashort TE sequences with radial acquisition2010

    • Author(s)
      M.Fujii, Y.Iwama, H.Goto, N.Aoyama, H.Kawamitsu, M.Takizawa, Y.Ohno, K.Sugimura
    • Organizer
      22nd European Congress of Radiology
    • Place of Presentation
      Austria Center
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] MRI of articular cartilage of the knee with ultra short TE sequences.2010

    • Author(s)
      藤井正彦, 岩間祐基, 後藤一, et al
    • Organizer
      ECR (European Congress of Radiology)2010
    • Place of Presentation
      ウイーン
    • Related Report
      2010 Final Research Report
  • [Presentation] 超短TE(μTE)シークエンスを用いた関節軟骨の描出2009

    • Author(s)
      藤井正彦, 岩間祐基, 後藤一, 青山信和, 川光秀昭, 瀧澤将宏, 杉村和朗
    • Organizer
      第37回日本磁気共鳴医学会
    • Place of Presentation
      パンパシフィック横浜ベイホテル東急(神奈川県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 手関節における高分解能 kinematic MRI-健常ボランティアにおける検討-2009

    • Author(s)
      岩間祐基, 藤井正彦, 青山信和, 川光秀昭, 藤岡宏幸, 増田智徳, 小原陽子, 杉村和朗
    • Organizer
      第68回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3T-MRIにおける関節軟骨の描出能-病理組織像との対比を中心に-2008

    • Author(s)
      岩間祐基、藤井正彦, 青山信和, 川光秀昭, 黒田良祐, 杉村和朗
    • Organizer
      第67回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 3T-MRIの現状と展望-関節軟骨(再生)の3T-MRI-2008

    • Author(s)
      藤井正彦
    • Organizer
      第67回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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