Imaging of heart type fatty acid binding protein under acute reperfusion ischemia using radio-labeled antibody

• Project/Area Number: 20591463
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: MOMOSE Mitsuru Tokyo Women's Medical University, 医学部, 講師 (40312029)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: H-FABP / 抗体イメージング / I-125 / 急性冠症候群 / オートラジオグラフィー / 心筋脂肪酸結合蛋白 / I-125標識 / ラット心 / 虚血再灌流 / デジタルオートラジオグラム / I-123 BMIPP / Tc-99m MIBI

Research Abstract

Heart-type fatty acid binding protein (H-FABP) which is a primary transporter of free fatty acid, accumulated specifically in reperfused area under acute ischemia, and it accorded to the area where fatty acid metabolism was activated.

Research Products

• [Journal Article] Fatty acid metabolism is accelerated immediately after reperfusion ischemia in the isolated rat heart model (2011)
  • Author(s): Fukushima K, Momose M, Kondo C, Hagiwara N, Sakai S
  • Journal Title: Ann Nucl Med (in press)
  • Peer Reviewed
• [Journal Article] Myocardial kinetics of Tc-99m sestamibi in hypertensive heart failure using isolated rat heart model (2010)
  • Author(s): Fukushima K, Momose M, Kondo C, Kusakabe K, Hagiwara N
  • Journal Title: Nucl Med Biol 37(8) Pages: 1005-12
  • Peer Reviewed
• [Presentation] Imaging of 125I-anti H-FABP antibody in Acute Ischemia-Reperfusion Rat Heart (2009)
  • Author(s): 百瀬満
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-21
• [Presentation] Imaging of 125I-anti H-FABP antibody in acute ischemia-reperfusion rat heart (2009)
  • Author(s): 百瀬満,福島賢慈,金谷和子,日下部きよ子
  • Organizer: 第73回日本循環器学会総会学術集会
  • Year and Date: 2009-03-20
• [Presentation] ^<125>I-anti H-FABP Antibody Imaging in Acute Reperfusion Ischemia in Rat Heart (2008)
  • Author(s): Kenji Fukushima, Mitsuru Momose, Kazuko Kanaya, Chisato Kondo, Kiyoko Kusakabe, Nobuhisa Hagiwara
  • Organizer: American Heart Association Scientific Sessions, 2008
  • Place of Presentation: USA
  • Year and Date: 2008-11-12