Analysis of function of RhoGDIβ in the regulation of cell polarity and progression in colon cancer
| Project/Area Number |
20591596
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
OTA Takahide Kanazawa Medical University, 付置研究所, 准教授 (10152141)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大腸癌 / 悪性化 / RhoGDIβ / 中心体 / 有糸分裂 / 細胞極性 / DLD-1 / HeLa / がん転移 / centrosome / Mitosis / RhoGD1 |
|---|
| Research Abstract |
RhoGDIβ (Rho GDP-dissociation inhibitor β)is one of the regulators of Rho proteins that has been implicated in cancer progression; however, the specific role of RhoGDIβ in cells has been unclear. We examined its subcellular localization and the effects of RhoGDIβ knockdown by RNAi in cancer cells. Our results suggest that dysregulated expression of RhoGDIβ contributes to cancer progression through the regulation of centrosome function and cell polarity.
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Report
(4 results)
Research Products
(40 results)
