Implantation of fetal pig lung fragments into adult rat lung parenchyma-search for a possibility of transbronchial delivery with a bronchoscope-
| Project/Area Number |
20591672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKIYAMA Shoji The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60291986)
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| Co-Investigator(Kenkyū-buntansha) |
KENZAKI Koichirou 徳島大学, 病院, 講師 (70325265)
TAKIZAWA HIromitsu 徳島大学, 病院, 講師 (90332816)
TOBA Hiroaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40403745)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 呼吸器外科学 / 再生医療 / 移植 / 肺組織移植 / 胎生期肺 / 豚 / 経気道的投与 / 肺の発生分化 / 免疫抑制剤 / 肺組織 / 肺の発生 / 肺の分化 / 胎生期肺組織 / 胎仔肺移植 / 再生医学 |
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| Research Abstract |
Depending on our results of fetal lung tissue transplantation in the rat, fetal pig lung tissue which were dissected and cut into very fine pieces implanted into adult pig lung parenchyma. The implanted fetal lung tissues lived and matured in adult lungs. Under the situation of allograft combination, immunosuppression was needed to keep the implanted issues. Fetal lung tissues could be delivered into alveolar space using a bronchoscope, however, fetal lung tissues delivered by this method did not survived easier than by the method of transpleural implantation under thoracotomy.
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Report
(4 results)
Research Products
(7 results)
