Development of the Novel Dynamic Four-Dimensional CT Angiography to Predict the Rupture Risk in Cerebral Aneurysms.

• Project/Area Number: 20591684
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Mie University
• Principal Investigator: MATSUSHIMA Satoshi Mie University, 大学院・医学系研究科, 准教授 (50252367)
• Research Collaborator: ISHIDA Fujimaro 国立病院機構, 三重中央医療センター ; UMEDA Yasuyuki 三重大学, 医学部附属病院
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 脳血管障害学 / 脳動脈瘤 / CT脳血管造影 / 破裂リスク / 4次元CT / 壁運動 / 流体モデル

Research Abstract

We developed a novel dynamic 4-dimensional CT angiography to accurately evaluate dynamics in cerebral aneurysm. Movie artifacts disappeared on dynamic 4-dimensional CT angiography movies of 2 kinds of stationary phantoms (titanium clips and dry bone). In the virtual pulsating aneurysm model, pulsation on the dynamic 4-dimensional CT angiography movie resembled actual movement in terms of pulsation size. In a clinical study, dynamic 4-dimensional CT angiography showed 2-type motions : pulsation and anatomic positional changes of the cerebral artery. This newly developed 4-dimensional visualizing technique may deliver some clues to clarify the pathophysiology of cerebral aneurysms.

Research Products

• [Journal Article] Novel dynamic four-dimensional CT angiography revealing 2-type motions of cerebral arteries. (2011)
  • Author(s): Umeda Y, Ishida F, Hamada K, Fukazawa K, Miura Y, Toma N, Suzuki H, Matsushima S, Shimosaka S, Taki W
  • Journal Title: Stroke 42 Pages: 818-818
  • Peer Reviewed
• [Journal Article] Novel Dynamic Four-Dimensional CT Angiography Revealing 2-Type Motions of Cerebral Arteries. (2011)
  • Author(s): Umeda Y, Ishida F, Hamada K, Fukazawa K, Miura Y, Toma N, Suzuki H, Matsushima S, Shimosaka S, Taki W.
  • Journal Title: Stroke Volume: 42 Pages: 815-818
  • Peer Reviewed
• [Journal Article] 動眼神経麻痺で発症した内頚動脈後交通動脈分岐部動脈瘤における術中所見とCFD解析 (2010)
  • Author(s): 三浦洋一, 石田藤麿, 濱田和秀, 深澤恵児, 梅田靖之, 鈴木秀謙, 松島聡, 霜坂辰一, 滝和郎
  • Journal Title: 脳神経外科ジャーナル 19 Pages: 767-772
  • NAID: 110007730747
  • Peer Reviewed
• [Presentation] Dynamic Four-dimensional CT Angiography(DFA)を用いた拍動解析による新たな脳動脈瘤治療戦略 (2011)
  • Author(s): 石田藤麿, 梅田靖之, 深澤恵児, 古川和博, 鈴木秀謙, 松島聡, 霜坂辰一, 滝和郎
  • Organizer: 第40回日本神経放射線学会
  • Place of Presentation: 東京
• [Presentation] Dynamic Four-dimensional CT Angiography(DFA)を用いた脳動脈瘤の拍動解析の試み (2010)
  • Author(s): 石田藤麿, 梅田靖之, 深澤恵児, 古川和博, 鈴木秀謙, 松島聡, 霜坂辰一, 滝和郎
  • Organizer: 第69回日本脳神経外科学会学術総会
  • Place of Presentation: 福岡
• [Presentation] The computational flow dynamic study of middle cerebral artery aneurysms concerning the rupture risk. (2010)
  • Author(s): Umeda Y, Ishida F, Fukazawa K, Matsushima S, Shimosaka S, Taki W
  • Organizer: 7th International Intracranial Stent Meeting
  • Place of Presentation: Houston
• [Presentation] 新しい4D-CTA(DFA, Dynamic Four-dimensional CT Angiography)の臨床応用 (2010)
  • Author(s): 梅田靖之, 石田藤麿, 濱田和秀, 深澤恵児, 三浦洋一, 鈴木秀謙, 松原年生, 松島聡, 霜坂辰一, 滝和郎
  • Organizer: 第39回日本脳卒中の外科学会
  • Place of Presentation: 盛岡
• [Presentation] Dynamic Four-dimensional CT Angiography(DFA)の改良と臨床応用 (2010)
  • Author(s): 梅田靖之, 濱田和秀, 三浦洋一, 石田藤麿, 松島聡, 霜坂辰一, 滝和郎
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 東京
• [Presentation] Improvement of Dynamic Four-dimensional CT Angiography. (2009)
  • Author(s): 梅田靖之, 濱田和秀, 三浦洋一, 深澤恵児, 石田藤麿, 松島聡, 滝和郎
  • Organizer: 9th International Conference on Cerebrovascular Surgery
  • Place of Presentation: Nagoya
• [Presentation] Relationship between rupture point detected in intracranial aneurysm surgery and computational fluid dynamics study of ruptured cerebral aneurysms. (2009)
  • Author(s): Hamada K, Ishida F, Miura Y, Fukazawa K, Umeda Y, Matsushima S, Shimosaka S, Taki W
  • Organizer: 9th International Conference on Cerebrovascular Surgery
  • Place of Presentation: Nagoya
• [Presentation] Intraoperative findings and computational fluid dynamics of ruptured cerebral aneurysms. (2009)
  • Author(s): Ishida F, Miura Y, Hamada K, Fukazawa K, Umeda Y, Matsushima S, Shimosaka S, Taki W
  • Organizer: 6th International Intracranial Stent Meeting
  • Place of Presentation: Sendai
• [Presentation] Improvement of Dynamic Four-dimensional CT Angiography(DFA)and apply to the computational fluid dynamics. (2009)
  • Author(s): Umeda Y, Hamada K, Fukazawa K, Miura Y, Ishida F, Matsushima S, Shimosaka S, Taki W, Ota M
  • Organizer: 6th International Intracranial Stent Meeting
  • Place of Presentation: Sendai
• [Presentation] Dynamic Four-dimensional CT Angiography(DFA)の改良とCFDへの応用 (2009)
  • Author(s): 濱田和秀, 石田藤麿, 梅田靖之, 太田信, 三浦洋一, 松島聡, 霜坂辰一, 滝和郎
  • Organizer: 第38回日本脳卒中の外科学会
  • Place of Presentation: 松江
• [Presentation] Improvement of Dynamic Four-dimensional CT Angiography (DFA) and apply to the Computational Fluid Dynamics (2009)
  • Author(s): Y.Umeda, K.Hamada, K.Fukazawa, Y.Miura, F.Ishida, S.Matsushima, S.Shimosaka, W.Taki, N.Ota
  • Organizer: The 6th International Intracranial Stent Meeting
  • Place of Presentation: Sendai, Japan
• [Presentation] Improvement of Dynamic Four-dimensional CT Angiography (2009)
  • Author(s): Y.Umeda, K.Hamada, Y.Miura, K.Fukazawa, F.Ishida, S.Matsushima, W.Taki
  • Organizer: 9th Inernational Conference on Cerebrovascular Surgery
  • Place of Presentation: Nagoya, Japan
• [Presentation] Dynamic Four-dimensional CT Angiography (DFA)の改良とCFDへの応用 (2009)
  • Author(s): 濱田和秀
  • Organizer: 第38回日本脳卒中の外科学会
  • Place of Presentation: 島根県民会館・松江市