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Development of a novel multi-modal surgical navigation system with the integration of three-dimensional cerebrovascular imaging data.

Research Project

Project/Area Number 20591703
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionAkita University

Principal Investigator

MIZOI Kazuo  Akita University, 大学院・医学系研究科, 教授 (70157519)

Co-Investigator(Kenkyū-buntansha) SASAJIMA Toshio  秋田大学, 大学院・医学系研究科, 准教授 (40235289)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳神経外科 / 手術器機学 / 手術支援 / 手術支援システム / 手術機器学
Research Abstract

Thus far, in the field of neurosurgery, image-guided surgical navigation system has been used in limited field such as brain tumor surgery, stereotactic biopsy and stereotactic surgery. The aim of this study is to expand the use of the surgical navigation system to the field of cerebrovascular surgery. At first, we developed basic technology introducing three-dimensional cerebrovascular image data such as three-dimensional CT angiography (3D-CTA), three-dimensional rotational angiography (3D-RA) and three-dimensional ultrasonic angiography (3D-UA) into navigation system, and we measured the accuracy of registration three-dimensionally in phantom experiments and clinical setting. As a result, error in registration was 1-2mm, and this was considered to be sufficient accuracy to apply for the field of cerebrovascular surgery. In addition, we developed three-dimensional cerebrovascular image-guided surgical navigation system by which real-time update of registration became possible by integrating 3D-CTA, 3D-RA and 3D-UA, and evaluated the accuracy of registration. Error in registration in this navigation system was about 2 mm, and this was thought to be accuracy that clinical application is possible.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (28 results)

All 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (7 results) Book (6 results) Remarks (1 results)

  • [Journal Article] 頭蓋底髄膜腫に対するfractionated stereotactic radiotherapy (FSRT)による治療成績2010

    • Author(s)
      鈴木明、羽入紀朋、泉純一、佐久間郁郎、高橋和孝、柳澤俊晴、溝井和夫
    • Journal Title

      定位的放射線治療 14巻

      Pages: 26-31

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Skull base malignant lymphomaの1例-FDG-PET診断の重要性-2010

    • Author(s)
      島田直也、笹嶋寿郎、高橋和孝、高橋佑介、柴田憲一、柳澤俊晴、溝井和夫
    • Journal Title

      東北脳SPECT研究会講演集 19巻

      Pages: 9-13

    • Related Report
      2010 Final Research Report
  • [Journal Article] Association of stem cell marker CD133 expression with dissemination of glioblastomas.2010

    • Author(s)
      Sato A, Sasajima T, Beppu T, Ogawa A, Mizoi K, Tominaga T Kitanaka C, Kayama T
    • Journal Title

      Neurosurg Rev

      Volume: 33 Pages: 175-184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 頭蓋底髄膜腫に対するfractionated stereotactic radiotherapy(FSRT)による治療成績2010

    • Author(s)
      鈴木明, 羽入紀朋, 泉純一, 佐久間郁郎, 高橋和孝, 柳澤俊晴, 溝井和夫
    • Journal Title

      定位的放射線治療

      Volume: 14 Pages: 26-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skull base malignant lymphomaの1例-FDG・PET診断の重要性-2010

    • Author(s)
      島田直也, 笹嶋寿郎, 高橋和孝, 高橋佑介, 柴田憲一, 柳澤俊晴, 溝井和夫
    • Journal Title

      東北脳SPECT研究会講演集

      Volume: 19 Pages: 9-13

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 側脳室体部腫瘍の手術2009

    • Author(s)
      溝井和夫
    • Journal Title

      脳神経外科ジャーナル 18巻

      Pages: 187-195

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Limaprost alfadex improves myelopathy symptoms in patients with cervical spinal canal stenosis.2009

    • Author(s)
      Sugawara T, Hirano Y, Higashiyama N, Mizoi K
    • Journal Title

      Spine 34巻

      Pages: 551-555

    • NAID

      10027239605

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cylindrical cages.2009

    • Author(s)
      Sugawara T, Itoh Y, Hirano Y, Higashiyama N, Mizoi K
    • Journal Title

      Acta Neurochir 151巻

      Pages: 303-309

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 側脳室体部腫瘍の手術2009

    • Author(s)
      溝井和夫
    • Journal Title

      脳神経外科ジャーナル18 VOL.18

      Pages: 187-195

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limaprost alfadex improves myelopathy symptoms in patients with cervical spinal canal stenosis.2009

    • Author(s)
      Sugawara T, et al
    • Journal Title

      Spine VOL.34

      Pages: 551-555

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long term outcome and adjacent disc degeneration after anterior cervical disctomy and fusion with titanium cylindrical cages.2009

    • Author(s)
      Sugawara T, et al
    • Journal Title

      Acta.Neurochir. VOL.151

      Pages: 303-309

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axonal viability of corticospinal tracts evaluated by diffusion tensor imaging relates to reversible motor function and crossed cerebellar diaschisis.2008

    • Author(s)
      Kawashima A, Sasajima T, Shimosegawa E, Takahashi M, Suzuki A, Yasui N, Mizoi K
    • Journal Title

      Akita J Med 34巻

      Pages: 223-236

    • NAID

      110006968025

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Model Mice for Mild-Form Glycine Encephalopathy : Behavioral and Biochemical Characterizations and Efficacy of Antagonists for the Glycine Binding Site of N-Methyl D-Aspartate Receptor2008

    • Author(s)
      Kojima-Ishii K, et.al.
    • Journal Title

      Pediatric Research 64

      Pages: 228-233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative Pressure Pulmonary Edema Following Foramen Magnum Decompression for Chiari Malformation Type I-case report-2008

    • Author(s)
      Hirano Y, et.al.
    • Journal Title

      Neurologia medico-chirurgica 48

      Pages: 137-139

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳動脈瘤直達術における動注蛍光血管撮影の有用性-浅側頭動脈経由法2010

    • Author(s)
      柳澤俊晴、柴田憲一、島田直也、高橋和孝、笹嶋寿郎、溝井和夫
    • Organizer
      第69回日本脳神経外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 私の手術上達法-脳動脈瘤-2009

    • Author(s)
      溝井和夫
    • Organizer
      第18回脳神経外科手術と機器学会
    • Place of Presentation
      秋田
    • Year and Date
      2009-04-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 私の手術上達法-脳動脈瘤-2009

    • Author(s)
      溝井和夫
    • Organizer
      第18回脳神経外科手術と機器学会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 側脳室体部腫瘍への手術アプローチ2008

    • Author(s)
      溝井和夫
    • Organizer
      第28回日本脳神経外科コングレス
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-09
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 言語野近傍intrinsic tumorsに対する集学的治療戦略2008

    • Author(s)
      笹嶋寿郎、東山巨樹、高橋和孝、太田徹、鈴木明、茨木正信、木下俊文、溝井和夫
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 破裂脳動脈手術における術中DSAの安全性と有用性2008

    • Author(s)
      内藤雄一郎、柳澤俊晴、木内博之、笹嶋寿郎、太田徹、鈴木明、高橋和孝、東山巨樹,菅原卓、溝井和夫
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳磁図を用いた言語機能局在同定法の臨床応用2008

    • Author(s)
      太田徹、柴田憲一、東山巨樹、笹嶋寿郎、高橋和孝、柳澤俊晴、鈴木明、菅原卓、溝井和夫
    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Book] 脳神経検査のグノーティ・セアウトン(part1 MRI編、小川彰(編集))2010

    • Author(s)
      笹嶋寿郎、溝井和夫
    • Publisher
      シナジー、東京
    • Related Report
      2010 Final Research Report
  • [Book] 脳神経検査のグノーティ・セアウトンpart1 MRI編, 小川彰(編集)2010

    • Author(s)
      笹嶋寿郎, 溝井和夫
    • Publisher
      シナジー,東京
    • Related Report
      2010 Annual Research Report
  • [Book] 標準脳神経外科学(第11版)2008

    • Author(s)
      溝井和夫
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 側脳室髄膜腫(NS NOW3テント上髄膜腫-アプローチから摘出まで)2008

    • Author(s)
      溝井和夫
    • Publisher
      メジカルビュー社、東京
    • Related Report
      2010 Final Research Report
  • [Book] Oligodendroglial tumorsに対するmultimodal navigationを用いた外科治療(甲村英二(編))(脳腫瘍の外科-基本と挑戦-)2008

    • Author(s)
      笹嶋寿郎、東山巨樹、高橋和孝、太田徹、柴田憲一、茨木正信、木下俊文、溝井和夫
    • Publisher
      メディカ出版、大阪
    • Related Report
      2010 Final Research Report
  • [Book] 標準脳神経外科学第11版2008

    • Author(s)
      溝井和夫
    • Publisher
      医学書院
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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