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Is angiogenesis in regenerative medicine influenced by anesthetics and perioperative management methods?

Research Project

Project/Area Number 20591833
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionThe University of Tokushima

Principal Investigator

KAWAHITO Shinji  徳島大学, 病院, 講師 (60284296)

Co-Investigator(Kenkyū-buntansha) KITAHATA Hiroshi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60161486)
OSHITA Shuzo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords再生医療 / 血管新生 / 麻酔薬 / 周術期管理法 / 薬剤反応性
Research Abstract

We examined the influence of various anesthetics on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of the inhalation anesthetic should be less, and basic experiments using cultured cells indicated part of the intravenous anesthetic tended to promote angiogenesis. It is hoped that a new indicator of the perioperative administration is established by the influence of the anesthetic which gives it to angiogenesis being elucidated.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (30 results)

All 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (12 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Intensive insulin therapy during cardiovascular surgery2010

    • Author(s)
      Kawahito S, Kitahata H, Kitagawa T, Oshita S
    • Journal Title

      The Journal of Medical Investigation

      Volume: 57 Pages: 191-204

    • NAID

      130004465209

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児感染性心内膜炎の周術期管理における心エコーの役割2010

    • Author(s)
      川人伸次
    • Journal Title

      日本小児麻酔学会誌

      Volume: 16 Pages: 133-137

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous blood glucose monitoring and control for patients undergoing liver transplantation2010

    • Author(s)
      Shinji Kawahito I
    • Journal Title

      Anesthesiology

      Volume: 113(suppl)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Problems associated with glucose toxicity : role of hyperglycemiainduced oxidative stress.2009

    • Author(s)
      Kawahito S, Kitahata H, Oshita S
    • Journal Title

      World Journal of Gastroenterology

      Volume: 15 Pages: 4137-4142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Argon gas embolism in the application of laparoscopic microwave coagulation therapy2009

    • Author(s)
      Ikegami T, Shimada M, Imura S, Nakamura T, Kawahito S, Morine Y, Kanemura H, Hanaoka J
    • Journal Title

      Journal of Hepatobiliary Pancreatic Surgery

      Volume: 16 Pages: 394-398

    • NAID

      10025139457

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Problems associated with glucose toxicity : Role of hyperglycemia-induced oxidative stress2009

    • Author(s)
      Shinji Kawahito
    • Journal Title

      World Journal of Gastroenterology 15(33)

      Pages: 4137-4142

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of continuous blood glucose monitoring during cardiovascular surgery2009

    • Author(s)
      Shinji Kawahito
    • Journal Title

      Anesthesiology 108(suppl)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of the β1-blocker landiolol with early and late sevoflurane-induced preconditioning2009

    • Author(s)
      Hiroshi Kitahata
    • Journal Title

      Anesthesiology 108(suppl)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone2008

    • Author(s)
      Kitahata H, Nozaki J, Kawahito S, Tomino T, Oshita S
    • Journal Title

      Anesthesia and Analgesia

      Volume: 107 Pages: 755-761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two unusual complications associated with cardiopulmonary bypass for pediatric cardiac surgery detected by transesophageal echocardiography after decannulation2008

    • Author(s)
      Nitta K, Kawahito S, Kitahata H, Nozaki J, Katayama T, Oshita S
    • Journal Title

      Pediatric Anesthesia

      Volume: 18 Pages: 325-329

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implications of intraoperative transesophageal ventricular pacing in pediatric patients2008

    • Author(s)
      Yamanaka A, Kitahata H, Tanaka K, Kawahito S, Oshita S
    • Journal Title

      Journal of Cardiothoracic and Vascular Anesthesia

      Volume: 22 Pages: 92-94

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous intraoperative blood glucose monitoring and control using the STG-22 closed-loop system2008

    • Author(s)
      Shinji Kawahito
    • Journal Title

      Anesthesiology 109(suppl)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose sevoflurane inhalation enhances late cardioprotection the anti-ulcer drug geranylgeranylacetone2008

    • Author(s)
      Hiroshi Kitahata
    • Journal Title

      Anesth Analg 107(3)

      Pages: 755-761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Continuous blood glucose monitoring and control for patients undergoing liver transplantation2010

    • Author(s)
      Kawahito S, Kitahata H, Okada T, Hirose K, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 冠動脈疾患(OPCAB)とTEE2010

    • Author(s)
      川人伸次
    • Organizer
      第15回日本心臓血管麻酔学会
    • Place of Presentation
      東京都(ザ・プリンスパークタワー東京)
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児両心室ペースメーカ移植術の術中管理における経食道心エコーの役割2010

    • Author(s)
      川人伸次
    • Organizer
      日本小児麻酔学会第16回大会
    • Place of Presentation
      倉敷市(芸文館)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児心臓外科手術における強化インスリン療法の確立-体外循環中の連続血糖モニタリング・コントロールー2010

    • Author(s)
      川人伸次
    • Organizer
      第37回日本集中治療医学会学術集会
    • Place of Presentation
      広島市
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 人工膵臓の術中使用における利点と欠点2010

    • Author(s)
      川人伸次
    • Organizer
      第27回日本集中治療医学会中国四国地方会
    • Place of Presentation
      高知市
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Usefulness of continuous blood glucose monitoring during cardiovascular surgery2009

    • Author(s)
      Kawahito S, Kitahata H, Nakamura T, Okada T, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2009-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Interaction of theβ1-blocker landiolol with early and late sevoflurane-induced preconditioning2009

    • Author(s)
      Kitahata H, Nozaki J, Kawahito S, Tomiyama Y, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Insulin therapy during and after cardiopulmonary bypass2009

    • Author(s)
      Kawahito S, Kitahata H
    • Organizer
      The 8th Meeting of the Asian Society of Cardiothoracic Anesthesia
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2009-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Landiolol produces cardioprotection in patients undergoing off-pump coronary artery bypass surgery2008

    • Author(s)
      Wakamatsu N, Kawahito S, Kitahata H, Goh R, Kohyama A
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2008-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Continuous intraoperative blood glucose monitoring and control using the STG-22 closed-loop system2008

    • Author(s)
      Kawahito S, Kitahata H, Nakamura T, Iseki A, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2008-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Continuous intraoperative blood glucose monitoring and control using the STG-22 closed-loop system2008

    • Author(s)
      Shinji Kawahito
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intensive insulin therapy in patients undergoing living-related liver transplantation2008

    • Author(s)
      Nakamura T, Kawahito S, Kitahata H, Tomiyama Y, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2008-10-18
    • Related Report
      2010 Final Research Report
  • [Book] 第II章循環器心筋梗塞の既往がある2010

    • Author(s)
      北畑洋, 川人伸次
    • Publisher
      分光堂,東京
    • Related Report
      2010 Final Research Report
  • [Book] 第III部生理学と病理学,第12章塞栓症2010

    • Author(s)
      岡田剛、川人伸次
    • Publisher
      メディカル・サイエンス・インターナショナル,東京
    • Related Report
      2010 Final Research Report
  • [Book] 社団法人日本麻酔科学会出版,東京2009

    • Author(s)
      川人伸次
    • Publisher
      モルヒネ塩酸塩水和物,モルヒネ硫酸塩水和物
    • Related Report
      2010 Final Research Report
  • [Book] 感染性心内膜炎の非心臓手術2008

    • Author(s)
      川人伸次
    • Publisher
      総合医学社,東京
    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.tokushima-u.ac.jp/med/culture/masui_totsu/ikyoku/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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