| Project/Area Number |
20591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
MURAKAWA Masahiro Fukushima Medical University, 医学部, 病院長 (90182112)
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| Research Collaborator |
NEMOTO Chiaki 福島県立医科大学, 医学部, 助教 (30443865)
HAKOZAKI Takahiro 福島県立医科大学, 医学部, 大学院生 (60595429)
AOKI Ken-ichi 福島県立医科大学, 医学部, 大学院研究生
HIRAMA Takahiro 福島県立医科大学, 医学部, 大学院研究生
KANNO Ryoko 福島県立医科大学, 医学部, 主任医療技師
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 術後せん妄 / 吸入麻酔薬 / 鎮静薬 / 手術ストレス / アセチルコリン / 脳内微小透析法 / 脳内マイクロダイアリースス / 疼痛 / セボフルラン / エンフルラン / ハロタン / マイクロダイアリーシス / イソフルラン / ACTH / プロポフォール / ミダゾラム / デクスメデトミジン |
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| Research Abstract |
To clarify the neurochemical basis for postoperative delirium, the changes of acetylcholine release in rat cerebral cortex by the painful stimulation during general anesthesia and by the sedation were studied using brain microdialysis. The acetylcholine release was significantly affected by widely-used inhalational anesthetics and sedatives. The results of this study suggest that the occurrence of post-operative delirium is related to the changes in cholinergic neuronal activities in the brain.
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