Elucidation of the intracellular mechanisms concerning monocyte tissue factor production and release, and their applications of the gene therapy
| Project/Area Number |
20591842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NAKAJIMA Yasufumi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (70326239)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Hiroshi 京都府立医科大学, 医学研究科, 助教 (20381965)
MIZOBE Toshiki 京都府立医科大学, 医学研究科, 講師 (50239266)
HASHIMOTO Satoru 京都府立医科大学, 医学研究科, 准教授 (90167578)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | RNA干渉法 / 遺伝子治療 / 静脈性血栓塞栓症 / 周術期 |
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| Research Abstract |
We have demonstrated the modification of tissue factor expression on THP-1 cell and mouse monocyte-macrophage by knocking down ERK1, ERk-1 and Egr-1. With injection of these gene knocked down monocytes into mouse, survival rate and severity of pulmonary embolism have improved in mouse experimental model. Further studies are necessary to undergo several analysis, and their application of the gene therapy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Phosphodiesterase 3 inhibition reduces platelet activation and monocyte tissue factor expression in knee arthroplasty patients.2009
Author(s)
Beppu, S., Nakajima, Y, Shibasaki, M., Kageyama, K., Mizobe, T., Shime, N., Matsuda, N.
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Journal Title
Anesthesiology 111
Pages: 1227-1237
Related Report
Peer Reviewed
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