| Project/Area Number |
20591846
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Hyogo College of Medicine |
|---|
Principal Investigator |
TATARA Tsuneo Hyogo College of Medicine, 医学部, 教授 (30207039)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KARIYA Nobutaka 兵庫医科大学, 医学部, 准教授 (20305642)
UEKI Ryusuke 兵庫医科大学, 医学部, 講師 (10340986)
TASHIRO Chikara 兵庫医科大学, 医学部, 病院長 (20107048)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 周術期管理学 / 代用血漿製剤 / 透過性 / ヒドロキシエチルデンプン / 分子量 / テイドロキシエチルスターチ / 代用血漿剤 / 膠質浸透圧 / ハイドロキシエチルスターチ / 半透膜 |
|---|
| Research Abstract |
Tissue edema during surgery delays recovery after surgery. This study investigated whether low-molecular weight (MW) hydroxyethyl starch (HES) solution reduces tissue edema during surgery. Low-MW HES significantly inhibited solute diffusion from polyacrylamide gel compared to high-MW HES. However, degree of tissue edema in patients undergoing open abdominal surgery was comparable for low-MW and high-MW HES, suggesting no apparent effect of reduction of tissue edema for low-MW HES.
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