Function determination and exploiting biomarker kit of brain-type free fatty acid binding protein in tumor microenvironment
| Project/Area Number |
20591854
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
OZONO Seiichiro Hamamatsu University School of Medicine, 医学部, 教授 (00183228)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Tatsuya 浜松医科大学, 医学部附属病院, 講師 (90324350)
TERATANI Takumi 自治医科大学, 医学部, 助教 (70373404)
TAKAOKA Naohisa 浜松医科大学, 医学部, 特任研究員 (30467229)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 腫瘍学 / 腎癌 / 脳型遊離脂肪酸結合蛋白 / S100蛋白 / 低酸素バイオロジー / バイオマーカー |
|---|
| Research Abstract |
We identified brain-type fatty acid binding protein(B-FABP) as a specific biomarker. First of all, we have made up anti-B-FABP antibody, we also determined the expression of B-FABP in the urine. Promoter analysis revealed that Brn-2, NF1 and YY1 affect on the expression of B-FABP. Function determination of B-FABP by metabolome analysis in tumor microenvironment should be lead to the development of tumor biology.
|
Report
(4 results)
Research Products
(130 results)
-
-
-
-
[Journal Article] Japanese Society of Renal Cancer. Late Recurrence of Renal Cell Carcinoma : Retrospective and Collaborative Study of the Japanese Society of Renal Cancer.2011
Author(s)
Miyao N, Naito S, Ozono S, Shinohara N, Masumori N, Igarashi T, Nakao M, Tsushima T, Senga Y, Horie S, Kanayama HO, Tokuda N, Kobayashi M
-
Journal Title
Urology Vol.77
Pages: 379-384
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Reduction of transforming growth factor- type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.2010
Author(s)
Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Suzuki S, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Hayashi H, Ozono S, Kitagawa M, Hishida A.
-
Journal Title
URL
Related Report
-
[Journal Article] Prognosis of Japanese Metastatic Renal Cell Carcinoma Patients in the Cytokine Era : A Cooperative Group Report of 1463 Patients.2010
Author(s)
Naito S, Yamamoto N, Takayama T, Muramoto M, Shinohara N, Nishiyama K, Takahashi A, Maruyama R, Saika T, Hoshi S, Nagao K, Yamamoto S, Sugimura I, Uemura H, Koga S, Takahashi M, Ito F, Ozono S, Terachi T, Naito S, Tomita Y.
-
Journal Title
Eur Urol Vol.57
Pages: 317-326
Related Report
Peer Reviewed
-
-
-
[Journal Article] A phase II study of sunitinib in Japanese patients with metastatic renal cell carcinoma : insights into the treatment、efficacy and safety.2010
Author(s)
Uemura H, Shinohara N, Yuasa T, Tomita Y, Fujimoto H, Niwakawa M, Mugiya S, Miki T, Nonomura N, Takahashi M, Hasegawa Y, Agata N, Houk B, Naito S, Akaza H.
-
Journal Title
Jpn J Clin Oncol Vol.40
Pages: 194-202
Related Report
-
-
-
-
[Journal Article] Successful Outcomes Using Combination Therapy of Interleukin-2 and Interferon-{alpha} for Renal Cell Carcinoma Patients with Lung Metastasis.2010
Author(s)
Akaza H, Kawai K, Tsukamoto T, Fujioka T, Tomita Y, Kitamura T, Ozono S, Miki T, Naito S, Zembutsu H, Nakamura Y
-
Journal Title
Jpn J Clin Oncol Vol.40
Pages: 684-689
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Overall Survival and Updated Results from a Phase II Study of Sunitinib in Japanese Patients with Metastatic Renal Cell Carcinoma.2010
Author(s)
Tomita Y, Shinohara N, Yuasa T, Fujimoto H, Niwakawa M, Mugiya S, Miki T, Uemura H, Nonomura N, Takahashi M, Hasegawa Y, Agata N, Houk B, Naito S, Akaza H.
-
Journal Title
URL
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Impact of thymidine phosphorylase-expressing macrophages for surgical margin in partial nephrectomy.2009
Author(s)
Liu H, Takayama T, Ogawa H, Kai F, Sugiyama T, Aoki T, Harada M, Otsuka A, Furuse H, Kurita Y, Mugiya S, Ushiyama T, Ozono S.
-
Journal Title
Urol Int Vol.82
Pages: 388-393
Related Report
Peer Reviewed
-
[Journal Article] 腎細胞癌2009
Author(s)
大園誠一郎
-
Journal Title
104th American Urological Association Annual Meeting Highlights of AUA
Pages: 37-38
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Predicting response to IL-2 and IFN-α combination therapy for renal cell carcinoma through genome-wide gene expression profiling.2010
Author(s)
Mizumori O, Zembutsu H, Kato Y, Tsukamoto T, Fujioka T, Tomita Y, Kitamura T, Ozono S, Miki T, Naito S, Akaza H, Nakamura Y.
Organizer
AACR/JCA Joint Conference : Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
Place of Presentation
Waikoloa, Hawaii.
Year and Date
2010-02-06
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Analysis of lipid profile of renal cell carcinoma by imaging mass spectrometry.2009
Author(s)
Takayama T, Zaima N, Kyono Y, Miyazaki M, Takaoka T, Nagata M, Kai F, Sugiyama T, Setou M, Ozono S.
Organizer
欧州癌・癌治療学会(Joint ECCO 15-34th ESMO)
Place of Presentation
Berlin, Germany.
Year and Date
2009-09-21
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 腎細胞癌周囲に浸潤したマクロファージが産生するthymidine phosphoylase活性はT1aN0M0腎癌の腎部分切除ライン決定の根拠となり得る2008
Author(s)
高山達也,劉紅明,高岡直央,甲斐文丈,杉山貴之,青木高広,細川真吾,今西武志,原田雅樹,古瀬洋,麦谷荘一,牛山知己,大園誠一郎
Organizer
第96回日本泌尿器科学会総会
Place of Presentation
横浜市
Year and Date
2008-04-27
Related Report
-
-
-
-
-
-
-
